The Possible Effect of Omega 3 Fatty Acids Against Cardiovascular Diseases in Rats: Biochemical and Histopathological Studies

Nada Sallai; Mohamed El-Adl; Gehad El-Sayed

doi:10.5455/ajvs.55680

2025, Vol: 86

86Current Volume Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

« Previous Article

Original Article

AJVS. 2019; 62(1): 130-136

doi: 10.5455/ajvs.55680

The Possible Effect of Omega 3 Fatty Acids Against Cardiovascular Diseases in Rats: Biochemical and Histopathological Studies

Nada Sallai, Mohamed El-adl, Gehad El-sayed.

Abstract
This research is designed for evaluation the effect of omega 3 poly unsaturated fatty acids (PUFA) on cardiovascular diseases (CVD) in rats. Thirty rats were divided into five groups each group contain six rats. The first group, control group, received control diet without any additives. The second group was injected with doxorubicin 2.5mg/kg b.wt in 6 injected equally and alternatively in 6 injections for 2 weeks. The third group was given omega 3 fish oil 400mg/kg b.wt daily for one month. The fourth group was injected with doxorubicin as second group, and then given omega 3 fatty acids for 2 weeks. The fifth group, was given fish oil omega 3 fatty acids for 2 weeks, and then was injected with dox as second group. Serum samples were collected for assessment of heart muscle function through (CK, LDH enzymes). Heart tissues were taken for histopathological examination, antioxidant enzymes activities determination, and gene expression. The result of CK and LDH concentration in serum showed significant elevation in DOX injected groups, decrease in groups received omega 3. SOD, GST and Catalase activities were elevated in groups received omega 3. GSH concentration was also elevated in groups received omega 3. The gene Rp6kb1 expression showed improvement in groups received omega 3. Finally, omega 3 have protective and therapeutic effect on cardiovascular diseases.

Key words: omega 3 fatty acids, Doxorubicin, cardiovascular diseases, cardiotoxicity

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Nada Sallai Articles by Mohamed El-Adl Articles by Gehad El-Sayed
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Sallai N, El-adl M, El-sayed G. The Possible Effect of Omega 3 Fatty Acids Against Cardiovascular Diseases in Rats: Biochemical and Histopathological Studies. AJVS. 2019; 62(1): 130-136. doi:10.5455/ajvs.55680

Web Style

Sallai N, El-adl M, El-sayed G. The Possible Effect of Omega 3 Fatty Acids Against Cardiovascular Diseases in Rats: Biochemical and Histopathological Studies. https://www.alexjvs.com/?mno=55680 [Access: May 03, 2025]. doi:10.5455/ajvs.55680

AMA (American Medical Association) Style

Sallai N, El-adl M, El-sayed G. The Possible Effect of Omega 3 Fatty Acids Against Cardiovascular Diseases in Rats: Biochemical and Histopathological Studies. AJVS. 2019; 62(1): 130-136. doi:10.5455/ajvs.55680

Vancouver/ICMJE Style

Sallai N, El-adl M, El-sayed G. The Possible Effect of Omega 3 Fatty Acids Against Cardiovascular Diseases in Rats: Biochemical and Histopathological Studies. AJVS. (2019), [cited May 03, 2025]; 62(1): 130-136. doi:10.5455/ajvs.55680

Harvard Style

Sallai, N., El-adl, . M. & El-sayed, . G. (2019) The Possible Effect of Omega 3 Fatty Acids Against Cardiovascular Diseases in Rats: Biochemical and Histopathological Studies. AJVS, 62 (1), 130-136. doi:10.5455/ajvs.55680

Turabian Style

Sallai, Nada, Mohamed El-adl, and Gehad El-sayed. 2019. The Possible Effect of Omega 3 Fatty Acids Against Cardiovascular Diseases in Rats: Biochemical and Histopathological Studies. Alexandria Journal of Veterinary Sciences, 62 (1), 130-136. doi:10.5455/ajvs.55680

Chicago Style

Sallai, Nada, Mohamed El-adl, and Gehad El-sayed. "The Possible Effect of Omega 3 Fatty Acids Against Cardiovascular Diseases in Rats: Biochemical and Histopathological Studies." Alexandria Journal of Veterinary Sciences 62 (2019), 130-136. doi:10.5455/ajvs.55680

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

About Alexandria Journal of Veterinary Sciences

Contact Information

How to cite this article