E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Research (Original Article) 


Bergenin Ameliorates Glutamate-Induced Death of Hippocampal Neuronal Cells through Modulation of the Antioxidant Activity and reducing the redox oxygen Species Creation

Mustafa Shukry, Ahmed Hafez, Emad W. Ghazy, Foad Farrag, Mohamed M.A. Abumandour.

Abstract
Oxytosis is a disproportion between the manufacturing and manifestation of reactive oxygen species and the ability of a biological system to restore the resulting injury. In mouse hippocampal cells, HT22, the neuroprotective impact of Bergenin against glutamate-induced oxidative stress was explored. The findings showed that bergenin protected cells against toxicity caused by glutamate at 10 μM and improved their impact in a dose-dependent way until peak protection at 30 μM was achieved. Pretreatment with bergenin, which was clarified using a Cell viability assay (WST-1Assay), considerably suppressed the elevation of glutamate-induced reactive oxygen species and consequently secure HT22 cells against death from glutamate. And this protection reduced by glutamate through restoration of glutathione concentrations. Besides upregulating glutathione activity, the antioxidant ability to scavenge ROS also activates PPARπ, which controls various pro-inflammatory cytokines.

Key words: Bergenin; HT22;Antioxidant activity; ROS; PPARπ agonist


 
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Pubmed Style

Shukry M, Hafez A, Ghazy EW, Farrag F, Abumandour MM. Bergenin Ameliorates Glutamate-Induced Death of Hippocampal Neuronal Cells through Modulation of the Antioxidant Activity and reducing the redox oxygen Species Creation. AJVS. 2019; 62(1): 79-88. doi:10.5455/ajvs.55719


Web Style

Shukry M, Hafez A, Ghazy EW, Farrag F, Abumandour MM. Bergenin Ameliorates Glutamate-Induced Death of Hippocampal Neuronal Cells through Modulation of the Antioxidant Activity and reducing the redox oxygen Species Creation. http://www.alexjvs.com/?mno=55719 [Access: December 14, 2019]. doi:10.5455/ajvs.55719


AMA (American Medical Association) Style

Shukry M, Hafez A, Ghazy EW, Farrag F, Abumandour MM. Bergenin Ameliorates Glutamate-Induced Death of Hippocampal Neuronal Cells through Modulation of the Antioxidant Activity and reducing the redox oxygen Species Creation. AJVS. 2019; 62(1): 79-88. doi:10.5455/ajvs.55719



Vancouver/ICMJE Style

Shukry M, Hafez A, Ghazy EW, Farrag F, Abumandour MM. Bergenin Ameliorates Glutamate-Induced Death of Hippocampal Neuronal Cells through Modulation of the Antioxidant Activity and reducing the redox oxygen Species Creation. AJVS. (2019), [cited December 14, 2019]; 62(1): 79-88. doi:10.5455/ajvs.55719



Harvard Style

Shukry, M., Hafez, . A., Ghazy, . E. W., Farrag, . F. & Abumandour, . M. M. (2019) Bergenin Ameliorates Glutamate-Induced Death of Hippocampal Neuronal Cells through Modulation of the Antioxidant Activity and reducing the redox oxygen Species Creation. AJVS, 62 (1), 79-88. doi:10.5455/ajvs.55719



Turabian Style

Shukry, Mustafa, Ahmed Hafez, Emad W. Ghazy, Foad Farrag, and Mohamed M.A. Abumandour. 2019. Bergenin Ameliorates Glutamate-Induced Death of Hippocampal Neuronal Cells through Modulation of the Antioxidant Activity and reducing the redox oxygen Species Creation. Alexandria Journal of Veterinary Sciences, 62 (1), 79-88. doi:10.5455/ajvs.55719



Chicago Style

Shukry, Mustafa, Ahmed Hafez, Emad W. Ghazy, Foad Farrag, and Mohamed M.A. Abumandour. "Bergenin Ameliorates Glutamate-Induced Death of Hippocampal Neuronal Cells through Modulation of the Antioxidant Activity and reducing the redox oxygen Species Creation." Alexandria Journal of Veterinary Sciences 62 (2019), 79-88. doi:10.5455/ajvs.55719



MLA (The Modern Language Association) Style

Shukry, Mustafa, Ahmed Hafez, Emad W. Ghazy, Foad Farrag, and Mohamed M.A. Abumandour. "Bergenin Ameliorates Glutamate-Induced Death of Hippocampal Neuronal Cells through Modulation of the Antioxidant Activity and reducing the redox oxygen Species Creation." Alexandria Journal of Veterinary Sciences 62.1 (2019), 79-88. Print. doi:10.5455/ajvs.55719



APA (American Psychological Association) Style

Shukry, M., Hafez, . A., Ghazy, . E. W., Farrag, . F. & Abumandour, . M. M. (2019) Bergenin Ameliorates Glutamate-Induced Death of Hippocampal Neuronal Cells through Modulation of the Antioxidant Activity and reducing the redox oxygen Species Creation. Alexandria Journal of Veterinary Sciences, 62 (1), 79-88. doi:10.5455/ajvs.55719





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