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Original Article
Online Published: 22 Jul 2018
 


Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens

Nagah Arafat, Walaa F. Awadin, Reham A. El-Shafei, Verginia M.E. Farag, Rasha M. Saleh.


Abstract
The present study was undertaken to evaluate the potential nephro- and hepato- protective as well as antioxidant effects of Moringa oleifera leaves extract (1% and 0.5%) against gentamicin induced toxicity (55 mg/kg body weight) in chickens. Growth performance, clinical signs, gross lesions, and mortality rates were evaluated at 1st, 2nd and 3rd weeks post gentamicin injection. Immune response, serum biochemical indices, antioxidant parameters and histopathology of liver and kidney were evaluated at 1st and 3rd weeks post gentamicin injection. Alterations in growth performance, immune response and oxidative stress markers in the liver and the kidney with increased mortality were observed in gentamicin treated group. Moreover, gentamicin exhibited a significant increase in serum hepatic and renal injury biomarkers as well as microscopic pathological lesions. However, Moringa oleifera leaves extract when given along with gentamicin, reversed the severity of gentamicin drawbacks, nephrotoxicity and hepatotoxicity by normalized the altered serum levels of liver and kidney biomarkers. Moreover, it reduced tissue nitric oxide and oxidative stress. In conclusion, the present study suggest that, Moringa oleifera leaves extract might play an important role in reducing oxidative stress, kidney and liver damage induced by gentamicin in chickens.

Key words: Antioxidant, chickens, gentamicin; Moringa oleifera, hepatotoxicity, nephrotoxicity


 
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How to Cite this Article
Pubmed Style

Arafat N, Awadin WF, El-Shafei RA, Farag VM, Saleh RM. Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens. AJVS. 2018; 58(1): 173-185. doi:10.5455/ajvs.299702

Web Style

Arafat N, Awadin WF, El-Shafei RA, Farag VM, Saleh RM. Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens. https://www.alexjvs.com/?mno=299702 [Access: December 02, 2024]. doi:10.5455/ajvs.299702

AMA (American Medical Association) Style

Arafat N, Awadin WF, El-Shafei RA, Farag VM, Saleh RM. Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens. AJVS. 2018; 58(1): 173-185. doi:10.5455/ajvs.299702


Vancouver/ICMJE Style

Arafat N, Awadin WF, El-Shafei RA, Farag VM, Saleh RM. Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens. AJVS. (2018), [cited December 02, 2024]; 58(1): 173-185. doi:10.5455/ajvs.299702


Harvard Style

Arafat, N., Awadin, . W. F., El-Shafei, . R. A., Farag, . V. M. & Saleh, . R. M. (2018) Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens. AJVS, 58 (1), 173-185. doi:10.5455/ajvs.299702


Turabian Style

Arafat, Nagah, Walaa F. Awadin, Reham A. El-Shafei, Verginia M.E. Farag, and Rasha M. Saleh. 2018. Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens. Alexandria Journal of Veterinary Sciences, 58 (1), 173-185. doi:10.5455/ajvs.299702


Chicago Style

Arafat, Nagah, Walaa F. Awadin, Reham A. El-Shafei, Verginia M.E. Farag, and Rasha M. Saleh. "Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens." Alexandria Journal of Veterinary Sciences 58 (2018), 173-185. doi:10.5455/ajvs.299702


MLA (The Modern Language Association) Style

Arafat, Nagah, Walaa F. Awadin, Reham A. El-Shafei, Verginia M.E. Farag, and Rasha M. Saleh. "Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens." Alexandria Journal of Veterinary Sciences 58.1 (2018), 173-185. Print. doi:10.5455/ajvs.299702


APA (American Psychological Association) Style

Arafat, N., Awadin, . W. F., El-Shafei, . R. A., Farag, . V. M. & Saleh, . R. M. (2018) Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens. Alexandria Journal of Veterinary Sciences, 58 (1), 173-185. doi:10.5455/ajvs.299702




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    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



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