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Original Research (Original Article) 


Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin

Hosny Abd Elfadil, Ahmed A. Mohamed, Amany Behairy, Heba M. Abdel-Ghany, Eman M. Amaym.

Abstract
Levofloxacin is considered a strong weapon against several bacterial infections but its serious side effects limit its use. Curcumin, glucosamine hydrochloride (Gls) and vitamin C (Vit C) have strong effective properties. Hence, the study was carried out to assess their protective roles on levofloxacin adverse effects in immature albino rats. Fifty immature male albino rats were divided into five equal groups: I- Control group (received sterile saline solution) orally; II- Levofloxacin group (10mg/kg b.wt) intraperitoneally; III- Levofloxacin + curcumin (200mg/kg b.wt) orally; IV- Levofloxacin + Gls (500mg/kg b.wt) orally; V- Levofloxacin + Vit C (100mg/kg b.wt) intraperitoneally. Rats were euthanized on zero day and 14 days post treatment. The degree of protection was measured using calcium (Ca), phosphorus (P), alkaline phosphatase (ALP) and oxidative biomarkers levels. Furthermore, specimens from tendon, joint, ligament and cartilage were collected and subjected to routine histological technique. Levofloxacin significantly decreased Ca concentration and increased P level and ALP activity. Co-administration of curcumin, Gls and/or Vit C restored these biochemical alterations and improved antioxidant defense system. Levofloxacin produced degeneration of collagen fibers of tendons, necrosis of chondrocytes and destruction to lacunae of articular cartilage of joint, degeneration of collagen bundles of ligaments. Curcumin, Gls and/or Vit C were also markedly ameliorated histopathological effect of levofloxacin. In conclusion, curcumin, Gls and/or Vit C exerted protective actions against levofloxacin adverse effects.

Key words: Levofloxacin, Immature rats, Curcumin, Glucosamine hydrochloride, Vitamin C


 
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Pubmed Style

Elfadil HA, Mohamed AA, Behairy A, Abdel-Ghany HM, Amaym EM. Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin. AJVS. 2019; 62(1): 182-193. doi:10.5455/ajvs.51618


Web Style

Elfadil HA, Mohamed AA, Behairy A, Abdel-Ghany HM, Amaym EM. Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin. http://www.alexjvs.com/?mno=51618 [Access: December 14, 2019]. doi:10.5455/ajvs.51618


AMA (American Medical Association) Style

Elfadil HA, Mohamed AA, Behairy A, Abdel-Ghany HM, Amaym EM. Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin. AJVS. 2019; 62(1): 182-193. doi:10.5455/ajvs.51618



Vancouver/ICMJE Style

Elfadil HA, Mohamed AA, Behairy A, Abdel-Ghany HM, Amaym EM. Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin. AJVS. (2019), [cited December 14, 2019]; 62(1): 182-193. doi:10.5455/ajvs.51618



Harvard Style

Elfadil, H. A., Mohamed, . A. A., Behairy, . A., Abdel-Ghany, . H. M. & Amaym, . E. M. (2019) Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin. AJVS, 62 (1), 182-193. doi:10.5455/ajvs.51618



Turabian Style

Elfadil, Hosny Abd, Ahmed A. Mohamed, Amany Behairy, Heba M. Abdel-Ghany, and Eman M. Amaym. 2019. Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin. Alexandria Journal of Veterinary Sciences, 62 (1), 182-193. doi:10.5455/ajvs.51618



Chicago Style

Elfadil, Hosny Abd, Ahmed A. Mohamed, Amany Behairy, Heba M. Abdel-Ghany, and Eman M. Amaym. "Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin." Alexandria Journal of Veterinary Sciences 62 (2019), 182-193. doi:10.5455/ajvs.51618



MLA (The Modern Language Association) Style

Elfadil, Hosny Abd, Ahmed A. Mohamed, Amany Behairy, Heba M. Abdel-Ghany, and Eman M. Amaym. "Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin." Alexandria Journal of Veterinary Sciences 62.1 (2019), 182-193. Print. doi:10.5455/ajvs.51618



APA (American Psychological Association) Style

Elfadil, H. A., Mohamed, . A. A., Behairy, . A., Abdel-Ghany, . H. M. & Amaym, . E. M. (2019) Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin. Alexandria Journal of Veterinary Sciences, 62 (1), 182-193. doi:10.5455/ajvs.51618





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