E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


Morphogenesis of Rabbit Kidney Pre-and Postnatal

Sahar E. Fayez, Ahmed Sayed-Ahmed, Ismail I. Abo-Ghanema, Mohamed A. Elnasharty.

Cited by (1)

Abstract
Mammalian renal development differs from that of most of the other organs in that it proceeds through a series of three successive phases, each is marked by the formation of a more complex pair of kidneys. These kidneys are called the pronephros, mesonephros, and metanephros. The current study has been conducted to elucidate the developmental changes of rabbit kidneys during their pre- and postnatal life. In the present study we used samples, at different ages, of the rabbit kidneys from embryonic day 15 (E15) till maturity for light and scanning electron microscopical investigation. At E15, large mesonephros, occupied a great part of abdominal cavity of rabbit embryo, and undifferentiated metanephros were noticed. At E19 metanephros became differentiated into cortex and medulla with the initiation of nephron-forming stage. Additionally at this stage, the caudal series of mesonephros still detected but in degenerated and atrophied structure. Just before birth, at E30, the kidney demonstrated well-developed renal corpuscles, differentiated proximal and distal convoluted tubules, with apparently detectable loop of Henle and large collecting ducts. Shortly after birth rabbit kidney showed further morphogenesis and at two-months old, the kidney of rabbit with mature histological structure of the renal parenchyma was documented. In conclusion, the development of rabbit kidneys occurred mainly during the prenatal period while their histological maturity occurred from two to three weeks after birth. The present findings were discussed with previous publications.

