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2025, Vol: 84
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Original Article
Online Published: 16 Dec 2019
 


The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken

Sherin AboSaleh, Mohamed F. Salama, El-Said El-Sherbini, Maha Z. Hassan.


Abstract
The efficacy of Nigella sativa as an ameliorative medicinal plant with anticancer and antioxidant effects has drawn the attention of many researchers. The aim of this study was to examine the potential protective effect of Nigella sativa against aflatoxin-induced liver damage in chicken. A total of 40 broiler chickens were randomly divided into four groups (G1-G4). Chicks in G1 were fed on normal ration, G2 were fed on ration supplemented with 0.3 mg AFB1/kg feed, G3 were fed on ration supplemented with 1% Nigella sativa. Finally, birds in G4 were fed on a ration supplemented with 0.3 mg AFB1/kg and 1% Nigella sativa. Birds were sacrificed at the end of the experimental period (four weeks); the serum and liver were harvested for biochemical, histological and gene expression analyses. Our results showed that Nigella sativa alleviates the toxic effects of Aflatoxins by antagonizing lipid peroxidation, oxidative stress and apoptosis by modulating the expression of antiapoptotic BCL-2 and pro-apoptotic BAX. Moreover, Nigella sativa exhibited anti-inflammatory effect as evidenced by restoring proinflammatory cytokines levels. Nigella sativa can be used as a feed additive to poultry diets to alleviate any potential aflatoxin toxicity from contaminated diets.

Key words: Aflatoxins; Broilers; Nigella sativa; Liver damage; Apoptosis


 
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How to Cite this Article
Pubmed Style

AboSaleh S, Salama MF, El-Sherbini E, Hassan MZ. The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken. AJVS. 2019; 63(2): 113-120. doi:10.5455/ajvs.73879

Web Style

AboSaleh S, Salama MF, El-Sherbini E, Hassan MZ. The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken. https://www.alexjvs.com/?mno=73879 [Access: December 01, 2024]. doi:10.5455/ajvs.73879

AMA (American Medical Association) Style

AboSaleh S, Salama MF, El-Sherbini E, Hassan MZ. The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken. AJVS. 2019; 63(2): 113-120. doi:10.5455/ajvs.73879


Vancouver/ICMJE Style

AboSaleh S, Salama MF, El-Sherbini E, Hassan MZ. The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken. AJVS. (2019), [cited December 01, 2024]; 63(2): 113-120. doi:10.5455/ajvs.73879


Harvard Style

AboSaleh, S., Salama, . M. F., El-Sherbini, . E. & Hassan, . M. Z. (2019) The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken. AJVS, 63 (2), 113-120. doi:10.5455/ajvs.73879


Turabian Style

AboSaleh, Sherin, Mohamed F. Salama, El-Said El-Sherbini, and Maha Z. Hassan. 2019. The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken. Alexandria Journal of Veterinary Sciences, 63 (2), 113-120. doi:10.5455/ajvs.73879


Chicago Style

AboSaleh, Sherin, Mohamed F. Salama, El-Said El-Sherbini, and Maha Z. Hassan. "The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken." Alexandria Journal of Veterinary Sciences 63 (2019), 113-120. doi:10.5455/ajvs.73879


MLA (The Modern Language Association) Style

AboSaleh, Sherin, Mohamed F. Salama, El-Said El-Sherbini, and Maha Z. Hassan. "The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken." Alexandria Journal of Veterinary Sciences 63.2 (2019), 113-120. Print. doi:10.5455/ajvs.73879


APA (American Psychological Association) Style

AboSaleh, S., Salama, . M. F., El-Sherbini, . E. & Hassan, . M. Z. (2019) The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken. Alexandria Journal of Veterinary Sciences, 63 (2), 113-120. doi:10.5455/ajvs.73879




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    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



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    Egypt.

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