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2025, Vol: 84
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Original Article
Online Published: 30 Nov 2016
 


Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis

Mohammed Elbeskawy, Mohamed El-Adl, Mohamed Hamed, Mayar Ali and Moustafa Al-Araby.


Abstract
Ovine coenurosis is a disease condition characterized by nervous manifestations that is associated with severe economic losses for sheep farm owners. This study was conducted to investigate the expression of myelin basic protein (MBP) gene in various regions of the brain in affected animals at different ages. We also studied the prevalence of coenurosis in Dakhlia governorate with parasitological and electron microscopic examinations to evaluate the severity of infestation. Ourresults revealed that MBP expression was down regulated in all brain regions at different ages. A hundred-fold reduction in MBP expression wasobserved in the cerebral cortex and a 500-fold decrease was observed in sheep older than one year. However, no differences were observed in MBP expression at different ages or different brain regions. Moreover, the highest prevalence of ovine coenurosis in Dakhlia governorate was in Belqas city in sheep aged more than 12 months with the highest incidence in the cerebral cortex. Electron microscopic examination revealed demyelination in nerve tracts with the existence of gitter cells indicating the severity of coenurosis. From these results, we concluded that MBP is down-regulated in sheep affected with coenurosis and could serve as a novel marker for ovine coenurosis and other demyelinating diseases in sheep.

Key words: Ovine, Coenurosis, parasitic diseases, myelin basic protein


 
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How to Cite this Article
Pubmed Style

Mohammed Elbeskawy, Mohamed El-Adl, Mohamed Hamed, Mayar Ali and Moustafa Al-Araby. Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis. AJVS. 2016; 51(1): 198-206. doi:10.5455/ajvs.245366

Web Style

Mohammed Elbeskawy, Mohamed El-Adl, Mohamed Hamed, Mayar Ali and Moustafa Al-Araby. Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis. https://www.alexjvs.com/?mno=250850 [Access: December 01, 2024]. doi:10.5455/ajvs.245366

AMA (American Medical Association) Style

Mohammed Elbeskawy, Mohamed El-Adl, Mohamed Hamed, Mayar Ali and Moustafa Al-Araby. Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis. AJVS. 2016; 51(1): 198-206. doi:10.5455/ajvs.245366


Vancouver/ICMJE Style

Mohammed Elbeskawy, Mohamed El-Adl, Mohamed Hamed, Mayar Ali and Moustafa Al-Araby. Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis. AJVS. (2016), [cited December 01, 2024]; 51(1): 198-206. doi:10.5455/ajvs.245366


Harvard Style

Mohammed Elbeskawy, Mohamed El-Adl, Mohamed Hamed, Mayar Ali and Moustafa Al-Araby (2016) Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis. AJVS, 51 (1), 198-206. doi:10.5455/ajvs.245366


Turabian Style

Mohammed Elbeskawy, Mohamed El-Adl, Mohamed Hamed, Mayar Ali and Moustafa Al-Araby. 2016. Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis. Alexandria Journal of Veterinary Sciences, 51 (1), 198-206. doi:10.5455/ajvs.245366


Chicago Style

Mohammed Elbeskawy, Mohamed El-Adl, Mohamed Hamed, Mayar Ali and Moustafa Al-Araby. "Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis." Alexandria Journal of Veterinary Sciences 51 (2016), 198-206. doi:10.5455/ajvs.245366


MLA (The Modern Language Association) Style

Mohammed Elbeskawy, Mohamed El-Adl, Mohamed Hamed, Mayar Ali and Moustafa Al-Araby. "Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis." Alexandria Journal of Veterinary Sciences 51.1 (2016), 198-206. Print. doi:10.5455/ajvs.245366


APA (American Psychological Association) Style

Mohammed Elbeskawy, Mohamed El-Adl, Mohamed Hamed, Mayar Ali and Moustafa Al-Araby (2016) Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis. Alexandria Journal of Veterinary Sciences, 51 (1), 198-206. doi:10.5455/ajvs.245366




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    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



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