Key words: rabbit, kidney, morphogenesis, mesonephros, metanephros


 
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REFERENCES
•Al- yasery, A. (2007). Developmental study for Embryological formation of kidneys in the Embryos of white Swiss mice. MSC Thesis, the University of Basra, Iraq.
•Al-Awdan, E. and Kandil, A. (1979). Prenatal development of the kidney of the rat. J Vet Sci 8:50-60.
•Bacha, W. and Bacha, L. (2000). Color Atlas of Veterinary Histology. 2nd ed. D. Balado. Lippincott Williams and Wilkins, Maryland, pp: 163-74.
•Blomqvist, S., Vidarsson, H., Fitzgerald, S., Johansson, B., Ollerstam, A., Brown, R., Persson, A., Bergstrom, G. and Enerback, S. (2004). Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1. J Clin Invest 113:1560–70.
•Bridgewater D., Cox B., Cain J., Lau A., Athaide V., Gill P., Kuure S., Sainio K., Rosenblum N. (2008). Canonical WNT/beta-catenin signaling is required for ureteric branching. Dev Biol 317:83– 94.
•Carroll T.J. Park J.S. Hayashi S. Majumdar A. McMahon A. P. (2005). Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell 9:283–92.
•Cebrian, C; Borodo, K., Charles, N. and Herzlinger, D. (2004). Morphometric index of the developing murine kidney. Dev Dyn 231:601-8.
•Chaudhury, A., Farooqui, M. and Chandra, P. (2006). Histological and histochemical studies on the metanephros of goat (Capra hircus) in prenatal period –excretory part. The Indian Journal of Small Ruminants 12:9710- 57.
•Cheng, H. and Kopan, R. (2005). The role of Notch signaling in specification of podocyte and proximal tubules within the developing mouse kidney. Kidney Int 68:1951-52.
•Cheng, H., Miner, J., Lin, M., Tansey, M., Roth, K. and Kopan, R. (2003). Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney. Development 130:5031-42.
•De Martino, C. and Zamboni, L. (1966). A morphologic study of the mesonephros of the human embryo. J Ultrast Res 16:399-427.
•Dellmann, H. and Brown, E. (2006). Text book of Veterinary histology; Urinary System. 6th ed, Blackwell Publishing Professional, State Avenue, Ames, Iowa 50014, USA.
•Dickinson, H. Walker, D.. Cullen- McEwen, L. Wintour, E. and Mortiz, K. (2005). The spiny mouse (Acomys cahirinus) completes nephrogenesis before birth. Amer J Phys Ren Phys 289:273-79.
•Du Bois, A. (1969). The embryonic kidney. In The Kidney, ed. C. Rouiller and A. F. Muller, vol. I, pp. 1-59. Academic Press, New York.
•Evan A., Gattone V., Biomgren P. (1984). Application of scanning electron microscopy to kidney development and nephron maturation. Scan Electron Microsc 1:455-73.
•Fisher, C., Michael, L., Barnett, M., and Davies, J. (2001). Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney. Development 128:4329-38.
•Fouser M., Fouser L., and Avner E. (1993). Normal and abnormal nephrogenesis. Am J Kid Dis 21:64-70.
•Friebova-Zemanova, Z. and Concharevskaya, O. (1982). Formation of the chick mesonephros. 5. Spatial distribution of the nephron populations. Anat Embryol 164:125-39.
•Guron G., Nilsson A., Nitescu N., Nielsen S., Sundelin B., Frøkiaer J., and Friberg P. (1999). Mechanisms of impaired urinary concentrating ability in adult rats treated neonatally with enalapril. Acta Physiol Scand 165:103-12.
•Hamilton, H. (1952). Lillie's Development of the Chick. Henry Holt, New York.
•Hebert, S., Reilly, R., and Kriz, W. (2001). Structural-Functional Relationships in the Kidney. In: Schrier, R. W., editor. Diseases of the Kidney and Urinary Tract. Philadelphia, Lippincott: Williams and Wilkins. pp. 3–58.
•Jafar, G. and Farhan, O. (2012): Histomorphological study of tubular system and collecting tubules in domestic rabbit's fetuses (Oryctolagus cuniculus). Kufa J Vet Med Sci 3:67-76
• Kasimierczak, J. (1971). Development of the renal corpuscle and the juxta-glomerular apparatus: a light and electron microscopic study. Acta Pathol Microbial Scand Suppl 218.
• Kasimierczak, J. (1976). Developpement du glomerule renal en microscopie electronique a transmission et a balayage. Bull Assoc Anat 60:137-143.
•Kavlock R. and Gray J. (1982). Evaluation of renal function in neonatal rats. Biol Neonate 41:279-88.
• Larsson, L. (1975). The ultrastructure of the developing proximal tubule in the rat kidney. Ultrastruct Res 51:119-39.
•Latshaw W. (1987). Veterinary developmental anatomy; a clinically oriented approach. B. C. Decker INC. pp 231-35.
•Leeson, T. and Baxter, J. (1957). The correlation of structure and function in the mesonephros and metanephros of the rabbit. J Anat 91:383-90.
•Leimeister, C., Schumacher, N. and Gessler, M. (2003). Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development. Gene Expr Patterns 3:595-98.
•Majumdar A., Vainio S., Kispert A., McMahon J., McMahon A. (2003). Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development 130:3175–85.
•Marin-Padilla, M. (1964). The mesonephric-testicular connection in man and some mammals. Anat Rec 148:1-14.
•McCright, B., Lozier, J. and Gridley, T. (2002). A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency. Development 129:1075-82.
•Mcgeady, T., Quinn, P., Fitzpatrick, E. and Ryan, M. (2010). Veterinary embryology. Blackwell publishing Ltd. Pp 233-43.
•Neiss, W (1982). Histogenesis of the loop of Henle in the rat kidney. Anat Embryol 164:315–30
•Noden D. and de Lahunta A. (1985). The embryology of domestic animals; developmental mechanisms and malformation. Williams and Wilkins pp 312-21.
•Patel, S., and Dressler, G. (2013): The Genetics and Epigenetics of Kidney Development. 33:314–26.
•Potter, E. (1965). Development of the human glomerulus. Arch Pathol 80:241-55.
•Potter, E. (1972). Normal and Abnormal Development of the Kidney. Year Book Medical Publ. Inc. Chicago.
•Quaggin, S., and Kreidberg, J. (2008). Development of the renal glomerulus: good neighbors and good fences. Development 135:609–20.
•Sainio, K. (2003). Development of the mesonephric kidney. In: Vize, C., Woolf, A. S, and Bard, J. B. L., editors. The kidney. From normal development to congenital disease. London: Academic Press. pp. 75–86.
•Sainio, K., Hellstedt, P., Kreidberg, J., Saxen, L., and Sariola, H. (1997). Differential regulation of two sets of mesonephric tubules by WT-1. Development 124:1293–99.
•Saxen, L. (1987). Organogenesis of the Kidney, volume 19, ed. P. W. Barlow, P. B. Green and C. C. White) Cambridge: Cambridge University Press.
•Schiller, A. and Tiedemann, K. (1981). The mature mesonephric nephron of the rabbit embryo. III. Freeze-fracture studies. Cell Tissue Res 221:431-42.
•Schwartz, G., Olson J., Kittelberger A., Matsumoto T., Waheed A., Sly W. (1999). Postnatal development of carbonic anhydrase IV expression in rabbit kidney. Amer J Physiol 276:510-20.
•Seikaly M., Arant B. (1992). Development of renal hemodynamics: glomerular filtration and renal blood flow. Clin Perinatol 19:1-13.
•Silverman, H. (1969). Uber die Entwicklung der Epithelplatten in den Corpuscula renalia der menschlichen Uriniere. Acta Anat 74:36-43.
•Smith, C., and Mackay, S. (1991). Morphological development and fate of the mouse mesonephros. J Anat 174:171–84.
•Stark K., Vainio S., Vassileva G. and McMahon A. (1994). Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature 372:679–83.
•Tiedemann, K. (1976). The mesonephros of cat and sheep. Comparative morphological and histochemical studies. In Advances in Anatomy, Embryology and Cell Biology, ed. A. Brodal, W. Hild, J. van Limborgh, R. Ortmann, T. H. Schiebler, G. Tondury and E. Wolff, pp. 1-119. Springer-Verlag, Berlin.
•Tiedemann, K. (1983). The pig mesonephros. I. Enzyme histochemical observations on the segmentation of the nephron. Anat Embryol 137:113-123.
•Tiedemann, K. and Egerer, G. (1984). Vascularization and glomerular ultrastructure in the pig mesonephros. Cell Tissue Res 238:165-75.
•Tiedemann, K. and Wettstein, R. (1980). The mature mesonephric nephron of the rabbit embryo. I. SEM-studies. Cell Tissue Res 209:95-109.
•Tiedemann, K. and Zaar, K. (1983). The pig mesonephros. II. The proximal tubule: SEM, TEM and freeze-fracture images. Anat Embryol 168:241-52.
•Vetter, M. and Gibley, C. (1966). Morphogenesis and histochemistry of the developing mouse kidney. J Morphol 120:135–55.
•Yoshinari, T., and Fujita, T. (1981). Scanning electron microscope studies on rabbit renal glomerulus, with special reference to "podocytic membrane" of Elias and to pored domes on capillary endothelium. Arch Histol Jpn 45:99-109.

