E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Research (Original Article) 


Impact of L-Carnitine on Bisphenol A-Induced Kidney Damage in Rats

Hanan A. Edres, Nabil M. Taha, Abd El-Wahab A. Mandour, Mohamed A. Lebda.

Abstract
The present study aimed to explore the protective effects of L-carnitine on the oxidative stress induced by Bisphenol A (BPA) in rat kidneys. Forty male adult rats were allocated into four groups (10 rats each); placebo, BPA (50 mg/kg bwt per os), L-carnitine (500 mg/kg bwt i.p), and the BPA/L-carnitine-treated group. After 70 days, blood and kidneys were collected for measurement of renal function, oxidative/antioxidative status, histopathological analyses, and gene expression of nrf2. BPA significantly increased serum urea and carnitine levels suggesting renal damage evidenced by hydropic degenerative changes and hydronephrosis. The level of malondialdehyde (MDA) in kidney was elevated along with decline in renal total antioxidant capacity (TAC) and reduced glutathione (GSH) concentrations following challenged with BPA. Notably, the expression of nrf2 mRNA transcript in kidney tissues was down-regulated after BPA-induced toxicity. L-carnitine treatment ameliorates the damaged effects of BPA on kidneys as indicated by low levels of serum urea and carnitine, and renal MDA. Further, L-carnitine enhances the antioxidants (TAC, and GSH), with up-regulation of nrf2 expression in kidney tissues. Our results suggest the renoprotective activity of L-carnitine in BPA-induced kidney injuries through induction of antioxidant system and modulation of oxidative stress

Key words: Bisphenol A, L-carnitine, Malondialdehyde, Hydronephrosis, Glutathione


 
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How to Cite this Article
Pubmed Style

Edres HA, Taha NM, Mandour AEA, Lebda MA. Impact of L-Carnitine on Bisphenol A-Induced Kidney Damage in Rats. AJVS. 2018; 56(1): 11-17. doi:10.5455/ajvs.283744


Web Style

Edres HA, Taha NM, Mandour AEA, Lebda MA. Impact of L-Carnitine on Bisphenol A-Induced Kidney Damage in Rats. http://www.alexjvs.com/?mno=283744 [Access: September 19, 2018]. doi:10.5455/ajvs.283744


AMA (American Medical Association) Style

Edres HA, Taha NM, Mandour AEA, Lebda MA. Impact of L-Carnitine on Bisphenol A-Induced Kidney Damage in Rats. AJVS. 2018; 56(1): 11-17. doi:10.5455/ajvs.283744



Vancouver/ICMJE Style

Edres HA, Taha NM, Mandour AEA, Lebda MA. Impact of L-Carnitine on Bisphenol A-Induced Kidney Damage in Rats. AJVS. (2018), [cited September 19, 2018]; 56(1): 11-17. doi:10.5455/ajvs.283744



Harvard Style

Edres, H. A., Taha, N. M., Mandour, A. E. A. & Lebda, M. A. (2018) Impact of L-Carnitine on Bisphenol A-Induced Kidney Damage in Rats. AJVS, 56 (1), 11-17. doi:10.5455/ajvs.283744



Turabian Style

Edres, Hanan A., Nabil M. Taha, Abd El-Wahab A. Mandour, and Mohamed A. Lebda. 2018. Impact of L-Carnitine on Bisphenol A-Induced Kidney Damage in Rats. Alexandria Journal of Veterinary Sciences, 56 (1), 11-17. doi:10.5455/ajvs.283744



Chicago Style

Edres, Hanan A., Nabil M. Taha, Abd El-Wahab A. Mandour, and Mohamed A. Lebda. "Impact of L-Carnitine on Bisphenol A-Induced Kidney Damage in Rats." Alexandria Journal of Veterinary Sciences 56 (2018), 11-17. doi:10.5455/ajvs.283744



MLA (The Modern Language Association) Style

Edres, Hanan A., Nabil M. Taha, Abd El-Wahab A. Mandour, and Mohamed A. Lebda. "Impact of L-Carnitine on Bisphenol A-Induced Kidney Damage in Rats." Alexandria Journal of Veterinary Sciences 56.1 (2018), 11-17. Print. doi:10.5455/ajvs.283744



APA (American Psychological Association) Style

Edres, H. A., Taha, N. M., Mandour, A. E. A. & Lebda, M. A. (2018) Impact of L-Carnitine on Bisphenol A-Induced Kidney Damage in Rats. Alexandria Journal of Veterinary Sciences, 56 (1), 11-17. doi:10.5455/ajvs.283744





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