E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Research (Original Article) 


Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits

Heba-allah M. Saad, Mostafa M. Hassieb, Samah S. Oda, Hossam G. Tohamy, Asmaa F. Khafaga.

Abstract
The present study was designed to investigate the adverse effects of aluminum chloride hexahydrate on the heart, liver and kidneys of rabbits. Twenty-four apparently healthy male and female rabbits were randomly assigned to four groups. The two control groups male (n= 6) and female (n= 6) received subcutaneous injections of physiological saline. The other two Al-treated groups of male (n= 6) and female (n= 6) were given 2.5mg/kg B.W. S/C five times per week for 3 months. At the 6th weeks and the 12th weeks, three rabbits from each group were necropsied and tissues specimens from heart, liver and kidneys were collected and processed for the following histopathologic examination. The heart of both sexes of intoxicated rabbits showed congestion of blood vessels, interfibrillar edema, hemorrhage as well as Zenker's degeneration and necrosis of myocardium. The Liver showed periportal edema, mild fibroplasia, infiltration of inflammatory cells, adenomatous and papillary hyperplasia of bile ductules. The encountered lesions of the kidneys were in the form of vacuolations and necrosis of renal tubular epithelium, with intratubular necrotic cellular debris and hyaline casts. An additional lesion of severe interstitial nephritis was also seen in some areas. It was concluded that the adverse toxic effects of aluminum chloride were time-dependent manner on heart, kidneys and liver of of both sexes of rabbits.

Key words: aluminum chloride, rabbits, heart, liver, kidneys, Zenker's degeneration.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Heba-allah M. Saad
Articles by Mostafa M. Hassieb
Articles by Samah S. Oda
Articles by Hossam G. Tohamy
Articles by Asmaa F. Khafaga
on Google
on Google Scholar
Article Statistics
 Viewed: 470
Downloaded: 139
Cited: 0

How to Cite this Article
Pubmed Style

Saad HM, Hassieb MM, Oda SS, Tohamy HG, Khafaga AF. Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. AJVS. 2018; 56(1): 102-109. doi:10.5455/ajvs.264783


Web Style

Saad HM, Hassieb MM, Oda SS, Tohamy HG, Khafaga AF. Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. http://www.alexjvs.com/?mno=264783 [Access: June 24, 2018]. doi:10.5455/ajvs.264783


AMA (American Medical Association) Style

Saad HM, Hassieb MM, Oda SS, Tohamy HG, Khafaga AF. Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. AJVS. 2018; 56(1): 102-109. doi:10.5455/ajvs.264783



Vancouver/ICMJE Style

Saad HM, Hassieb MM, Oda SS, Tohamy HG, Khafaga AF. Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. AJVS. (2018), [cited June 24, 2018]; 56(1): 102-109. doi:10.5455/ajvs.264783



Harvard Style

Saad, H. M., Hassieb, M. M., Oda, S. S., Tohamy, H. G. & Khafaga, A. F. (2018) Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. AJVS, 56 (1), 102-109. doi:10.5455/ajvs.264783



Turabian Style

Saad, Heba-allah M., Mostafa M. Hassieb, Samah S. Oda, Hossam G. Tohamy, and Asmaa F. Khafaga. 2018. Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. Alexandria Journal of Veterinary Sciences, 56 (1), 102-109. doi:10.5455/ajvs.264783



Chicago Style

Saad, Heba-allah M., Mostafa M. Hassieb, Samah S. Oda, Hossam G. Tohamy, and Asmaa F. Khafaga. "Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits." Alexandria Journal of Veterinary Sciences 56 (2018), 102-109. doi:10.5455/ajvs.264783



MLA (The Modern Language Association) Style

Saad, Heba-allah M., Mostafa M. Hassieb, Samah S. Oda, Hossam G. Tohamy, and Asmaa F. Khafaga. "Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits." Alexandria Journal of Veterinary Sciences 56.1 (2018), 102-109. Print. doi:10.5455/ajvs.264783



