E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Research (Original Article) 


Role of Silymarin in Restoring the Deleterious Effects induced by Dexamethasone in Male Rats

Abd El-Salam F. El- Sawy, Zeynab Kh. El-Maddawy, Neveen R. Ashoura.

Abstract
Abstract:
The present study was conducted to evaluate the protective effect of Silymarin on deleterious effects of dexamethasone on hepatic and renal functions tests, hematological parameters and histopathological changes of some organs in male rats. Twenty four mature male rats were used and divided equally into 4 groups .The first group was daily administered with distilled water (2ml/kg. b.wt) orally by stomach tube and saline (2ml/kg. b.wt) i/m twice weekly with 72 hrs interval .The second group was daily administered with silymarin ( 50mg/kg b.wt.), given orally by stomach tube. The third group was treated with dexamethasone sodium phosphate (0.25mg/kg. b.wt) intramuscularly twice weekly with 72 hrs interval .The fourth group was treated with dexamethasone sodium phosphate by the same dose concomitantly with daily administration of silymarin .The treatment was done for one month .The obtained results showed that i.m. injection of dexamethasone induced a significant (P≤ 0.05) increase in serum levels of alanine amino transfers (ALT), alkaline phosphatase (ALP) ,triglycerides , malondaldahyde (MDA), urea and creatinine .While, it induced a significant (P≤ 0.05) decrease in serum total protein , globulin values, total cholesterol, total antioxidant capacity ,Red blood corpuscles count (RBCs ), white blood cell count (WBCs), packed cell volume (PCV%) , also, it induced eosinopenia ,lymphocytopenia and neutrophilia .Moreover, dexamethasone induced histopathological changes on liver , kidney , spleen and lymph node . While, administration of silymarin concomitantly with dexamethasone induced marked improvement in all previous biochemical and hematogical parameters induced by dexamethasone in male albino rats. It could be concluded that dexamethasone induced hazard effects on blood picture, hepatic and renal function testes .While, silymarin could be successed to ameliorate these effects in male albino rats.

Key words: Keywords: hepato- renal function , dexamethasone , Silymarin ,antioxidant


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Abd El-Salam F. El- Sawy
Articles by Zeynab Kh. El-Maddawy
Articles by Neveen R. Ashoura
on Google
on Google Scholar
Article Statistics
 Viewed: 269
Downloaded:
Cited: 0

How to Cite this Article
Pubmed Style

Sawy AEFE, El-Maddawy ZK, Ashoura NR. Role of Silymarin in Restoring the Deleterious Effects induced by Dexamethasone in Male Rats. AJVS. 2018; 59(2): 125-135. doi:10.5455/ajvs.5950


Web Style

Sawy AEFE, El-Maddawy ZK, Ashoura NR. Role of Silymarin in Restoring the Deleterious Effects induced by Dexamethasone in Male Rats. http://www.alexjvs.com/?mno=5950 [Access: January 24, 2019]. doi:10.5455/ajvs.5950


AMA (American Medical Association) Style

Sawy AEFE, El-Maddawy ZK, Ashoura NR. Role of Silymarin in Restoring the Deleterious Effects induced by Dexamethasone in Male Rats. AJVS. 2018; 59(2): 125-135. doi:10.5455/ajvs.5950



Vancouver/ICMJE Style

Sawy AEFE, El-Maddawy ZK, Ashoura NR. Role of Silymarin in Restoring the Deleterious Effects induced by Dexamethasone in Male Rats. AJVS. (2018), [cited January 24, 2019]; 59(2): 125-135. doi:10.5455/ajvs.5950



Harvard Style

Sawy, A. E. F. E., El-Maddawy, . Z. K. & Ashoura, . N. R. (2018) Role of Silymarin in Restoring the Deleterious Effects induced by Dexamethasone in Male Rats. AJVS, 59 (2), 125-135. doi:10.5455/ajvs.5950



Turabian Style

Sawy, Abd El-Salam F. El-, Zeynab Kh. El-Maddawy, and Neveen R. Ashoura. 2018. Role of Silymarin in Restoring the Deleterious Effects induced by Dexamethasone in Male Rats. Alexandria Journal of Veterinary Sciences, 59 (2), 125-135. doi:10.5455/ajvs.5950



