E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats

Hayam O. Mosolin, El-Sayed E. Mehana, Samah S. Oda, Samar S. Elblehi, Dina R. Gad El-Karim.

Abstract
This study was carried out to evaluate the presumptive ameliorative effect of Green tea (GT) and Quercetin (Q) against Cadmium (Cd) induced hepato-renal toxicity in rats. Sixty male albino rats were randomly divided into 6 groups (n=10); control group: orally received distilled water, Cd-treated group: orally received CdCl2 (5 mg/kg b.wt./day, 3 times /week), GT-treated group: orally received GT extract (200 mg/kg b.wt./day 3 times / week), Q-treated group: orally received Q (50 mg/kg b.wt./day 3 times / week), Cd+GT and Cd+Q -treated groups received a combination of cadmium, green tea extract or quercetin at the same previous doses and routes. All the experimental procedures were continued for eight weeks. Intoxication with cadmium revealed a significant elevation in serum liver enzymes, total and direct bilirubin with a significant decrease in serum levels of total proteins and albumin. Also, there was a significant elevation in serum urea and creatinine levels. In addition to, the Cd exhibited severe oxidative stress that represented by a significant increase in renal and hepatic malondialdhyde (MDA) and a significant decrease in reduced glutathione (GSH) and catalase (CAT). Histopathologically, Cd revealed severe degenerative and necrotic lesions in the livers and kidneys. The mixed treatment with GT and Q- attenuated Cd-induced oxidative stress, serum biochemical alterations related to hepato-renal damge and histopathological changes in liver and kidney. However, the co-treatment with Q showed better protection than GT against Cd induced toxicity in rats.
Keywords: Cadmium, green tea, quercetin, rats, hepato-renal toxicity.

Key words: s: Cadmium, green tea, quercetin, rats, hepato-renal toxicity.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Hayam O. Mosolin
Articles by El-Sayed E. Mehana
Articles by Samah S. Oda
Articles by Samar S. Elblehi
Articles by Dina R. Gad El-Karim
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Mosolin HO, Mehana EE, Oda SS, Elblehi SS, El-Karim DRG. Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats. AJVS. 2022; 73(1): 101-110. doi:10.5455/ajvs.11657


Web Style

Mosolin HO, Mehana EE, Oda SS, Elblehi SS, El-Karim DRG. Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats. https://www.alexjvs.com/?mno=11657 [Access: December 06, 2023]. doi:10.5455/ajvs.11657


AMA (American Medical Association) Style

Mosolin HO, Mehana EE, Oda SS, Elblehi SS, El-Karim DRG. Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats. AJVS. 2022; 73(1): 101-110. doi:10.5455/ajvs.11657



Vancouver/ICMJE Style

Mosolin HO, Mehana EE, Oda SS, Elblehi SS, El-Karim DRG. Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats. AJVS. (2022), [cited December 06, 2023]; 73(1): 101-110. doi:10.5455/ajvs.11657



Harvard Style

Mosolin, H. O., Mehana, . E. E., Oda, . S. S., Elblehi, . S. S. & El-Karim, . D. R. G. (2022) Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats. AJVS, 73 (1), 101-110. doi:10.5455/ajvs.11657



Turabian Style

Mosolin, Hayam O., El-Sayed E. Mehana, Samah S. Oda, Samar S. Elblehi, and Dina R. Gad El-Karim. 2022. Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats. Alexandria Journal of Veterinary Sciences, 73 (1), 101-110. doi:10.5455/ajvs.11657



Chicago Style

Mosolin, Hayam O., El-Sayed E. Mehana, Samah S. Oda, Samar S. Elblehi, and Dina R. Gad El-Karim. "Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats." Alexandria Journal of Veterinary Sciences 73 (2022), 101-110. doi:10.5455/ajvs.11657



MLA (The Modern Language Association) Style

Mosolin, Hayam O., El-Sayed E. Mehana, Samah S. Oda, Samar S. Elblehi, and Dina R. Gad El-Karim. "Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats." Alexandria Journal of Veterinary Sciences 73.1 (2022), 101-110. Print. doi:10.5455/ajvs.11657



APA (American Psychological Association) Style

Mosolin, H. O., Mehana, . E. E., Oda, . S. S., Elblehi, . S. S. & El-Karim, . D. R. G. (2022) Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats. Alexandria Journal of Veterinary Sciences, 73 (1), 101-110. doi:10.5455/ajvs.11657





Most Viewed Articles
Most Accessed Articles

  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract » doi: 10.5455/ajvs.154650

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract » doi: 10.5455/ajvs.45443

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

  • Most Downloaded
    Top Downloaded Articles

  • Comparative Study of Cellular and Humoral Immune Response to BHV-1 Vaccines in Cattle and Buffalo Calves
    Fayrouz S. Naim; Samy A. Khalil and Helmy A. Torky
    AJVS. 2016; 51(2): 367-373
    » Abstract

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

  • Effect of Excess Fluoride on Reproductive Potentials in Farm Animals (Ovine)
    Ghada H. Abdel-Rahman, Hanaa A. El-Hallawany, Dohreig RA.
    AJVS. 2018; 57(2): 41-57
    » Abstract » doi: 10.5455/ajvs.296364

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Using of Polypropylene Mesh for Hernioplasty in Calves
    Mostafa M. kassam, Mahmoud H. Elkammer, Ahmed S. Korittum, Ali A. Abdel-Wahed
    AJVS. 2014; 40(1): 112-117
    » Abstract » doi: 10.5455/ajvs.47290

  • Most Cited Articles
    Most Cited Articles