E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Research (Original Article) 


Experimental Studies on Some Zoonotic Diarrheagenic Agents in Albino Rats

Mohamed A. Nossair, Mousa A. Ayoub, Reham S. El-Maadawy, Sabah I. Shaaban.

Abstract
Since various pathogens or factors have been implicated in the development of diarrheic disease, laboratory testing is necessary for accurate diagnosis. The current study was designed to obtain an idea about the pathological effect of Salmonella, E.coli and Cryptosporidium on GIT in rat model. A total of 48 early mature, male albino rats (Swiss Webster) were used to study the course of the infection with E.coli O18, S. Enteritidis and Cryptosporidium during a 30-day period, with special emphasis on clinical signs, bacterial dissemination, oocyst shedding and finally histopathologic changes in target organs. The results revealed that E. coli 018 had pathogenic potential in rats. Shedding of E. coli organisms in faeces detected from 2nd day post infection (PI) by conventional culture methods. While, using quantitative real time PCR (qPCR) it was detected for longer periods. In Salmonella infected group, shedding o f S. Enteritidis was detected only in 2nd day PI by conventional methods while by using qPCR was detected for longer periods. Cryptosporidium oocyst shedding in immunocompetent rats began on the day 4 PI and reached the peak on day 11 PI. The intensities of oocyst shedding were significantly greater in the immunosuppressed rats than in the non-immunosuppressed ones. The results of this study confirmed the use of rat model in the experimental infections to evaluate the negative impacts of diarrheic agents on human health is of great value and it is required to understand the pathogenesis of these infectious agents as these models help us to make simulation for human host. They also help to evaluate the diagnostic procedures that would help in development of control programs.

Key words: Salmonella, E. coli, Cryptosporidium, Experimental, Studies, Rats,


 
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Pubmed Style

Mohamed A. Nossair| Mousa A. Ayoub| Reham S. El-Maadawy| Sabah I. Shaaban. Experimental Studies on Some Zoonotic Diarrheagenic Agents in Albino Rats. AJVS. 2018; 58(1): 196-207. doi:10.5455/ajvs.1176


Web Style

Mohamed A. Nossair| Mousa A. Ayoub| Reham S. El-Maadawy| Sabah I. Shaaban. Experimental Studies on Some Zoonotic Diarrheagenic Agents in Albino Rats. http://www.alexjvs.com/?mno=1176 [Access: October 15, 2018]. doi:10.5455/ajvs.1176


AMA (American Medical Association) Style

Mohamed A. Nossair| Mousa A. Ayoub| Reham S. El-Maadawy| Sabah I. Shaaban. Experimental Studies on Some Zoonotic Diarrheagenic Agents in Albino Rats. AJVS. 2018; 58(1): 196-207. doi:10.5455/ajvs.1176



Vancouver/ICMJE Style

Mohamed A. Nossair| Mousa A. Ayoub| Reham S. El-Maadawy| Sabah I. Shaaban. Experimental Studies on Some Zoonotic Diarrheagenic Agents in Albino Rats. AJVS. (2018), [cited October 15, 2018]; 58(1): 196-207. doi:10.5455/ajvs.1176



Harvard Style

Mohamed A. Nossair| Mousa A. Ayoub| Reham S. El-Maadawy| Sabah I. Shaaban (2018) Experimental Studies on Some Zoonotic Diarrheagenic Agents in Albino Rats. AJVS, 58 (1), 196-207. doi:10.5455/ajvs.1176



Turabian Style

Mohamed A. Nossair| Mousa A. Ayoub| Reham S. El-Maadawy| Sabah I. Shaaban. 2018. Experimental Studies on Some Zoonotic Diarrheagenic Agents in Albino Rats. Alexandria Journal of Veterinary Sciences, 58 (1), 196-207. doi:10.5455/ajvs.1176



Chicago Style

Mohamed A. Nossair| Mousa A. Ayoub| Reham S. El-Maadawy| Sabah I. Shaaban. "Experimental Studies on Some Zoonotic Diarrheagenic Agents in Albino Rats." Alexandria Journal of Veterinary Sciences 58 (2018), 196-207. doi:10.5455/ajvs.1176



MLA (The Modern Language Association) Style

Mohamed A. Nossair| Mousa A. Ayoub| Reham S. El-Maadawy| Sabah I. Shaaban. "Experimental Studies on Some Zoonotic Diarrheagenic Agents in Albino Rats." Alexandria Journal of Veterinary Sciences 58.1 (2018), 196-207. Print. doi:10.5455/ajvs.1176



APA (American Psychological Association) Style

Mohamed A. Nossair| Mousa A. Ayoub| Reham S. El-Maadawy| Sabah I. Shaaban (2018) Experimental Studies on Some Zoonotic Diarrheagenic Agents in Albino Rats. Alexandria Journal of Veterinary Sciences, 58 (1), 196-207. doi:10.5455/ajvs.1176





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