E-ISSN 2536-9520 | ISSN 1110-2047
 
2026, Vol: 91
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Original Article
Online Published: 10 Sep 2026
 


A Comparative Study of Nanopolymer Derived from Small intestine Submucosa and Carbon Nanotubes for Reconstruction and Regeneration of Sciatic Nerve in Rat

Saddam K. Hummadi, Montaser M. Helal, Hiba A. Shekho, Ahmed A. Sultan.


Abstract
The current investigation sought to assess the efficacy of a nanopolymer derived from the small intestine submucosa (NSIS) for the regeneration and recovery of the neurectomized sciatic nerve. Thirty-two adult male rats were randomly assigned to two equal groups (n=16) following induction of left sciatic nerve neurotmesis with a 0.5 cm defect: in the first group, the transected nerves were coaptated using a silicone tube loaded with carbon nanotubes (CNTs group); in the second group, the transected nerves were coaptated with a silicone tube containing a nanopolymer of SIS (NSIS group).
Clinically, the animals of the NSIS group demonstrated a significant improvement (P ≤ 0.05) in motor and sensory functions with less tibialis anterior and gastrocnemius muscle atrophy when compared to the CNTs group during periods of assessment. The histopathological findings suggested that the disparities in nerve regeneration between the CNTs and NSIS groups may be ascribed to differences in Schwann cell quantity, diminished collagen fibers at the conduit site, enhanced nerve fiber orientation, and a reduction in nerve degeneration within the NSIS group. Additionally, the qRT-PCR results indicated that the NSIS considerably stimulated neurotrophics, including basic fibroblast growth factor (bFGF), ciliary neurotrophic factor (CNTF), and brain-derived neurotrophic factor (BDNF). In conclusion, NSIS provided a favorable microenvironment supporting regeneration and recovery of the neurotomized sciatic nerve.

Key words: Keywords: Carbon Nanotubes, Nanopolymer of SIS, Growth Factor, Sciatic Nerve.


 
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How to Cite this Article
Pubmed Style

Hummadi SK, Helal MM, Shekho HA, Sultan AA. A Comparative Study of Nanopolymer Derived from Small intestine Submucosa and Carbon Nanotubes for Reconstruction and Regeneration of Sciatic Nerve in Rat. AJVS. 2026; 91(0): 456-470. doi:10.5455/ajvs.326939

Web Style

Hummadi SK, Helal MM, Shekho HA, Sultan AA. A Comparative Study of Nanopolymer Derived from Small intestine Submucosa and Carbon Nanotubes for Reconstruction and Regeneration of Sciatic Nerve in Rat. https://www.alexjvs.com/?mno=326939 [Access: October 18, 2026]. doi:10.5455/ajvs.326939

AMA (American Medical Association) Style

Hummadi SK, Helal MM, Shekho HA, Sultan AA. A Comparative Study of Nanopolymer Derived from Small intestine Submucosa and Carbon Nanotubes for Reconstruction and Regeneration of Sciatic Nerve in Rat. AJVS. 2026; 91(0): 456-470. doi:10.5455/ajvs.326939


Vancouver/ICMJE Style

Hummadi SK, Helal MM, Shekho HA, Sultan AA. A Comparative Study of Nanopolymer Derived from Small intestine Submucosa and Carbon Nanotubes for Reconstruction and Regeneration of Sciatic Nerve in Rat. AJVS. (2026), [cited October 18, 2026]; 91(0): 456-470. doi:10.5455/ajvs.326939


Harvard Style

Hummadi, S. K., Helal, . M. M., Shekho, . H. A. & Sultan, . A. A. (2026) A Comparative Study of Nanopolymer Derived from Small intestine Submucosa and Carbon Nanotubes for Reconstruction and Regeneration of Sciatic Nerve in Rat. AJVS, 91 (0), 456-470. doi:10.5455/ajvs.326939


Turabian Style

Hummadi, Saddam K., Montaser M. Helal, Hiba A. Shekho, and Ahmed A. Sultan. 2026. A Comparative Study of Nanopolymer Derived from Small intestine Submucosa and Carbon Nanotubes for Reconstruction and Regeneration of Sciatic Nerve in Rat. Alexandria Journal of Veterinary Sciences, 91 (0), 456-470. doi:10.5455/ajvs.326939


Chicago Style

Hummadi, Saddam K., Montaser M. Helal, Hiba A. Shekho, and Ahmed A. Sultan. "A Comparative Study of Nanopolymer Derived from Small intestine Submucosa and Carbon Nanotubes for Reconstruction and Regeneration of Sciatic Nerve in Rat." Alexandria Journal of Veterinary Sciences 91 (2026), 456-470. doi:10.5455/ajvs.326939


MLA (The Modern Language Association) Style

Hummadi, Saddam K., Montaser M. Helal, Hiba A. Shekho, and Ahmed A. Sultan. "A Comparative Study of Nanopolymer Derived from Small intestine Submucosa and Carbon Nanotubes for Reconstruction and Regeneration of Sciatic Nerve in Rat." Alexandria Journal of Veterinary Sciences 91.0 (2026), 456-470. Print. doi:10.5455/ajvs.326939


APA (American Psychological Association) Style

Hummadi, S. K., Helal, . M. M., Shekho, . H. A. & Sultan, . A. A. (2026) A Comparative Study of Nanopolymer Derived from Small intestine Submucosa and Carbon Nanotubes for Reconstruction and Regeneration of Sciatic Nerve in Rat. Alexandria Journal of Veterinary Sciences, 91 (0), 456-470. doi:10.5455/ajvs.326939




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    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110-204 ... Read more.



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    Egypt.

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