E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Research (Original Article) 


Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt

Mohamed A. Y. Helal, Hamada D.H. Mahboub, Shaaban A. Hemeda, Salah S. El Ballal, Hanim S. Heikal.

Cited by (1)

Abstract
Polymerase Chain Reaction-Restriction Fragment Length Polymorphisms (PCR–RFLP) and Single Nucleotide polymorphism (SNP) techniques were used to study the association between bone morphogenetic protein receptor IB (BMPR IB) gene polymorphism with litter size trait and kids growth. Forty four Female goats were precisely selected according to their litter size and kids growth. PCR amplification of 190 bp of the BMPR-IB gene was genotyped in all goats and sequenced only in those produced the highest and lowest litter size and kids growth. Restriction analysis of PCR-RFLP using Ava II and Hind III of the BMPR-IB gene (190-bp) do not produce restriction fragments. By DNA sequencing, eight single nucleotide polymorphisms (SNP’s) at seven different positions were obtained. Furthermore, with translation of SNPs to corresponding amino acids, change of six amino acids in three female goats were obtained as the flowing, Baladi goat with high litter size, glutamic acid (E) changed to aspartic acid (P) and isoleucine (I) changed to valine (V). In high litter size, Zaraibi goat, valine (V) changed to leucine acid (L) and glutamine (Q) changed to histidine (H). In another Zaraibi Goat with high litter size valine (V) changed to leucine acid (L) and threonine (T) changed to proline (P). These findings can be used in a marker-assisted selection (MAS) for selection for high litter size trait in goats. There are negative relationships in most goats between SNPs in BMPR IB gene and relative growth gain (RGG).

Key words: Goat, BMPR- IB gene, polymorphism


 
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REFERENCES
Adu, I.F., Odeniyi, A.O. Taiwo, B.B.A.1988.Production characteristics of a herd of West African Dwarf goats at Ubiaja, Bendel State of Nigeria. In: O.B. Smith and Bosman, H.G. (Editors), Goat production in the humid tropics. pp 140-144.
Altschul, S. F., Gish, W., Miller. W., Myers, E. W.,Lipman, D. J. 1990. Basic local alignment search tool. J. Mol. Biol. 215: 403-410.Brody, S. 1945. Bioenergetics and growth. 1st Ed.Baltimore, USA, 502-507.
Cognie Y., Benoit, F., Poulin, N., Khatir, H. M. A. 1998. Effect of follicle size and of the FecB Booroola gene on oocyte function in sheep. Driancourt journal of reproduction and fertility, 112: 379-386.El-Hanafy,A.A. El-Saadani, M.A., 2009.
Fingerprinting of FecB gene in five Egyptian sheep breeds. Biotech. Anim. Husbandry, 25: 205-212.Ghaffari, M., Nejati-Javaremi, A., Rahimi, G. 2009.Detection of polymorphism in BMPR-IB gene associated with twining in Shal sheep using PCRRFLP method. Int. J. Agric. Biol. 11: 97–99.
Mulsant, P., Lecerf, F., Fabre, P., Schibler L., Monget, P., Lanneluc, I., Pisselet, C., Riquet, J., Monniaux, D., Callebaut, I., Cribiu, E., Thimonieri, J., Teyssieri, J., Bodin, L., Cognie, Y., Chitour, N., Elsen J.M. 2001. Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Merino ewes. P.N.A.S. 98: 5104–5109.
Nyamsamba, D., Takahashi, H., Nomura, K., Zagclsuren Y., Minezawa M., Amano T., 2002.Microsatellite analysis of Mongolian goat populations: high genetic variation within and low genetic differentiation between population. Proceeding of the 7th world congress on genetics applied to livestock production, August 19- 23, Montpellier, France.
Odubote, I.k., Akinokun, J.O., Ademosun, A.A., 1992. Production characteristics of West African Dwarf goats under improved management system. In: A.AO. Ayeni and H.G.Bosman (EDITORS), systems goat production. Proceedings of an international workshop held at the Obafemi Awolowo University, Ile-Ife, 6- 9 july 1992, pp. 202-207.
Ouafi, T., Babilliof, J., Lcroux, C., Martin, P., 2002. Genetic diversity of the two main Moroccan goat breeds: Phylogenetic relationships with four breeds reared in France. Small Rumin. Res. 45: 225-233. [DOI via Crossref]   
Smith, P., Hudson, N.L., Corrigan, K.A., Shaw, L., Smith, T., Phillips, D.J., McNatty, K.P.J. 1996. Effects of the Booroola gene (FecB(B)) on bodymass, testis development and hormone concentrations during fetal life. Reprod. Fertil. 2: 253–261.
Smith, P., O, W.S., Hudson, N.L., Shaw, L., Heath, D.A., Condell, L., Phillips, D.J., McNatty, K.P., 1993. Effects of the Booroola gene (FecB) on body weight, ovarian development and hormone concentrations during fetal life. J. Reprod. Fertil. 1: 41–54.
Soller M., Beckmamn J.S., 1982. Restriction fragment length polymorphism and genetic improvement. Proc. of the 2nd World Congress on Genetics Applied to Livestock Production Vol. VI, pp. 396-404. Editorial Garsi, Madrid.
Souza, C. J., MacDougall, C., Campbell, B., McNeilly, A., Baird, D.T., 2001. The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type1B (BMPR1B) gene. J. Endocrinol169, R1–6.
Souza, C.J., Campbell, B.K., McNeilly, A.S., Baird, D.T. 2003. Bone morphogenetic proteins and folliculogenesis: lessons from the Booroola mutation. Reprod. Suppl. 61, 361–370.
Van Vlaenderen, G. 1989. A study of Village level sheep and goat development. In: sheep and goat meat production in the humid tropics of West African. Animal Production and Health paper FAO, Rome, 70: 142-169.
Welsh, J., Mecldhmd, M. 1990. Fingerprinting genomes using PCR with arbitrary primers. Nucl. Acids Res., 18: 7213-7218. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
Williams, J. G. K., Kublik, A. R., Livak, K. J., Rafalski, J. A., Tingey, S.V. 1990. DNA polymorphisms amplified by arbitrary primers are useful as genetic markers. Nucl. acid Res. 18:6531-6535. [DOI via Crossref]   
Wilson, T., Wu X, Juengel, J., Ross, I., Lumsden, J., Lord, E., Dodds, K., Walling, A., McEwan, J., O’Connell, A., McNatty, K., Montgomery, G. 2001. Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells.Biol. Reprod. 64: 1225–1235.
Zhou, G.L., Jin, H.G., Liu, C., Guo, S.L., Zhu, Q.,Wu, Y.H. 2005. Association of genetic polymorphism in GH gene with milk production traits in Beijing Holstein cows. J. Biosci. 30, (5): 595-598 [DOI via Crossref]    [Pubmed]   

