E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


Pharmacodynamics Studies on Ricobendazole In Male Rats

Abdelsalam F. El.Sawy, Zinab K. El-Maddawy, Maha F. Gomaa.

Abstract
The present study was conducted to study the effect of ricobendazole on male fertility, as well as its effects on the liver and kidney functions tests, some hematological parameters and histopathological changes. Forty-five mature male albino rats were used and divided into 3 equal groups. The first group was kept as control and subcutaneously injected with proplyene glycol (2 ml /kg b.wt.). The second group was received a single subcutaneous injection of ricobendazole at a dose of 7.5 mg/kg bwt. The third group was subcutaneously injected with 7.5 mg / kg bwt twice within 3 weeks interval. The obtained results showed that administration of ricobendazole as single or repeated dose induced a variety of side effects on male reproduction as reduction of testes, epididymis, and accessory sex organs weights and change in sperm characters; decease of sperm count and motility, and increase in sperm abnormalities. liver functions test values such as Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and alkaline phosphatase (AlP) were significantly increased. Moreover, administration of ricobendazole induced histopathological alterations in reproductive organs, liver and kidney. The adverse effects of ricobendazole was more pronounced in repeated dose group. Therefore, caution is required when using repeated doses of ricobendazole

Key words: Ricobendzole – fertility – Male rats – biochemical changes


 
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How to Cite this Article
Pubmed Style

Abdelsalam F. El.Sawy, Zinab K. El-Maddawy , Maha F. Gomaa. Pharmacodynamics Studies on Ricobendazole In Male Rats. AJVS. 2014; 42(1): 36-48. doi:10.5455/ajvs.162332


Web Style

Abdelsalam F. El.Sawy, Zinab K. El-Maddawy , Maha F. Gomaa. Pharmacodynamics Studies on Ricobendazole In Male Rats. https://www.alexjvs.com/?mno=162332 [Access: December 07, 2023]. doi:10.5455/ajvs.162332


AMA (American Medical Association) Style

Abdelsalam F. El.Sawy, Zinab K. El-Maddawy , Maha F. Gomaa. Pharmacodynamics Studies on Ricobendazole In Male Rats. AJVS. 2014; 42(1): 36-48. doi:10.5455/ajvs.162332



Vancouver/ICMJE Style

Abdelsalam F. El.Sawy, Zinab K. El-Maddawy , Maha F. Gomaa. Pharmacodynamics Studies on Ricobendazole In Male Rats. AJVS. (2014), [cited December 07, 2023]; 42(1): 36-48. doi:10.5455/ajvs.162332



Harvard Style

Abdelsalam F. El.Sawy, Zinab K. El-Maddawy , Maha F. Gomaa (2014) Pharmacodynamics Studies on Ricobendazole In Male Rats. AJVS, 42 (1), 36-48. doi:10.5455/ajvs.162332



Turabian Style

Abdelsalam F. El.Sawy, Zinab K. El-Maddawy , Maha F. Gomaa. 2014. Pharmacodynamics Studies on Ricobendazole In Male Rats. Alexandria Journal of Veterinary Sciences, 42 (1), 36-48. doi:10.5455/ajvs.162332



Chicago Style

Abdelsalam F. El.Sawy, Zinab K. El-Maddawy , Maha F. Gomaa. "Pharmacodynamics Studies on Ricobendazole In Male Rats." Alexandria Journal of Veterinary Sciences 42 (2014), 36-48. doi:10.5455/ajvs.162332



MLA (The Modern Language Association) Style

Abdelsalam F. El.Sawy, Zinab K. El-Maddawy , Maha F. Gomaa. "Pharmacodynamics Studies on Ricobendazole In Male Rats." Alexandria Journal of Veterinary Sciences 42.1 (2014), 36-48. Print. doi:10.5455/ajvs.162332



APA (American Psychological Association) Style

Abdelsalam F. El.Sawy, Zinab K. El-Maddawy , Maha F. Gomaa (2014) Pharmacodynamics Studies on Ricobendazole In Male Rats. Alexandria Journal of Veterinary Sciences, 42 (1), 36-48. doi:10.5455/ajvs.162332





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