Chicago Style

Sawy, Abd El-Salam F. El-, Zeynab Kh. El-Maddawy, and Neveen R. Ashoura. "Role of Silymarin in Restoring the Deleterious Effects induced by Dexamethasone in Male Rats." Alexandria Journal of Veterinary Sciences 59 (2018), 125-135. doi:10.5455/ajvs.5950



MLA (The Modern Language Association) Style

Sawy, Abd El-Salam F. El-, Zeynab Kh. El-Maddawy, and Neveen R. Ashoura. "Role of Silymarin in Restoring the Deleterious Effects induced by Dexamethasone in Male Rats." Alexandria Journal of Veterinary Sciences 59.2 (2018), 125-135. Print. doi:10.5455/ajvs.5950



APA (American Psychological Association) Style

Sawy, A. E. F. E., El-Maddawy, . Z. K. & Ashoura, . N. R. (2018) Role of Silymarin in Restoring the Deleterious Effects induced by Dexamethasone in Male Rats. Alexandria Journal of Veterinary Sciences, 59 (2), 125-135. doi:10.5455/ajvs.5950





Most Viewed Articles
  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract & References

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract & References » doi: 10.5455/ajvs.48333

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract & References » doi: 10.5455/ajvs.154650

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract & References » doi: 10.5455/ajvs.45443

  • Surgical and Histological Evaluation of the Effectiveness of Propolis on Wound Healing
    Ramadan El Sayed Abd Elwahed, Mahmoud Hussein El Kammar, Islam Reda Edrees
    AJVS. 2013; 39(1): 52-63
    » Abstract & References

  • Evaluation of a Rapid Immunochromatographic Test for Detection of Brucella Abortus Antibodies in Egyptian Cattle Sera and Milk
    Tharwat M. Elshemey, Amir H. Abd-Elrahman
    AJVS. 2014; 40(1): 24-28
    » Abstract & References » doi: 10.5455/ajvs.47307

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract & References » doi: 10.5455/ajvs.48232

  • Effect of Lead Toxicity on Mineral Metabolism and Immunological Factors in Rats
    Nabil M Taha, Mahdy S. Korshom, abd El-Wahab M Mandour, Mohamed A Lebdah, Eman S aladham
    AJVS. 2013; 39(1): 64-73
    » Abstract & References

  • Antigenic Variations of Infectious Bronchitis Virus from Broiler flocks in Al Behera Governorate
    Sarah E. AlBeltagi, Helmy A. Torky, Mahmoud E. Seddeek
    AJVS. 2014; 40(1): 44-51
    » Abstract & References » doi: 10.5455/ajvs.46652

  • Improving Production Traits for El-salam and Mandarah Chicken Strains by Crossing I- Estimation of Crossbreeding Effects for Growth Production Traits
    Ayman El-Sayed Taha, Fawzy Ali Abd El-Ghany
    AJVS. 2013; 39(1): 18-30
    » Abstract & References

  • Most Downloaded
  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract & References » doi: 10.5455/ajvs.48333

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract & References » doi: 10.5455/ajvs.48232

  • Using of Polypropylene Mesh for Hernioplasty in Calves
    Mostafa M. kassam, Mahmoud H. Elkammer, Ahmed S. Korittum, Ali A. Abdel-Wahed
    AJVS. 2014; 40(1): 112-117
    » Abstract & References » doi: 10.5455/ajvs.47290

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract & References » doi: 10.5455/ajvs.45443

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract & References » doi: 10.5455/ajvs.154650

  • Evaluation of a Rapid Immunochromatographic Test for Detection of Brucella Abortus Antibodies in Egyptian Cattle Sera and Milk
    Tharwat M. Elshemey, Amir H. Abd-Elrahman
    AJVS. 2014; 40(1): 24-28
    » Abstract & References » doi: 10.5455/ajvs.47307

  • Antigenic Variations of Infectious Bronchitis Virus from Broiler flocks in Al Behera Governorate
    Sarah E. AlBeltagi, Helmy A. Torky, Mahmoud E. Seddeek
    AJVS. 2014; 40(1): 44-51
    » Abstract & References » doi: 10.5455/ajvs.46652

