E-ISSN 2536-9520 | ISSN 1110-2047
 
2025, Vol: 84
84Current Volume Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Original Article 


Solokap® (Herbaceutical formula) Protect Against Fluvastatin-Induced Hepatitis by Ameliorating Oxidative Stress and Inflammation in Female Albino Rats

Afrah F. Salama, Karim S. El Said, Ehab M. Tousson, Amro E. Mohamed.


Abstract
High doses of Fluvastatin (F) insure liver cells toxicity in hepatocytes function and homeostasis. This study investigated the possible therapeutic effect of solokap (S) on hepatitis induced by F in female rats. Animals were divided into four groups: group1 (negative control), group2 (F-control), group3, received solokap (S) only and group 4(F+S). Rats were received F for first 10 days. Results obtained showed that F increased alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AlP), gamma glutamyl transpeptidase (γ-GTP), total bilirubin, malondialdhyde (MDA), tumor necrosis factor α protein (TNFα), tumor growth factorβ1 (TGFβ1), nuclear factor Kappa B (NFKB), cyclooxygenase-1 and 2 (COX-1 and 2), while, decreased the levels of albumin and total protein, reduced glutathione (GSH), Glutathione peroxidase (GPx), catalase (CAT) and interleukin-10 protein (IL-10). Liver histological and immune-histochemical investigations of rats administered F showed sever congestion in portal vein associated with fibrosis and inflammatory cells infiltration. Also, collagen-I stained cells were found in the portal area and the central vein. On the other hand, animals treated with solokap showed improvements for these parameters as well as in the histological and immune-histochemical feature of the liver. Therefore, the present results revealed that Solokap could minimize the toxic effects of Fluvastatin.

Key words: Hepatitis, Fluvastatin, Solokap, Antioxidant enzymes, Inflammatory Responses


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Afrah F. Salama
Articles by Karim S. El Said
Articles by Ehab M. Tousson
Articles by Amro E. Mohamed
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Salama AF, Said KSE, Tousson EM, Mohamed AE. Solokap® (Herbaceutical formula) Protect Against Fluvastatin-Induced Hepatitis by Ameliorating Oxidative Stress and Inflammation in Female Albino Rats. AJVS. 2019; 62(1): 89-101. doi:10.5455/ajvs.47803

Web Style

Salama AF, Said KSE, Tousson EM, Mohamed AE. Solokap® (Herbaceutical formula) Protect Against Fluvastatin-Induced Hepatitis by Ameliorating Oxidative Stress and Inflammation in Female Albino Rats. https://www.alexjvs.com/?mno=47803 [Access: December 01, 2024]. doi:10.5455/ajvs.47803

AMA (American Medical Association) Style

Salama AF, Said KSE, Tousson EM, Mohamed AE. Solokap® (Herbaceutical formula) Protect Against Fluvastatin-Induced Hepatitis by Ameliorating Oxidative Stress and Inflammation in Female Albino Rats. AJVS. 2019; 62(1): 89-101. doi:10.5455/ajvs.47803


Vancouver/ICMJE Style

Salama AF, Said KSE, Tousson EM, Mohamed AE. Solokap® (Herbaceutical formula) Protect Against Fluvastatin-Induced Hepatitis by Ameliorating Oxidative Stress and Inflammation in Female Albino Rats. AJVS. (2019), [cited December 01, 2024]; 62(1): 89-101. doi:10.5455/ajvs.47803


Harvard Style

Salama, A. F., Said, . K. S. E., Tousson, . E. M. & Mohamed, . A. E. (2019) Solokap® (Herbaceutical formula) Protect Against Fluvastatin-Induced Hepatitis by Ameliorating Oxidative Stress and Inflammation in Female Albino Rats. AJVS, 62 (1), 89-101. doi:10.5455/ajvs.47803


Turabian Style

Salama, Afrah F., Karim S. El Said, Ehab M. Tousson, and Amro E. Mohamed. 2019. Solokap® (Herbaceutical formula) Protect Against Fluvastatin-Induced Hepatitis by Ameliorating Oxidative Stress and Inflammation in Female Albino Rats. Alexandria Journal of Veterinary Sciences, 62 (1), 89-101. doi:10.5455/ajvs.47803


Chicago Style

Salama, Afrah F., Karim S. El Said, Ehab M. Tousson, and Amro E. Mohamed. "Solokap® (Herbaceutical formula) Protect Against Fluvastatin-Induced Hepatitis by Ameliorating Oxidative Stress and Inflammation in Female Albino Rats." Alexandria Journal of Veterinary Sciences 62 (2019), 89-101. doi:10.5455/ajvs.47803


MLA (The Modern Language Association) Style

Salama, Afrah F., Karim S. El Said, Ehab M. Tousson, and Amro E. Mohamed. "Solokap® (Herbaceutical formula) Protect Against Fluvastatin-Induced Hepatitis by Ameliorating Oxidative Stress and Inflammation in Female Albino Rats." Alexandria Journal of Veterinary Sciences 62.1 (2019), 89-101. Print. doi:10.5455/ajvs.47803


APA (American Psychological Association) Style

Salama, A. F., Said, . K. S. E., Tousson, . E. M. & Mohamed, . A. E. (2019) Solokap® (Herbaceutical formula) Protect Against Fluvastatin-Induced Hepatitis by Ameliorating Oxidative Stress and Inflammation in Female Albino Rats. Alexandria Journal of Veterinary Sciences, 62 (1), 89-101. doi:10.5455/ajvs.47803




Most Viewed Articles
Most Accessed Articles

  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract » doi: 10.5455/ajvs.154650

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract » doi: 10.5455/ajvs.45443

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

    •
    Most Downloaded
    Top Downloaded Articles

  • Comparative Study of Cellular and Humoral Immune Response to BHV-1 Vaccines in Cattle and Buffalo Calves
    Fayrouz S. Naim; Samy A. Khalil and Helmy A. Torky
    AJVS. 2016; 51(2): 367-373
    » Abstract

  • Effect of Excess Fluoride on Reproductive Potentials in Farm Animals (Ovine)
    Ghada H. Abdel-Rahman, Hanaa A. El-Hallawany, Dohreig RA.
    AJVS. 2018; 57(2): 41-57
    » Abstract » doi: 10.5455/ajvs.296364

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Using of Polypropylene Mesh for Hernioplasty in Calves
    Mostafa M. kassam, Mahmoud H. Elkammer, Ahmed S. Korittum, Ali A. Abdel-Wahed
    AJVS. 2014; 40(1): 112-117
    » Abstract » doi: 10.5455/ajvs.47290

    •
    Most Cited Articles
    Most Cited Articles

    About Alexandria Journal of Veterinary Sciences

    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



    For best results, please use Internet Explorer or Google Chrome.

    Contact Information

    Faculty of Veterinary Medicine
    Alexandria University
    P.O.: 21944
    Abees 10th district, Alexandria
    Egypt.

    email: ajvs@alexu.edu.eg
    POLICIES & JOURNAL LINKS
    Author Login
    Reviewer Login
    About Publisher
    Advertising Policy
    Author's Rights and Obligations
    Conflict of Interest Policy
    Copyright Information
    Digital Archiving & Preservation Policies
    Editorial Policies
    Peer Review Policy
    Editorial & Peer Review Process
    License Information
    Open Access Policy
    Plagiarism Policy
    Privacy Policy
    Protection of Research Participants (Statement On Human And Animal Rights)
    Publication Ethics and Publication Malpractice Statement
    Corrections, Retractions & Expressions of Concern
    Self-Archiving Policies
    Statement of Informed Consent
    Terms of Use