This Article Cited By the following articles

Associations between single nucleotide polymorphisms in multiple candidate genes and body weight in rabbits
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1
 

How to Cite this Article
Pubmed Style

Helal MAY, Mahboub HD, Hemeda SA, Ballal SSE, Heikal HS. Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt. AJVS. 2014; 41(1): 28-34. doi:10.5455/ajvs.155470


Web Style

Helal MAY, Mahboub HD, Hemeda SA, Ballal SSE, Heikal HS. Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt. http://www.alexjvs.com/?mno=158714 [Access: August 21, 2018]. doi:10.5455/ajvs.155470


AMA (American Medical Association) Style

Helal MAY, Mahboub HD, Hemeda SA, Ballal SSE, Heikal HS. Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt. AJVS. 2014; 41(1): 28-34. doi:10.5455/ajvs.155470



Vancouver/ICMJE Style

Helal MAY, Mahboub HD, Hemeda SA, Ballal SSE, Heikal HS. Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt. AJVS. (2014), [cited August 21, 2018]; 41(1): 28-34. doi:10.5455/ajvs.155470



Harvard Style

Helal, M. A. Y., Mahboub, H. D., Hemeda, S. A., Ballal, S. S. E. & Heikal, H. S. (2014) Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt. AJVS, 41 (1), 28-34. doi:10.5455/ajvs.155470



Turabian Style

Helal, Mohamed A. Y., Hamada D.H. Mahboub, Shaaban A. Hemeda, Salah S. El Ballal, and Hanim S. Heikal. 2014. Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt. Alexandria Journal of Veterinary Sciences, 41 (1), 28-34. doi:10.5455/ajvs.155470



Chicago Style

Helal, Mohamed A. Y., Hamada D.H. Mahboub, Shaaban A. Hemeda, Salah S. El Ballal, and Hanim S. Heikal. "Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt." Alexandria Journal of Veterinary Sciences 41 (2014), 28-34. doi:10.5455/ajvs.155470



MLA (The Modern Language Association) Style

Helal, Mohamed A. Y., Hamada D.H. Mahboub, Shaaban A. Hemeda, Salah S. El Ballal, and Hanim S. Heikal. "Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt." Alexandria Journal of Veterinary Sciences 41.1 (2014), 28-34. Print. doi:10.5455/ajvs.155470



APA (American Psychological Association) Style

Helal, M. A. Y., Mahboub, H. D., Hemeda, S. A., Ballal, S. S. E. & Heikal, H. S. (2014) Polymorphism of Bone Morphogenetic Protein Receptor-IB (BMPR- IB) Gene with Litter Size and Kids Growth of Some Goat Breeds in Egypt. Alexandria Journal of Veterinary Sciences, 41 (1), 28-34. doi:10.5455/ajvs.155470





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