E-ISSN 2536-9520 | ISSN 1110-2047
 
2024, Vol: 83
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Original Article 


Effect of phenylbutazone on some hematological profiles, liver, kidney and reproductive organs in male rats

Abdelsalam fawzy elsawi, Zeynab . Khamis EL-Maddawy, ahmed usama bargal.


Abstract
The present study was conducted to study some pharmacodynamics and the possible adverse effects of Phenylbutazone and the toxic effects of its double dose in mature male rats . Haematological , biochemical and histopathological studies were carried out.
Mature male albino rats were used and divided into 3 equal groups each of 15 rats. Rats of the first group were kept as a control and intramuscularly injected with propylene glycol (2 ml ./kg b.wt.) once daily for 3 successive days . Rats of the second group were intramuscularly injected once daily for 3 successive days with Phenylbutazone at a dose of 53.3 mg./kg. b.wt. Rats of the third group were intramuscularly injected once daily for 3 successive days with Phenylbutazone at a dose of 106.6 mg/kg. b.wt .
Five rats from each control and treated groups were killed at 2 nd, 4 th and 8th week from beginning of drug administration to obtain blood, semen and some body organs for examination and evaluation .
The obtained results showed that i/ m administration of different doses of Phenylbutazone to male rats induced a variety of side effects on blood picture, biochemical and the reproductive parameters. Moreover, Phenylbutazone induced many histo-pathological alterations in the reproductive organs, liver and kidney of the treated male rats . Therefore, prolonged administration of Phenylbutazone should be avoided .

Key words: Key words: Phenylbutazone, liver, kidney, testes, rats, blood picture


 
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How to Cite this Article
Pubmed Style

elsawi Af, EL-Maddawy Z.K, bargal au. Effect of phenylbutazone on some hematological profiles, liver, kidney and reproductive organs in male rats. AJVS. 0; 0(0): -.

Web Style

elsawi Af, EL-Maddawy Z.K, bargal au. Effect of phenylbutazone on some hematological profiles, liver, kidney and reproductive organs in male rats. https://www.alexjvs.com/?mno=269398 [Access: September 12, 2024].

AMA (American Medical Association) Style

elsawi Af, EL-Maddawy Z.K, bargal au. Effect of phenylbutazone on some hematological profiles, liver, kidney and reproductive organs in male rats. AJVS. 0; 0(0): -.


Vancouver/ICMJE Style

elsawi Af, EL-Maddawy Z.K, bargal au. Effect of phenylbutazone on some hematological profiles, liver, kidney and reproductive organs in male rats. AJVS. (0), [cited September 12, 2024]; 0(0): -.


Harvard Style

elsawi, A. f., EL-Maddawy, . Z. .. K. & bargal, . a. u. (0) Effect of phenylbutazone on some hematological profiles, liver, kidney and reproductive organs in male rats. AJVS, 0 (0), -.


Turabian Style

elsawi, Abdelsalam fawzy, Zeynab . Khamis EL-Maddawy, and ahmed usama bargal. 0. Effect of phenylbutazone on some hematological profiles, liver, kidney and reproductive organs in male rats. Alexandria Journal of Veterinary Sciences, 0 (0), -.


Chicago Style

elsawi, Abdelsalam fawzy, Zeynab . Khamis EL-Maddawy, and ahmed usama bargal. "Effect of phenylbutazone on some hematological profiles, liver, kidney and reproductive organs in male rats." Alexandria Journal of Veterinary Sciences 0 (0), -.


MLA (The Modern Language Association) Style

elsawi, Abdelsalam fawzy, Zeynab . Khamis EL-Maddawy, and ahmed usama bargal. "Effect of phenylbutazone on some hematological profiles, liver, kidney and reproductive organs in male rats." Alexandria Journal of Veterinary Sciences 0.0 (0), -. Print.


APA (American Psychological Association) Style

elsawi, A. f., EL-Maddawy, . Z. .. K. & bargal, . a. u. (0) Effect of phenylbutazone on some hematological profiles, liver, kidney and reproductive organs in male rats. Alexandria Journal of Veterinary Sciences, 0 (0), -.




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    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



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