E-ISSN 2536-9520 | ISSN 1110-2047
 
2025, Vol: 85
85Current Volume Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Original Article 


Complement Component C3 is a critical point in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.

Asmaa Aboelnour, Mohamed A. Elnasharty, Ahmed & 1613;s. Sayed-ahmed, Glen Jeffery.


Abstract
Deposition of extra cellular material is a feature of retinal ageing resulting in reduced outer retinal perfusion that can be associated with disease. This has been documented for Bruch’s membrane (BM) and is elevated in mice that are complement factor H knock outs (Cfh-/-) and proposed as a model for macular degeneration. Here we ask if aged deposition occurs to the outer retinal blood supply before transmission across BM in 12 month old C57Bl and Cfh-/- mice and if differences exist at this level between these mice. We show arterial deposition of age related proteins complement component C3 with immunostaining and Western blot. Results showed deposition of C3 in all internal lamina of choroid blood vessels and three fragments were revealed from western blot which decrease significantly in Cfh-/- mice choroid

Key words: Choroid, Complement component C3, Immunostaining, Western blot


 
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How to Cite this Article
Pubmed Style

Aboelnour A, Elnasharty MA, And A, Sayed-ahmed S, Jeffery G. Complement Component C3 is a critical point in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.. AJVS. 0; 0(0): -. doi:10.5455/ajvs.225699

Web Style

Aboelnour A, Elnasharty MA, And A, Sayed-ahmed S, Jeffery G. Complement Component C3 is a critical point in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.. https://www.alexjvs.com/?mno=225699 [Access: March 25, 2025]. doi:10.5455/ajvs.225699

AMA (American Medical Association) Style

Aboelnour A, Elnasharty MA, And A, Sayed-ahmed S, Jeffery G. Complement Component C3 is a critical point in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.. AJVS. 0; 0(0): -. doi:10.5455/ajvs.225699


Vancouver/ICMJE Style

Aboelnour A, Elnasharty MA, And A, Sayed-ahmed S, Jeffery G. Complement Component C3 is a critical point in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.. AJVS. (0), [cited March 25, 2025]; 0(0): -. doi:10.5455/ajvs.225699


Harvard Style

Aboelnour, A., Elnasharty, . M. A., And, . A., Sayed-ahmed, . S. & Jeffery, . G. (0) Complement Component C3 is a critical point in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.. AJVS, 0 (0), -. doi:10.5455/ajvs.225699


Turabian Style

Aboelnour, Asmaa, Mohamed A. Elnasharty, Ahmed And, S. Sayed-ahmed, and Glen Jeffery. 0. Complement Component C3 is a critical point in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.. Alexandria Journal of Veterinary Sciences, 0 (0), -. doi:10.5455/ajvs.225699


Chicago Style

Aboelnour, Asmaa, Mohamed A. Elnasharty, Ahmed And, S. Sayed-ahmed, and Glen Jeffery. "Complement Component C3 is a critical point in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.." Alexandria Journal of Veterinary Sciences 0 (0), -. doi:10.5455/ajvs.225699


MLA (The Modern Language Association) Style

Aboelnour, Asmaa, Mohamed A. Elnasharty, Ahmed And, S. Sayed-ahmed, and Glen Jeffery. "Complement Component C3 is a critical point in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.." Alexandria Journal of Veterinary Sciences 0.0 (0), -. Print. doi:10.5455/ajvs.225699


APA (American Psychological Association) Style

Aboelnour, A., Elnasharty, . M. A., And, . A., Sayed-ahmed, . S. & Jeffery, . G. (0) Complement Component C3 is a critical point in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.. Alexandria Journal of Veterinary Sciences, 0 (0), -. doi:10.5455/ajvs.225699




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    About Alexandria Journal of Veterinary Sciences

    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



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    Faculty of Veterinary Medicine
    Alexandria University
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    Abees 10th district, Alexandria
    Egypt.

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