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Original Research (Original Article) 


Reproductive Effects of Clanobutin Sodium or Menbutone Diethanolamine

Abd El-Salam F. El-Sawy, Zeynab Kh. El-Maddawy, Hawary S. Ibrahiem.

Abstract
The present study was conducted to evaluate the effect of clanobutin sodium and menbutone diethanolamine each alone on some male fertility parameters of male goats. Moreover, the possible adverse effects of repeated administration of these drugs on the foeti of pregnant female rats and/ or induction of abortion were evaluated. Therefore, two experiments were carried out; the first was done on 15 apparently healthy mature un-castrated male goats of Zaraibi breed (1.5-2 year old) were divided into 3 equal groups. The 1st group: goats received basal ration and water without any treatment, the 2nd group: goats administered with clanobutin sodium (20 mg/kg b.wt in the 1st day and 10 mg/kg b.wt. in the 2nd day weekly for 8 weeks) and the 3rd group: goats administered with menbutone diethanolamine (10 mg/kg b.wt in the 1st day and 5 mg/kg b.wt. in the 2nd day weekly for 8 weeks). The second experiment was done on 45 pregnant female rats were divided into 3 equal groups. The 1st group of rats received basal ration and water, the 2nd group: rats administered with clanobutin sodium (40 mg/kg b.wt from 5th to 15th day of pregnancy period) and the 3rd group: rats administered with menbutone diethanolamine (20 mg/kg b.wt from 5th to 15th day of pregnancy period). The obtained results showed that administration of these drugs showed a deteriorating effect on male and female fertility parameters. Both drugs induced significant decrease in sperm concentration, sperm progressive motility, normal sperm %, in comparison with the control group of male goats all over the periods of the experiment. Also, the drugs induced a significant reduction in serum testosterone with significant increase on serum FSH and LH levels with harmful histophthological alterations in testis and epididymis Moreover, in the second experiment number, weights of foeti and number of live foeti on both uterine horns of pregnant female rats was significantly decreased with increased number of dead foeti on both clanobutin sodium and menbutone diethanolamine treated groups of rats in comparison with the control group.
These results concluded that the use of both drugs on male or female animals intended for breeding must be avoided.

Key words: clanobutin sodium, menbutone diethanolamine, semen characters , testis, epididymis, pregnant female.


 
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Pubmed Style

El-Sawy AEF, El-Maddawy ZK, Ibrahiem HS. Reproductive Effects of Clanobutin Sodium or Menbutone Diethanolamine. AJVS. 2018; 59(1): 107-118. doi:10.5455/ajvs.302507


Web Style

El-Sawy AEF, El-Maddawy ZK, Ibrahiem HS. Reproductive Effects of Clanobutin Sodium or Menbutone Diethanolamine. http://www.alexjvs.com/?mno=302507 [Access: November 17, 2018]. doi:10.5455/ajvs.302507


AMA (American Medical Association) Style

El-Sawy AEF, El-Maddawy ZK, Ibrahiem HS. Reproductive Effects of Clanobutin Sodium or Menbutone Diethanolamine. AJVS. 2018; 59(1): 107-118. doi:10.5455/ajvs.302507



Vancouver/ICMJE Style

El-Sawy AEF, El-Maddawy ZK, Ibrahiem HS. Reproductive Effects of Clanobutin Sodium or Menbutone Diethanolamine. AJVS. (2018), [cited November 17, 2018]; 59(1): 107-118. doi:10.5455/ajvs.302507



Harvard Style

El-Sawy, A. E. F., El-Maddawy, . Z. K. & Ibrahiem, . H. S. (2018) Reproductive Effects of Clanobutin Sodium or Menbutone Diethanolamine. AJVS, 59 (1), 107-118. doi:10.5455/ajvs.302507



Turabian Style

El-Sawy, Abd El-Salam F., Zeynab Kh. El-Maddawy, and Hawary S. Ibrahiem. 2018. Reproductive Effects of Clanobutin Sodium or Menbutone Diethanolamine. Alexandria Journal of Veterinary Sciences, 59 (1), 107-118. doi:10.5455/ajvs.302507



Chicago Style

El-Sawy, Abd El-Salam F., Zeynab Kh. El-Maddawy, and Hawary S. Ibrahiem. "Reproductive Effects of Clanobutin Sodium or Menbutone Diethanolamine." Alexandria Journal of Veterinary Sciences 59 (2018), 107-118. doi:10.5455/ajvs.302507



MLA (The Modern Language Association) Style

El-Sawy, Abd El-Salam F., Zeynab Kh. El-Maddawy, and Hawary S. Ibrahiem. "Reproductive Effects of Clanobutin Sodium or Menbutone Diethanolamine." Alexandria Journal of Veterinary Sciences 59.1 (2018), 107-118. Print. doi:10.5455/ajvs.302507



APA (American Psychological Association) Style

El-Sawy, A. E. F., El-Maddawy, . Z. K. & Ibrahiem, . H. S. (2018) Reproductive Effects of Clanobutin Sodium or Menbutone Diethanolamine. Alexandria Journal of Veterinary Sciences, 59 (1), 107-118. doi:10.5455/ajvs.302507





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