  • Effect of Lead Toxicity on Mineral Metabolism and Immunological Factors in Rats
    Nabil M Taha, Mahdy S. Korshom, abd El-Wahab M Mandour, Mohamed A Lebdah, Eman S aladham
    AJVS. 2013; 39(1): 64-73
    » Abstract & References

  • Aerobic Bacteria Associated with Omphalitis of Chicks [English]
    Khalil, S. A. and Einas, El-Shamy
    AJVS. 2012; 37(1): 69-77
    » Abstract

  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract & References

  • Most Cited Articles
  • Antifibrotic Effect of Curcumin on Thioacetamide Induced Liver Fibrosis
    Suzan E. Abdou, Nabil M. Taha, Abd El-Wahab A. Mandour, Mohamed A. Lebda, Hanaa R. El Hofi, Amany MSE El-Morshedy
    AJVS. 2015; 45(1): 43-50
    » Abstract & References » doi: 10.5455/ajvs.179458
    Cited : 4 times [Click to see citing articles]

  • Adverse Effects of Ivermectin in comparison with Rafoxanide on Male Rats
    Abd El-Salam F. El-Sawy, Zeynab Kh. El-Maddawy and Soaad A. Seed
    AJVS. 2015; 47(1): 119-128
    » Abstract & References » doi: 10.5455/ajvs.198997
    Cited : 4 times [Click to see citing articles]

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract & References » doi: 10.5455/ajvs.48333
    Cited : 3 times [Click to see citing articles]

  • Detection of Molecular Characterization of Salmonella enterica isolated from Chicken Meat and Its Products by Using Multiplex PCR
    Heba S. Amin and Abd El-Rahman A. Abd El-Rahman
    AJVS. 2015; 46(1): 155-160
    » Abstract & References » doi: 10.5455/ajvs.196302
    Cited : 3 times [Click to see citing articles]

  • The Growth Promoting Effect of Beta-glucan in Comparison with Sodium Butyrate in Broiler Chicks
    Abd El-Salam F. El-Sawy, Zeynab Kh. El-Maddawy, Hawary S. Ibrahiem and El-Sadeq Bo-Ghazel
    AJVS. 2015; 44(1): 23-37
    » Abstract & References » doi: 10.5455/ajvs.163992
    Cited : 3 times [Click to see citing articles]

  • Evaluation of a Rapid Immunochromatographic Test for Detection of Brucella Abortus Antibodies in Egyptian Cattle Sera and Milk
    Tharwat M. Elshemey, Amir H. Abd-Elrahman
    AJVS. 2014; 40(1): 24-28
    » Abstract & References » doi: 10.5455/ajvs.47307
    Cited : 2 times [Click to see citing articles]

  • Enumeration and Characterization of Aeromonas spp. Isolated from Milk and Some Dairy Products in Sharkia Governorate, Egypt
    Nagwa I. ElBalat, Salah F. Abd-ElAal, Madeha A. Ayoub, Magdy S. Elsayed
    AJVS. 2014; 40(1): 52-64
    » Abstract & References » doi: 10.5455/ajvs.49073
    Cited : 2 times [Click to see citing articles]

  • Comparison of Lidocaine and Lidocaine–Neostigmine for Epidural Analgesia in Water Buffalo Calves (Bubalus Bubalis)
    Alaa Ghazy, Ayman Atiba, Mustafa Shukry, Tarek Kamal
    AJVS. 2015; 46(1): 177-181
    » Abstract & References » doi: 10.5455/ajvs.198171
    Cited : 2 times [Click to see citing articles]

  • Effect of Vitrification by Straw and Cryotop on DNA Integrity Using Comet Assay with Reference To Brilliant Cresyl Blue Exposure in Buffalo Oocytes
    Scholkamy T.H., Samah F. Darwish, karima M. Mahmoud
    AJVS. 2015; 46(1): 117-123
    » Abstract & References » doi: 10.5455/ajvs.187719
    Cited : 2 times [Click to see citing articles]

  • Association of Hsp70 Gene Polymorphism And Bull Semen Quality In Winter And Summer Seasons
    Jehan A. Gafer, Ghada H. Abd El-Rahman, Rawash Z. M.
    AJVS. 2015; 46(1): 1-14
    » Abstract & References » doi: 10.5455/ajvs.186038
    Cited : 2 times [Click to see citing articles]