A review: Multiple Sclerosis Treatment: Current Strategies and Future Hopes

Ashraf A. Shamaa; Ahmed N. Abdallah; Mohamed M. Bahr; Omar S. El-Tookhy

doi:10.5455/ajvs.125962

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AJVS. 2020; 66(2): 30-39

doi: 10.5455/ajvs.125962

A review: Multiple Sclerosis Treatment: Current Strategies and Future Hopes

Ashraf A. Shamaa, Ahmed N. Abdallah, Mohamed M. Bahr, Omar S. El-tookhy.

Abstract
Multiple sclerosis (MS) is a chronic autoimmune disease which influences the neurons of the central nervous system by chronic demyelination. The immune system attacks the myelin sheath and the oligodendrocyte leading to oligodendroglial cells loss, glial scarring and the remyelination stops setting off irreversible damage. The MS is classified into 4 categories: Relapsingremitting which is considered the most common (about 85% of cases), Secondary progressive, Primary progressive and Progressive-relapsing. The treatment of MS with disease-modifying agents aims to shorten the duration of acute relapses and decreasing relapses frequency. Until now, no curative FDA-approved therapies exist, but there are 8 FDA-approved therapeutic agents able to reduce the disease progression in the relapsing forms of MS. The available therapies are immunosuppressive or immunomodulatory drugs which preclude or delay MS progression. Regenerative medicine via MSCs could play an important role in regeneration a damaged neural tissue as MSCs not only have ability for neurogeneration but also have immunoregulative function which can control and treat MS. Exosomes derived from MSCs offer a good alternative surpassing the possible drawbacks of using MSCs such as tumorigenicity and immune rejection.

Key words: MS-treatments, regenerative-drugs, MSCs, exosomes.

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Pubmed Style

Shamaa AA, Abdallah AN, Bahr MM, El-tookhy OS. A review: Multiple Sclerosis Treatment: Current Strategies and Future Hopes. AJVS. 2020; 66(2): 30-39. doi:10.5455/ajvs.125962

Web Style

Shamaa AA, Abdallah AN, Bahr MM, El-tookhy OS. A review: Multiple Sclerosis Treatment: Current Strategies and Future Hopes. https://www.alexjvs.com/?mno=125962 [Access: May 04, 2025]. doi:10.5455/ajvs.125962

AMA (American Medical Association) Style

Shamaa AA, Abdallah AN, Bahr MM, El-tookhy OS. A review: Multiple Sclerosis Treatment: Current Strategies and Future Hopes. AJVS. 2020; 66(2): 30-39. doi:10.5455/ajvs.125962

Vancouver/ICMJE Style

Shamaa AA, Abdallah AN, Bahr MM, El-tookhy OS. A review: Multiple Sclerosis Treatment: Current Strategies and Future Hopes. AJVS. (2020), [cited May 04, 2025]; 66(2): 30-39. doi:10.5455/ajvs.125962

Harvard Style

Shamaa, A. A., Abdallah, . A. N., Bahr, . M. M. & El-tookhy, . O. S. (2020) A review: Multiple Sclerosis Treatment: Current Strategies and Future Hopes. AJVS, 66 (2), 30-39. doi:10.5455/ajvs.125962

Turabian Style

Shamaa, Ashraf A., Ahmed N. Abdallah, Mohamed M. Bahr, and Omar S. El-tookhy. 2020. A review: Multiple Sclerosis Treatment: Current Strategies and Future Hopes. Alexandria Journal of Veterinary Sciences, 66 (2), 30-39. doi:10.5455/ajvs.125962

Chicago Style

Shamaa, Ashraf A., Ahmed N. Abdallah, Mohamed M. Bahr, and Omar S. El-tookhy. "A review: Multiple Sclerosis Treatment: Current Strategies and Future Hopes." Alexandria Journal of Veterinary Sciences 66 (2020), 30-39. doi:10.5455/ajvs.125962

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Shamaa, A. A., Abdallah, . A. N., Bahr, . M. M. & El-tookhy, . O. S. (2020) A review: Multiple Sclerosis Treatment: Current Strategies and Future Hopes. Alexandria Journal of Veterinary Sciences, 66 (2), 30-39. doi:10.5455/ajvs.125962

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