The Role of Parapox virus (Zylexis) in Enhancing Humeral and Cellular Immune Response in Sheep Vaccinated with FMD Vaccine

Azza M. Mohamed; Mohamed H. Atwa; Eman R. Abdo; Diana M. Abul Magd

doi:10.5455/ajvs.259075

2025, Vol: 86

86Current Volume Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

« Previous Article

Original Article
Online Published: 12 Jun 2025

AJVS. 0; 0(0):

doi: 10.5455/ajvs.259075

The Role of Parapox virus (Zylexis) in Enhancing Humeral and Cellular Immune Response in Sheep Vaccinated with FMD Vaccine

Azza M. Mohamed, Mohamed H. Atwa, Eman R. Abdo, Diana M. Abul Magd.

Abstract
In this work, a trial was conducted to improve sheep reaction of the immune system to the inactivated FMD vaccination by using Zylexis as an immune-modulatory. Three groups of five sheep each were formed from the fifteen sheep. The first group received 2 injections of zylexis (2 ml/sheep, I/M) given on three days interval concurrently with vaccination with one dose of the inactivated FMD (SAT-2) vaccine (1ml/sheep, S/C); the second group got the vaccination and nothing else, while the third group served as a control and did not get any inoculation at all. To evaluate the humeral immune response, SNT and ELISA were used to serum samples, and blood samples obtained while taking heparin as an anticoagulant to assess the cellular immune response. Over the course of 40 weeks after vaccination, the findings showed that sheep given the inactivated zylexis vaccine had a stronger cellular and humoral immune response than sheep given the inactivated FMD (SAT-2) vaccine alone. In order to prolong the duration of immunity, it might be suggested to combine it with FMD vaccination. This would boost the immunological response of vaccinated animals.

Key words: FMD, SAT-2, Zylexis, SNT, ELISA,

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Azza M. Mohamed Articles by Mohamed H. Atwa Articles by Eman R. Abdo Articles by Diana M. Abul Magd
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Mohamed AM, Atwa MH, Abdo ER, Magd DMA. The Role of Parapox virus (Zylexis) in Enhancing Humeral and Cellular Immune Response in Sheep Vaccinated with FMD Vaccine. AJVS. Online First: 12 Jun, 2025. doi:10.5455/ajvs.259075

Web Style

Mohamed AM, Atwa MH, Abdo ER, Magd DMA. The Role of Parapox virus (Zylexis) in Enhancing Humeral and Cellular Immune Response in Sheep Vaccinated with FMD Vaccine. https://www.alexjvs.com/?mno=259075 [Access: June 19, 2025]. doi:10.5455/ajvs.259075

AMA (American Medical Association) Style

Mohamed AM, Atwa MH, Abdo ER, Magd DMA. The Role of Parapox virus (Zylexis) in Enhancing Humeral and Cellular Immune Response in Sheep Vaccinated with FMD Vaccine. AJVS. Online First: 12 Jun, 2025. doi:10.5455/ajvs.259075

Vancouver/ICMJE Style

Mohamed AM, Atwa MH, Abdo ER, Magd DMA. The Role of Parapox virus (Zylexis) in Enhancing Humeral and Cellular Immune Response in Sheep Vaccinated with FMD Vaccine. AJVS, [cited June 19, 2025]; Online First: 12 Jun, 2025. doi:10.5455/ajvs.259075

Harvard Style

Mohamed, A. M., Atwa, . M. H., Abdo, . E. R. & Magd, . D. M. A. (0) The Role of Parapox virus (Zylexis) in Enhancing Humeral and Cellular Immune Response in Sheep Vaccinated with FMD Vaccine. AJVS, Online First: 12 Jun, 2025. doi:10.5455/ajvs.259075

Turabian Style

Mohamed, Azza M., Mohamed H. Atwa, Eman R. Abdo, and Diana M. Abul Magd. 0. The Role of Parapox virus (Zylexis) in Enhancing Humeral and Cellular Immune Response in Sheep Vaccinated with FMD Vaccine. Alexandria Journal of Veterinary Sciences, Online First: 12 Jun, 2025. doi:10.5455/ajvs.259075

Chicago Style

Mohamed, Azza M., Mohamed H. Atwa, Eman R. Abdo, and Diana M. Abul Magd. "The Role of Parapox virus (Zylexis) in Enhancing Humeral and Cellular Immune Response in Sheep Vaccinated with FMD Vaccine." Alexandria Journal of Veterinary Sciences Online First: 12 Jun, 2025. doi:10.5455/ajvs.259075

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Mohamed, A. M., Atwa, . M. H., Abdo, . E. R. & Magd, . D. M. A. (0) The Role of Parapox virus (Zylexis) in Enhancing Humeral and Cellular Immune Response in Sheep Vaccinated with FMD Vaccine. Alexandria Journal of Veterinary Sciences, Online First: 12 Jun, 2025. doi:10.5455/ajvs.259075

About Alexandria Journal of Veterinary Sciences

Contact Information

How to cite this article