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1
 
How to Cite this Article
Pubmed Style

Sahar E. Fayez , Ahmed Sayed-Ahmed, Ismail I. Abo-Ghanema, Mohamed A. Elnasharty. Morphogenesis of Rabbit Kidney Pre-and Postnatal. AJVS. 2014; 41(1): 47-61. doi:10.5455/ajvs.154807


Web Style

Sahar E. Fayez , Ahmed Sayed-Ahmed, Ismail I. Abo-Ghanema, Mohamed A. Elnasharty. Morphogenesis of Rabbit Kidney Pre-and Postnatal. https://www.alexjvs.com/?mno=154807 [Access: April 30, 2022]. doi:10.5455/ajvs.154807


AMA (American Medical Association) Style

Sahar E. Fayez , Ahmed Sayed-Ahmed, Ismail I. Abo-Ghanema, Mohamed A. Elnasharty. Morphogenesis of Rabbit Kidney Pre-and Postnatal. AJVS. 2014; 41(1): 47-61. doi:10.5455/ajvs.154807



Vancouver/ICMJE Style

Sahar E. Fayez , Ahmed Sayed-Ahmed, Ismail I. Abo-Ghanema, Mohamed A. Elnasharty. Morphogenesis of Rabbit Kidney Pre-and Postnatal. AJVS. (2014), [cited April 30, 2022]; 41(1): 47-61. doi:10.5455/ajvs.154807



Harvard Style

Sahar E. Fayez , Ahmed Sayed-Ahmed, Ismail I. Abo-Ghanema, Mohamed A. Elnasharty (2014) Morphogenesis of Rabbit Kidney Pre-and Postnatal. AJVS, 41 (1), 47-61. doi:10.5455/ajvs.154807



Turabian Style

Sahar E. Fayez , Ahmed Sayed-Ahmed, Ismail I. Abo-Ghanema, Mohamed A. Elnasharty. 2014. Morphogenesis of Rabbit Kidney Pre-and Postnatal. Alexandria Journal of Veterinary Sciences, 41 (1), 47-61. doi:10.5455/ajvs.154807



Chicago Style

Sahar E. Fayez , Ahmed Sayed-Ahmed, Ismail I. Abo-Ghanema, Mohamed A. Elnasharty. "Morphogenesis of Rabbit Kidney Pre-and Postnatal." Alexandria Journal of Veterinary Sciences 41 (2014), 47-61. doi:10.5455/ajvs.154807



MLA (The Modern Language Association) Style

Sahar E. Fayez , Ahmed Sayed-Ahmed, Ismail I. Abo-Ghanema, Mohamed A. Elnasharty. "Morphogenesis of Rabbit Kidney Pre-and Postnatal." Alexandria Journal of Veterinary Sciences 41.1 (2014), 47-61. Print. doi:10.5455/ajvs.154807



APA (American Psychological Association) Style

Sahar E. Fayez , Ahmed Sayed-Ahmed, Ismail I. Abo-Ghanema, Mohamed A. Elnasharty (2014) Morphogenesis of Rabbit Kidney Pre-and Postnatal. Alexandria Journal of Veterinary Sciences, 41 (1), 47-61. doi:10.5455/ajvs.154807





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