E-ISSN 2536-9520 | ISSN 1110-2047
 
2024, Vol: 83
83Current Volume Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Original Article 


Behavioral, Maternal and Neurological Effects of Monosodium Glutamate on Pregnant Female Rats During Early and Late Gestation

Ahmed A. Ali, Hadeer M.E. Shosha.


Abstract
Seventy-five adult Wistar Albino rats were used in this experiment to detect the effect of MSG on fetus morphology, and pregnant rats’ behavioral, biochemecal, and neurological parameters. They were housed under standard laboratory conditions in plastic cages in a quiet environment with free access to food and water. They were randomly assigned into 4 groups of three replicates for each. Group (1) control, received normal saline. Groups (2, 3, and 4) received daily MSG orally at a dose of 1, 3 and 6 mg/kg respectively for a period of 20 days. There was a reduction in the mean number of fetuses /dam, an altered distribution of implantation, reduction in fetuses’ weight & length, besides some fetuses revealed morphological anomalies and skeletal defects at the 19th day of gestation. In addition, there was a decrease in the number of entrance and spontaneous alternations, increase in line crossing and rearing behaviors, elevation in serum ALT, AlP and creatinine, decrease in serum progesterone, increase in dopamine and glutamate levels (ng/mL) in brain tissues of MSG treated pregnant rats. So that, this study suggests that to diminish MSG in foods during pregnancy to to stay away from harmful effects on pregnant females behavior, brain tissue, and safe fetuses from deformity.

Key words: pregnant rat behavior, open field, Y maze, dopamine, and glutamate


 
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Pubmed Style

Ali AA, Shosha HM. Behavioral, Maternal and Neurological Effects of Monosodium Glutamate on Pregnant Female Rats During Early and Late Gestation. AJVS. 2024; 82(0): 101-109. doi:10.5455/ajvs.203761

Web Style

Ali AA, Shosha HM. Behavioral, Maternal and Neurological Effects of Monosodium Glutamate on Pregnant Female Rats During Early and Late Gestation. https://www.alexjvs.com/?mno=203761 [Access: December 02, 2024]. doi:10.5455/ajvs.203761

AMA (American Medical Association) Style

Ali AA, Shosha HM. Behavioral, Maternal and Neurological Effects of Monosodium Glutamate on Pregnant Female Rats During Early and Late Gestation. AJVS. 2024; 82(0): 101-109. doi:10.5455/ajvs.203761


Vancouver/ICMJE Style

Ali AA, Shosha HM. Behavioral, Maternal and Neurological Effects of Monosodium Glutamate on Pregnant Female Rats During Early and Late Gestation. AJVS. (2024), [cited December 02, 2024]; 82(0): 101-109. doi:10.5455/ajvs.203761


Harvard Style

Ali, A. A. & Shosha, . H. M. (2024) Behavioral, Maternal and Neurological Effects of Monosodium Glutamate on Pregnant Female Rats During Early and Late Gestation. AJVS, 82 (0), 101-109. doi:10.5455/ajvs.203761


Turabian Style

Ali, Ahmed A., and Hadeer M.E. Shosha. 2024. Behavioral, Maternal and Neurological Effects of Monosodium Glutamate on Pregnant Female Rats During Early and Late Gestation. Alexandria Journal of Veterinary Sciences, 82 (0), 101-109. doi:10.5455/ajvs.203761


Chicago Style

Ali, Ahmed A., and Hadeer M.E. Shosha. "Behavioral, Maternal and Neurological Effects of Monosodium Glutamate on Pregnant Female Rats During Early and Late Gestation." Alexandria Journal of Veterinary Sciences 82 (2024), 101-109. doi:10.5455/ajvs.203761


MLA (The Modern Language Association) Style

Ali, Ahmed A., and Hadeer M.E. Shosha. "Behavioral, Maternal and Neurological Effects of Monosodium Glutamate on Pregnant Female Rats During Early and Late Gestation." Alexandria Journal of Veterinary Sciences 82.0 (2024), 101-109. Print. doi:10.5455/ajvs.203761


APA (American Psychological Association) Style

Ali, A. A. & Shosha, . H. M. (2024) Behavioral, Maternal and Neurological Effects of Monosodium Glutamate on Pregnant Female Rats During Early and Late Gestation. Alexandria Journal of Veterinary Sciences, 82 (0), 101-109. doi:10.5455/ajvs.203761




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    About Alexandria Journal of Veterinary Sciences

    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



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    Egypt.

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