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Original Article
Online Published: 27 Mar 2022
 


Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats

Hayam O. Mosolin, El-Sayed E. Mehana, Samah S. Oda, Samar S. Elblehi, Dina R. Gad El-Karim.


Abstract
This study was carried out to evaluate the presumptive ameliorative effect of Green tea (GT) and Quercetin (Q) against Cadmium (Cd) induced hepato-renal toxicity in rats. Sixty male albino rats were randomly divided into 6 groups (n=10); control group: orally received distilled water, Cd-treated group: orally received CdCl2 (5 mg/kg b.wt./day, 3 times /week), GT-treated group: orally received GT extract (200 mg/kg b.wt./day 3 times / week), Q-treated group: orally received Q (50 mg/kg b.wt./day 3 times / week), Cd+GT and Cd+Q -treated groups received a combination of cadmium, green tea extract or quercetin at the same previous doses and routes. All the experimental procedures were continued for eight weeks. Intoxication with cadmium revealed a significant elevation in serum liver enzymes, total and direct bilirubin with a significant decrease in serum levels of total proteins and albumin. Also, there was a significant elevation in serum urea and creatinine levels. In addition to, the Cd exhibited severe oxidative stress that represented by a significant increase in renal and hepatic malondialdhyde (MDA) and a significant decrease in reduced glutathione (GSH) and catalase (CAT). Histopathologically, Cd revealed severe degenerative and necrotic lesions in the livers and kidneys. The mixed treatment with GT and Q- attenuated Cd-induced oxidative stress, serum biochemical alterations related to hepato-renal damge and histopathological changes in liver and kidney. However, the co-treatment with Q showed better protection than GT against Cd induced toxicity in rats.
Keywords: Cadmium, green tea, quercetin, rats, hepato-renal toxicity.

Key words: s: Cadmium, green tea, quercetin, rats, hepato-renal toxicity.


 
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How to Cite this Article
Pubmed Style

Mosolin HO, Mehana EE, Oda SS, Elblehi SS, El-Karim DRG. Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats. AJVS. 2022; 73(1): 101-110. doi:10.5455/ajvs.11657

Web Style

Mosolin HO, Mehana EE, Oda SS, Elblehi SS, El-Karim DRG. Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats. https://www.alexjvs.com/?mno=11657 [Access: September 13, 2024]. doi:10.5455/ajvs.11657

AMA (American Medical Association) Style

Mosolin HO, Mehana EE, Oda SS, Elblehi SS, El-Karim DRG. Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats. AJVS. 2022; 73(1): 101-110. doi:10.5455/ajvs.11657


Vancouver/ICMJE Style

Mosolin HO, Mehana EE, Oda SS, Elblehi SS, El-Karim DRG. Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats. AJVS. (2022), [cited September 13, 2024]; 73(1): 101-110. doi:10.5455/ajvs.11657


Harvard Style

Mosolin, H. O., Mehana, . E. E., Oda, . S. S., Elblehi, . S. S. & El-Karim, . D. R. G. (2022) Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats. AJVS, 73 (1), 101-110. doi:10.5455/ajvs.11657


Turabian Style

Mosolin, Hayam O., El-Sayed E. Mehana, Samah S. Oda, Samar S. Elblehi, and Dina R. Gad El-Karim. 2022. Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats. Alexandria Journal of Veterinary Sciences, 73 (1), 101-110. doi:10.5455/ajvs.11657


Chicago Style

Mosolin, Hayam O., El-Sayed E. Mehana, Samah S. Oda, Samar S. Elblehi, and Dina R. Gad El-Karim. "Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats." Alexandria Journal of Veterinary Sciences 73 (2022), 101-110. doi:10.5455/ajvs.11657


MLA (The Modern Language Association) Style

Mosolin, Hayam O., El-Sayed E. Mehana, Samah S. Oda, Samar S. Elblehi, and Dina R. Gad El-Karim. "Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats." Alexandria Journal of Veterinary Sciences 73.1 (2022), 101-110. Print. doi:10.5455/ajvs.11657


APA (American Psychological Association) Style

Mosolin, H. O., Mehana, . E. E., Oda, . S. S., Elblehi, . S. S. & El-Karim, . D. R. G. (2022) Ameliorative Effect of Green tea and Quercetin against Cadmium-Induced Hepato-Renal Toxicity in Rats. Alexandria Journal of Veterinary Sciences, 73 (1), 101-110. doi:10.5455/ajvs.11657




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