APA (American Psychological Association) Style

Saad, H. M., Hassieb, M. M., Oda, S. S., Tohamy, H. G. & Khafaga, A. F. (2018) Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. Alexandria Journal of Veterinary Sciences, 56 (1), 102-109. doi:10.5455/ajvs.264783





Most Viewed Articles
  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract & References

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract & References » doi: 10.5455/ajvs.48333

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract & References » doi: 10.5455/ajvs.154650

  • Surgical and Histological Evaluation of the Effectiveness of Propolis on Wound Healing
    Ramadan El Sayed Abd Elwahed, Mahmoud Hussein El Kammar, Islam Reda Edrees
    AJVS. 2013; 39(1): 52-63
    » Abstract & References

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract & References » doi: 10.5455/ajvs.45443

  • Evaluation of a Rapid Immunochromatographic Test for Detection of Brucella Abortus Antibodies in Egyptian Cattle Sera and Milk
    Tharwat M. Elshemey, Amir H. Abd-Elrahman
    AJVS. 2014; 40(1): 24-28
    » Abstract & References » doi: 10.5455/ajvs.47307

  • Effect of Lead Toxicity on Mineral Metabolism and Immunological Factors in Rats
    Nabil M Taha, Mahdy S. Korshom, abd El-Wahab M Mandour, Mohamed A Lebdah, Eman S aladham
    AJVS. 2013; 39(1): 64-73
    » Abstract & References

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract & References » doi: 10.5455/ajvs.48232

  • Antigenic Variations of Infectious Bronchitis Virus from Broiler flocks in Al Behera Governorate
    Sarah E. AlBeltagi, Helmy A. Torky, Mahmoud E. Seddeek
    AJVS. 2014; 40(1): 44-51
    » Abstract & References » doi: 10.5455/ajvs.46652

  • Improving Production Traits for El-salam and Mandarah Chicken Strains by Crossing I- Estimation of Crossbreeding Effects for Growth Production Traits
    Ayman El-Sayed Taha, Fawzy Ali Abd El-Ghany
    AJVS. 2013; 39(1): 18-30
    » Abstract & References

  • Most Downloaded
  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract & References » doi: 10.5455/ajvs.48333

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract & References » doi: 10.5455/ajvs.45443

  • Evaluation of a Rapid Immunochromatographic Test for Detection of Brucella Abortus Antibodies in Egyptian Cattle Sera and Milk
    Tharwat M. Elshemey, Amir H. Abd-Elrahman
    AJVS. 2014; 40(1): 24-28
    » Abstract & References » doi: 10.5455/ajvs.47307

  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract & References

  • Antigenic Variations of Infectious Bronchitis Virus from Broiler flocks in Al Behera Governorate
    Sarah E. AlBeltagi, Helmy A. Torky, Mahmoud E. Seddeek
    AJVS. 2014; 40(1): 44-51
    » Abstract & References » doi: 10.5455/ajvs.46652

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract & References » doi: 10.5455/ajvs.48232

  • Effect of Lead Toxicity on Mineral Metabolism and Immunological Factors in Rats
    Nabil M Taha, Mahdy S. Korshom, abd El-Wahab M Mandour, Mohamed A Lebdah, Eman S aladham
    AJVS. 2013; 39(1): 64-73
    » Abstract & References

  • Aerobic Bacteria Associated with Omphalitis of Chicks [English]
    Khalil, S. A. and Einas, El-Shamy
    AJVS. 2012; 37(1): 69-77
    » Abstract

  • Surgical and Histological Evaluation of the Effectiveness of Propolis on Wound Healing
    Ramadan El Sayed Abd Elwahed, Mahmoud Hussein El Kammar, Islam Reda Edrees
    AJVS. 2013; 39(1): 52-63
    » Abstract & References

  • Using Double Dose of GnRH for Reducing Incidence of Cystic Ovaries in Cows
    Wael MB Noseir, Kamal K Metwally, Negm N Shaker
    AJVS. 2013; 39(1): 124-132
    » Abstract & References » doi: 10.5455/ajvs.40648

