E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats

Ahmed A.M. Anwar, Hesham Z. Ibrahim, Sabah G. El –Banna.

Abstract
Mancozeb manganese ethylenebis dithiocarbamate polymeric complex – with zinc salts is a very important protective non-systemicfungicide, classified as an ethylenebisdithiocarbamate fungicide. It is used to control fungal diseases for a wide variety of crops because its broad-spectrum fungicidal effects and high compatibility with agrochemicals. The objective of this study was to investigate the effects of the fungicide mancozeb at different doses on some biochemical parameters, reproductive performance and histological changes in testes and thyroid gland. The low dose equal 1/7 of LD50 manc-d1 and high dose equal 1/3.5 of LD50 manc-d1. Doses of mancozeb (manc-d1 and manc-d2) adjusted according to rat's body weights. The results showed that mancozeb significantly (P<0.05) decreased plasma testosterone level, sperm count, viability, motility, and significantly (P<0.05) increased abnormal sperms, altered acrosome and abnormal DNA. Treatment of rats with manc-d1 and manc-d2 significantly (P<0.05) decreased T3. Also, T4 significantly (P<0.05) decreased in the group treated with manc-d2. Treatment of rats with manc-d1 and manc-d2 significantly (P<0.05) increased TSH. Furthermore, the histological investigation revealed that exposure to mancozeb reduced number of mature spermatozoa, necrosis and basal vacuoles observed in some tubules. On the other hand, mancozeb reduce colloid in most follicles resulting in desquamation of the follicular epithelium into the lumen of the thyroid follicles. In conclusion, despite mancozeb exhibit low acute toxicity, it has been shown to cause detrimental effects on reproduction, thyroid gland and its secretion. For this reason, it should be necessary to be careful when using mancozeb in agricultural areas and should take precautions.

Key words: Mancozeb, rats, thyroid glands, testes, histology, fungicidal -pesticide and Reproductive bioindicies


 
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How to Cite this Article
Pubmed Style

Anwar AA, Ibrahim HZ, -Banna SGE. Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats. AJVS. 2023; 77(1): 72-78. doi:10.5455/ajvs.117335


Web Style

Anwar AA, Ibrahim HZ, -Banna SGE. Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats. https://www.alexjvs.com/?mno=117335 [Access: December 05, 2023]. doi:10.5455/ajvs.117335


AMA (American Medical Association) Style

Anwar AA, Ibrahim HZ, -Banna SGE. Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats. AJVS. 2023; 77(1): 72-78. doi:10.5455/ajvs.117335



Vancouver/ICMJE Style

Anwar AA, Ibrahim HZ, -Banna SGE. Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats. AJVS. (2023), [cited December 05, 2023]; 77(1): 72-78. doi:10.5455/ajvs.117335



Harvard Style

Anwar, A. A., Ibrahim, . H. Z. & -Banna, . S. G. E. (2023) Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats. AJVS, 77 (1), 72-78. doi:10.5455/ajvs.117335



Turabian Style

Anwar, Ahmed A.M., Hesham Z. Ibrahim, and Sabah G. El -Banna. 2023. Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats. Alexandria Journal of Veterinary Sciences, 77 (1), 72-78. doi:10.5455/ajvs.117335



Chicago Style

Anwar, Ahmed A.M., Hesham Z. Ibrahim, and Sabah G. El -Banna. "Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats." Alexandria Journal of Veterinary Sciences 77 (2023), 72-78. doi:10.5455/ajvs.117335



MLA (The Modern Language Association) Style

Anwar, Ahmed A.M., Hesham Z. Ibrahim, and Sabah G. El -Banna. "Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats." Alexandria Journal of Veterinary Sciences 77.1 (2023), 72-78. Print. doi:10.5455/ajvs.117335



APA (American Psychological Association) Style

Anwar, A. A., Ibrahim, . H. Z. & -Banna, . S. G. E. (2023) Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats. Alexandria Journal of Veterinary Sciences, 77 (1), 72-78. doi:10.5455/ajvs.117335





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