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Original Article
Online Published: 30 Apr 2014
 


Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt

Mohamed A. Y. Helal, Hamada D.H. Mahboub, Shaaban A. Hemeda, Salah S. El Ballal, Hanim S. Heikal.


Abstract
Polymerase Chain Reaction-Restriction Fragment Length Polymorphisms (PCR–RFLP) and Single Nucleotide polymorphism (SNP) techniques were used to study the association between bone morphogenetic protein receptor IB (BMPR IB) gene polymorphism with litter size trait and kids growth. Forty four Female goats were precisely selected according to their litter size and kids growth. PCR amplification of 190 bp of the BMPR-IB gene was genotyped in all goats and sequenced only in those produced the highest and lowest litter size and kids growth. Restriction analysis of PCR-RFLP using Ava II and Hind III of the BMPR-IB gene (190-bp) do not produce restriction fragments. By DNA sequencing, eight single nucleotide polymorphisms (SNP’s) at seven different positions were obtained. Furthermore, with translation of SNPs to corresponding amino acids, change of six amino acids in three female goats were obtained as the flowing, Baladi goat with high litter size, glutamic acid (E) changed to aspartic acid (P) and isoleucine (I) changed to valine (V). In high litter size, Zaraibi goat, valine (V) changed to leucine acid (L) and glutamine (Q) changed to histidine (H). In another Zaraibi Goat with high litter size valine (V) changed to leucine acid (L) and threonine (T) changed to proline (P). These findings can be used in a marker-assisted selection (MAS) for selection for high litter size trait in goats. There are negative relationships in most goats between SNPs in BMPR IB gene and relative growth gain (RGG).

Key words: Goat, BMPR- IB gene, polymorphism


 
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How to Cite this Article
Pubmed Style

Mohamed A. Y. Helal, Hamada D.H. Mahboub, Shaaban A. Hemeda, Salah S. El Ballal, Hanim S. Heikal. Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt. AJVS. 2014; 41(1): 28-34. doi:10.5455/ajvs.155470

Web Style

Mohamed A. Y. Helal, Hamada D.H. Mahboub, Shaaban A. Hemeda, Salah S. El Ballal, Hanim S. Heikal. Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt. https://www.alexjvs.com/?mno=158714 [Access: September 13, 2024]. doi:10.5455/ajvs.155470

AMA (American Medical Association) Style

Mohamed A. Y. Helal, Hamada D.H. Mahboub, Shaaban A. Hemeda, Salah S. El Ballal, Hanim S. Heikal. Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt. AJVS. 2014; 41(1): 28-34. doi:10.5455/ajvs.155470


Vancouver/ICMJE Style

Mohamed A. Y. Helal, Hamada D.H. Mahboub, Shaaban A. Hemeda, Salah S. El Ballal, Hanim S. Heikal. Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt. AJVS. (2014), [cited September 13, 2024]; 41(1): 28-34. doi:10.5455/ajvs.155470


Harvard Style

Mohamed A. Y. Helal, Hamada D.H. Mahboub, Shaaban A. Hemeda, Salah S. El Ballal, Hanim S. Heikal (2014) Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt. AJVS, 41 (1), 28-34. doi:10.5455/ajvs.155470


Turabian Style

Mohamed A. Y. Helal, Hamada D.H. Mahboub, Shaaban A. Hemeda, Salah S. El Ballal, Hanim S. Heikal. 2014. Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt. Alexandria Journal of Veterinary Sciences, 41 (1), 28-34. doi:10.5455/ajvs.155470


Chicago Style

Mohamed A. Y. Helal, Hamada D.H. Mahboub, Shaaban A. Hemeda, Salah S. El Ballal, Hanim S. Heikal. "Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt." Alexandria Journal of Veterinary Sciences 41 (2014), 28-34. doi:10.5455/ajvs.155470


MLA (The Modern Language Association) Style

Mohamed A. Y. Helal, Hamada D.H. Mahboub, Shaaban A. Hemeda, Salah S. El Ballal, Hanim S. Heikal. "Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt." Alexandria Journal of Veterinary Sciences 41.1 (2014), 28-34. Print. doi:10.5455/ajvs.155470


APA (American Psychological Association) Style

Mohamed A. Y. Helal, Hamada D.H. Mahboub, Shaaban A. Hemeda, Salah S. El Ballal, Hanim S. Heikal (2014) Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt. Alexandria Journal of Veterinary Sciences, 41 (1), 28-34. doi:10.5455/ajvs.155470




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    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



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