E-ISSN 2536-9520 | ISSN 1110-2047
 
2025, Vol: 85
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Original Article 


Myelin basic protein is down-regulated in sheep affected with ovine coenurosis

Mohamed El-beskawy, Mohamed El-adl, Mohamed Fawzy, Mayar Ali, Moustafa Al-araby.


Abstract
Ovine coenurosis is a disease condition characterized by nervous manifestations that is associated with severe economic losses for sheep farm owners. This study was conducted to investigate the expression of myelin basic protein (MBP) gene in various regions of the brain in affected animals at different ages. We also studied the prevalence of coenurosis in Dakhlia governorate with parasitological and electron microscopic examinations to evaluate the severity of infestation. Ourresults revealed that MBP expression was downregulated in all brain regions at different ages. A hundred-fold reduction in MBP expression was observed in the cerebral cortex and a 500-fold decrease was observed in sheep older than one year. However, no differences were observed in MBP expression at different ages or different brain regions. Moreover, the highest prevalence of ovine coenurosis in Dakhlia governorate was in Belqas city in sheep aged more than 12 months with the highest incidence inthe cerebral cortex. Electron microscopic examination revealed demyelination in nerve tracts with the existence of gitter cells indicating the severity of coenurosis. From our results, we concluded that MBP is down-regulated in sheep affected with coenurosis and could serve as a novel marker for ovine coenurosis and other demyelinating diseases in sheep.

Key words: Ovine, Coenurosis, parasitic diseases, myelin basic protein


 
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How to Cite this Article
Pubmed Style

El-beskawy M, El-adl M, Fawzy M, Ali M, Al-araby M. Myelin basic protein is down-regulated in sheep affected with ovine coenurosis. AJVS. 0; 0(0): -. doi:10.5455/ajvs.245366

Web Style

El-beskawy M, El-adl M, Fawzy M, Ali M, Al-araby M. Myelin basic protein is down-regulated in sheep affected with ovine coenurosis. https://www.alexjvs.com/?mno=245366 [Access: March 25, 2025]. doi:10.5455/ajvs.245366

AMA (American Medical Association) Style

El-beskawy M, El-adl M, Fawzy M, Ali M, Al-araby M. Myelin basic protein is down-regulated in sheep affected with ovine coenurosis. AJVS. 0; 0(0): -. doi:10.5455/ajvs.245366


Vancouver/ICMJE Style

El-beskawy M, El-adl M, Fawzy M, Ali M, Al-araby M. Myelin basic protein is down-regulated in sheep affected with ovine coenurosis. AJVS. (0), [cited March 25, 2025]; 0(0): -. doi:10.5455/ajvs.245366


Harvard Style

El-beskawy, M., El-adl, . M., Fawzy, . M., Ali, . M. & Al-araby, . M. (0) Myelin basic protein is down-regulated in sheep affected with ovine coenurosis. AJVS, 0 (0), -. doi:10.5455/ajvs.245366


Turabian Style

El-beskawy, Mohamed, Mohamed El-adl, Mohamed Fawzy, Mayar Ali, and Moustafa Al-araby. 0. Myelin basic protein is down-regulated in sheep affected with ovine coenurosis. Alexandria Journal of Veterinary Sciences, 0 (0), -. doi:10.5455/ajvs.245366


Chicago Style

El-beskawy, Mohamed, Mohamed El-adl, Mohamed Fawzy, Mayar Ali, and Moustafa Al-araby. "Myelin basic protein is down-regulated in sheep affected with ovine coenurosis." Alexandria Journal of Veterinary Sciences 0 (0), -. doi:10.5455/ajvs.245366


MLA (The Modern Language Association) Style

El-beskawy, Mohamed, Mohamed El-adl, Mohamed Fawzy, Mayar Ali, and Moustafa Al-araby. "Myelin basic protein is down-regulated in sheep affected with ovine coenurosis." Alexandria Journal of Veterinary Sciences 0.0 (0), -. Print. doi:10.5455/ajvs.245366


APA (American Psychological Association) Style

El-beskawy, M., El-adl, . M., Fawzy, . M., Ali, . M. & Al-araby, . M. (0) Myelin basic protein is down-regulated in sheep affected with ovine coenurosis. Alexandria Journal of Veterinary Sciences, 0 (0), -. doi:10.5455/ajvs.245366




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    About Alexandria Journal of Veterinary Sciences

    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



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    Egypt.

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