E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


Potential Ameliorative Effects of L-Carnitine on Imidacloprid-Induced Hepato- and Nephrotoxicity in Male Albino Rats

Alyaa R. Salama, Samah S. Oda, Samar S. Elblehi, Mohamed A. Hashem.

Abstract
The current study was intended to evaluate the possible protective role of L-Carnitine (LC) against imidacloprid (IM)-induced hepato- and nephrotoxicity in male albino rats. Thirty male albino rats were divided into 6 groups (n=5); control group, IM (32 mg/kg BW, 1/10 LD50)-treated group, LC200 (200 mg/kg BW)-treated group, LC400 (400 mg/kg BW)-treated group, IM+LC200-treated group, and IM+LC400-treated group. All treatments were given by oral route once daily for four weeks.
Hematologically, the results exhibited that IM administration induced a significant decrease in red blood cells (RBCs) count, hemoglobin (Hb) and hematocrit (Ht) values. The erythrocytic indices (MCV, MCH and MCHC) displayed non-significant change in all treated groups. However, IM-treated group showed a significant leukocytosis and thrombocytosis after four weeks of treatment as compared to control group. Biochemically, the results revealed that IM convinced a significant elevation of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma glutamyl transferase (GGT) activities, as well as serum total bilirubin (TB), direct bilirubin (DB) and indirect bilirubin (IB), globulins, urea, creatinine, potassium (K+), pro-inflammatory cytokines (tumor necrosis factor- alpha and interleukin-6) levels at the end of experiment matching with the control group. However, IM administration resulted in a significant diminution in the serum of total proteins (TP), albumin, and sodium (Na+) levels, with a significant increase and decrease respectively in the levels of lipid peroxidation and antioxidant biomarker in the hepatic and renal tissues of rats after four weeks of treatments as compared to control group. Histopathologically, IM administration revealed marked degenerative and necrotic alterations in the liver and kidney. Conversely, LC treatment at two doses (200 and 400 mg) ameliorated IM-induced alterations in the blood picture, oxidative damage and inflammation in the liver and kidneys.Finally, it could be concluded that treatment with LC at two doses (200 and 400 mg) ameliorated IM-induced oxidative damage, alterations in the hematology, liver and kidney function tests, as well as their histopathology. However, administration of LC at a dose of 400 mg/kg BW showed better protective effects against IM-induced hepato-nephrotoxicity as compared to the low dose (200 mg/kg BW).

Key words: Keywords: liver, kidneys, imidacloprid, L-Carnitine, rats.


 
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How to Cite this Article
Pubmed Style

Salama AR, Oda SS, Elblehi SS, Hashem MA. Potential Ameliorative Effects of L-Carnitine on Imidacloprid-Induced Hepato- and Nephrotoxicity in Male Albino Rats. AJVS. 2021; 70(1): 114-125. doi:10.5455/ajvs.64146


Web Style

Salama AR, Oda SS, Elblehi SS, Hashem MA. Potential Ameliorative Effects of L-Carnitine on Imidacloprid-Induced Hepato- and Nephrotoxicity in Male Albino Rats. https://www.alexjvs.com/?mno=64146 [Access: December 07, 2023]. doi:10.5455/ajvs.64146


AMA (American Medical Association) Style

Salama AR, Oda SS, Elblehi SS, Hashem MA. Potential Ameliorative Effects of L-Carnitine on Imidacloprid-Induced Hepato- and Nephrotoxicity in Male Albino Rats. AJVS. 2021; 70(1): 114-125. doi:10.5455/ajvs.64146



Vancouver/ICMJE Style

Salama AR, Oda SS, Elblehi SS, Hashem MA. Potential Ameliorative Effects of L-Carnitine on Imidacloprid-Induced Hepato- and Nephrotoxicity in Male Albino Rats. AJVS. (2021), [cited December 07, 2023]; 70(1): 114-125. doi:10.5455/ajvs.64146



Harvard Style

Salama, A. R., Oda, . S. S., Elblehi, . S. S. & Hashem, . M. A. (2021) Potential Ameliorative Effects of L-Carnitine on Imidacloprid-Induced Hepato- and Nephrotoxicity in Male Albino Rats. AJVS, 70 (1), 114-125. doi:10.5455/ajvs.64146



Turabian Style

Salama, Alyaa R., Samah S. Oda, Samar S. Elblehi, and Mohamed A. Hashem. 2021. Potential Ameliorative Effects of L-Carnitine on Imidacloprid-Induced Hepato- and Nephrotoxicity in Male Albino Rats. Alexandria Journal of Veterinary Sciences, 70 (1), 114-125. doi:10.5455/ajvs.64146



Chicago Style

Salama, Alyaa R., Samah S. Oda, Samar S. Elblehi, and Mohamed A. Hashem. "Potential Ameliorative Effects of L-Carnitine on Imidacloprid-Induced Hepato- and Nephrotoxicity in Male Albino Rats." Alexandria Journal of Veterinary Sciences 70 (2021), 114-125. doi:10.5455/ajvs.64146



MLA (The Modern Language Association) Style

Salama, Alyaa R., Samah S. Oda, Samar S. Elblehi, and Mohamed A. Hashem. "Potential Ameliorative Effects of L-Carnitine on Imidacloprid-Induced Hepato- and Nephrotoxicity in Male Albino Rats." Alexandria Journal of Veterinary Sciences 70.1 (2021), 114-125. Print. doi:10.5455/ajvs.64146



APA (American Psychological Association) Style

Salama, A. R., Oda, . S. S., Elblehi, . S. S. & Hashem, . M. A. (2021) Potential Ameliorative Effects of L-Carnitine on Imidacloprid-Induced Hepato- and Nephrotoxicity in Male Albino Rats. Alexandria Journal of Veterinary Sciences, 70 (1), 114-125. doi:10.5455/ajvs.64146





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