Myelin basic protein is down-regulated in sheep affected with ovine coenurosis

Mohamed El-Beskawy; Mohamed El-Adl; Mohamed Fawzy; Mayar Ali; moustafa Al-Araby

doi:10.5455/ajvs.245366

2025, Vol: 86

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Original Article

AJVS. 0; 0(0):

doi: 10.5455/ajvs.245366

Myelin basic protein is down-regulated in sheep affected with ovine coenurosis

Mohamed El-beskawy, Mohamed El-adl, Mohamed Fawzy, Mayar Ali, Moustafa Al-araby.

Abstract
Ovine coenurosis is a disease condition characterized by nervous manifestations that is associated with severe economic losses for sheep farm owners. This study was conducted to investigate the expression of myelin basic protein (MBP) gene in various regions of the brain in affected animals at different ages. We also studied the prevalence of coenurosis in Dakhlia governorate with parasitological and electron microscopic examinations to evaluate the severity of infestation. Ourresults revealed that MBP expression was downregulated in all brain regions at different ages. A hundred-fold reduction in MBP expression was observed in the cerebral cortex and a 500-fold decrease was observed in sheep older than one year. However, no differences were observed in MBP expression at different ages or different brain regions. Moreover, the highest prevalence of ovine coenurosis in Dakhlia governorate was in Belqas city in sheep aged more than 12 months with the highest incidence inthe cerebral cortex. Electron microscopic examination revealed demyelination in nerve tracts with the existence of gitter cells indicating the severity of coenurosis. From our results, we concluded that MBP is down-regulated in sheep affected with coenurosis and could serve as a novel marker for ovine coenurosis and other demyelinating diseases in sheep.

Key words: Ovine, Coenurosis, parasitic diseases, myelin basic protein

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Pubmed Style

El-beskawy M, El-adl M, Fawzy M, Ali M, Al-araby M. Myelin basic protein is down-regulated in sheep affected with ovine coenurosis. AJVS. 0; 0(0): -. doi:10.5455/ajvs.245366

Web Style

El-beskawy M, El-adl M, Fawzy M, Ali M, Al-araby M. Myelin basic protein is down-regulated in sheep affected with ovine coenurosis. https://www.alexjvs.com/?mno=245366 [Access: May 04, 2025]. doi:10.5455/ajvs.245366

AMA (American Medical Association) Style

El-beskawy M, El-adl M, Fawzy M, Ali M, Al-araby M. Myelin basic protein is down-regulated in sheep affected with ovine coenurosis. AJVS. 0; 0(0): -. doi:10.5455/ajvs.245366

Vancouver/ICMJE Style

El-beskawy M, El-adl M, Fawzy M, Ali M, Al-araby M. Myelin basic protein is down-regulated in sheep affected with ovine coenurosis. AJVS. (0), [cited May 04, 2025]; 0(0): -. doi:10.5455/ajvs.245366

Harvard Style

El-beskawy, M., El-adl, . M., Fawzy, . M., Ali, . M. & Al-araby, . M. (0) Myelin basic protein is down-regulated in sheep affected with ovine coenurosis. AJVS, 0 (0), -. doi:10.5455/ajvs.245366

Turabian Style

El-beskawy, Mohamed, Mohamed El-adl, Mohamed Fawzy, Mayar Ali, and Moustafa Al-araby. 0. Myelin basic protein is down-regulated in sheep affected with ovine coenurosis. Alexandria Journal of Veterinary Sciences, 0 (0), -. doi:10.5455/ajvs.245366

Chicago Style

El-beskawy, Mohamed, Mohamed El-adl, Mohamed Fawzy, Mayar Ali, and Moustafa Al-araby. "Myelin basic protein is down-regulated in sheep affected with ovine coenurosis." Alexandria Journal of Veterinary Sciences 0 (0), -. doi:10.5455/ajvs.245366

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

El-beskawy, M., El-adl, . M., Fawzy, . M., Ali, . M. & Al-araby, . M. (0) Myelin basic protein is down-regulated in sheep affected with ovine coenurosis. Alexandria Journal of Veterinary Sciences, 0 (0), -. doi:10.5455/ajvs.245366

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