Complement Component C3 is a critical point in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.

Asmaa Aboelnour; Mohamed A. Elnasharty; Ahmed & 1613;S. Sayed-Ahmed; Glen Jeffery

doi:10.5455/ajvs.225699

2025, Vol: 86

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Original Article

AJVS. 0; 0(0):

doi: 10.5455/ajvs.225699

Complement Component C3 is a critical point in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.

Asmaa Aboelnour, Mohamed A. Elnasharty, Ahmed & 1613;s. Sayed-ahmed, Glen Jeffery.

Abstract
Deposition of extra cellular material is a feature of retinal ageing resulting in reduced outer retinal perfusion that can be associated with disease. This has been documented for Bruchs membrane (BM) and is elevated in mice that are complement factor H knock outs (Cfh-/-) and proposed as a model for macular degeneration. Here we ask if aged deposition occurs to the outer retinal blood supply before transmission across BM in 12 month old C57Bl and Cfh-/- mice and if differences exist at this level between these mice. We show arterial deposition of age related proteins complement component C3 with immunostaining and Western blot. Results showed deposition of C3 in all internal lamina of choroid blood vessels and three fragments were revealed from western blot which decrease significantly in Cfh-/- mice choroid

Key words: Choroid, Complement component C3, Immunostaining, Western blot

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Pubmed Style

Aboelnour A, Elnasharty MA, And A, Sayed-ahmed S, Jeffery G. Complement Component C3 is a critical point in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.. AJVS. 0; 0(0): -. doi:10.5455/ajvs.225699

Web Style

Aboelnour A, Elnasharty MA, And A, Sayed-ahmed S, Jeffery G. Complement Component C3 is a critical point in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.. https://www.alexjvs.com/?mno=225699 [Access: May 04, 2025]. doi:10.5455/ajvs.225699

AMA (American Medical Association) Style

Aboelnour A, Elnasharty MA, And A, Sayed-ahmed S, Jeffery G. Complement Component C3 is a critical point in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.. AJVS. 0; 0(0): -. doi:10.5455/ajvs.225699

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Harvard Style

Aboelnour, A., Elnasharty, . M. A., And, . A., Sayed-ahmed, . S. & Jeffery, . G. (0) Complement Component C3 is a critical point in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.. AJVS, 0 (0), -. doi:10.5455/ajvs.225699

Turabian Style

Aboelnour, Asmaa, Mohamed A. Elnasharty, Ahmed And, S. Sayed-ahmed, and Glen Jeffery. 0. Complement Component C3 is a critical point in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.. Alexandria Journal of Veterinary Sciences, 0 (0), -. doi:10.5455/ajvs.225699

Chicago Style

Aboelnour, Asmaa, Mohamed A. Elnasharty, Ahmed And, S. Sayed-ahmed, and Glen Jeffery. "Complement Component C3 is a critical point in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.." Alexandria Journal of Veterinary Sciences 0 (0), -. doi:10.5455/ajvs.225699

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