  • Most Cited Articles
  • Antifibrotic Effect of Curcumin on Thioacetamide Induced Liver Fibrosis
    Suzan E. Abdou, Nabil M. Taha, Abd El-Wahab A. Mandour, Mohamed A. Lebda, Hanaa R. El Hofi, Amany MSE El-Morshedy
    AJVS. 2015; 45(1): 43-50
    » Abstract & References » doi: 10.5455/ajvs.179458
    Cited : 4 times [Click to see citing articles]

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract & References » doi: 10.5455/ajvs.48333
    Cited : 3 times [Click to see citing articles]

  • Adverse Effects of Ivermectin in comparison with Rafoxanide on Male Rats
    Abd El-Salam F. El-Sawy, Zeynab Kh. El-Maddawy and Soaad A. Seed
    AJVS. 2015; 47(1): 119-128
    » Abstract & References » doi: 10.5455/ajvs.198997
    Cited : 3 times [Click to see citing articles]

  • Enumeration and Characterization of Aeromonas spp. Isolated from Milk and Some Dairy Products in Sharkia Governorate, Egypt
    Nagwa I. ElBalat, Salah F. Abd-ElAal, Madeha A. Ayoub, Magdy S. Elsayed
    AJVS. 2014; 40(1): 52-64
    » Abstract & References » doi: 10.5455/ajvs.49073
    Cited : 2 times [Click to see citing articles]

  • Comparison of Lidocaine and Lidocaine–Neostigmine for Epidural Analgesia in Water Buffalo Calves (Bubalus Bubalis)
    Alaa Ghazy, Ayman Atiba, Mustafa Shukry, Tarek Kamal
    AJVS. 2015; 46(1): 177-181
    » Abstract & References » doi: 10.5455/ajvs.198171
    Cited : 2 times [Click to see citing articles]

  • The Growth Promoting Effect of Beta-glucan in Comparison with Sodium Butyrate in Broiler Chicks
    Abd El-Salam F. El-Sawy, Zeynab Kh. El-Maddawy, Hawary S. Ibrahiem and El-Sadeq Bo-Ghazel
    AJVS. 2015; 44(1): 23-37
    » Abstract & References » doi: 10.5455/ajvs.163992
    Cited : 2 times [Click to see citing articles]

  • Association of Hsp70 Gene Polymorphism And Bull Semen Quality In Winter And Summer Seasons
    Jehan A. Gafer, Ghada H. Abd El-Rahman, Rawash Z. M.
    AJVS. 2015; 46(1): 1-14
    » Abstract & References » doi: 10.5455/ajvs.186038
    Cited : 2 times [Click to see citing articles]

  • Enterobacteriaceae In Beef Products (Luncheon, Pasterma, Frankfurter and Minced meat) from Alexandria Retail Outlets
    Noha M. El-Gendy, Hossam A. Ibrahim, Nahla A. Al-Shabasy, and Ibrahim A. Samaha
    AJVS. 2014; 41(1): 80-86
    » Abstract & References » doi: 10.5455/ajvs.151171
    Cited : 2 times [Click to see citing articles]

  • Detection of Molecular Characterization of Salmonella enterica isolated from Chicken Meat and Its Products by Using Multiplex PCR
    Heba S. Amin and Abd El-Rahman A. Abd El-Rahman
    AJVS. 2015; 46(1): 155-160
    » Abstract & References » doi: 10.5455/ajvs.196302
    Cited : 2 times [Click to see citing articles]

  • Assessment of Freezability and Functional Integrity of Dromedary Camel Spermatozoa Harvested from Caput, Corpus and Cauda Epididymides
    El-Badry, D.A., Scholkamy, T.H., Abeer M. Anwer and Karima Gh.M. Mahmoud
    AJVS. 2015; 44(1): 147-158
    » Abstract & References » doi: 10.5455/ajvs.178345
    Cited : 2 times [Click to see citing articles]