E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Research (Original Article) 


The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken

Sherin AboSaleh, Mohamed F. Salama, El-Said El-Sherbini, Maha Z. Hassan.

Abstract
The efficacy of Nigella sativa as an ameliorative medicinal plant with anticancer and antioxidant effects has drawn the attention of many researchers. The aim of this study was to examine the potential protective effect of Nigella sativa against aflatoxin-induced liver damage in chicken. A total of 40 broiler chickens were randomly divided into four groups (G1-G4). Chicks in G1 were fed on normal ration, G2 were fed on ration supplemented with 0.3 mg AFB1/kg feed, G3 were fed on ration supplemented with 1% Nigella sativa. Finally, birds in G4 were fed on a ration supplemented with 0.3 mg AFB1/kg and 1% Nigella sativa. Birds were sacrificed at the end of the experimental period (four weeks); the serum and liver were harvested for biochemical, histological and gene expression analyses. Our results showed that Nigella sativa alleviates the toxic effects of Aflatoxins by antagonizing lipid peroxidation, oxidative stress and apoptosis by modulating the expression of antiapoptotic BCL-2 and pro-apoptotic BAX. Moreover, Nigella sativa exhibited anti-inflammatory effect as evidenced by restoring proinflammatory cytokines levels. Nigella sativa can be used as a feed additive to poultry diets to alleviate any potential aflatoxin toxicity from contaminated diets.

Key words: Aflatoxins; Broilers; Nigella sativa; Liver damage; Apoptosis


 
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How to Cite this Article
Pubmed Style

AboSaleh S, Salama MF, El-Sherbini E, Hassan MZ. The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken. AJVS. 2019; 63(2): 113-120. doi:10.5455/ajvs.73879


Web Style

AboSaleh S, Salama MF, El-Sherbini E, Hassan MZ. The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken. http://www.alexjvs.com/?mno=73879 [Access: February 09, 2020]. doi:10.5455/ajvs.73879


AMA (American Medical Association) Style

AboSaleh S, Salama MF, El-Sherbini E, Hassan MZ. The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken. AJVS. 2019; 63(2): 113-120. doi:10.5455/ajvs.73879



Vancouver/ICMJE Style

AboSaleh S, Salama MF, El-Sherbini E, Hassan MZ. The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken. AJVS. (2019), [cited February 09, 2020]; 63(2): 113-120. doi:10.5455/ajvs.73879



Harvard Style

AboSaleh, S., Salama, . M. F., El-Sherbini, . E. & Hassan, . M. Z. (2019) The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken. AJVS, 63 (2), 113-120. doi:10.5455/ajvs.73879



Turabian Style

AboSaleh, Sherin, Mohamed F. Salama, El-Said El-Sherbini, and Maha Z. Hassan. 2019. The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken. Alexandria Journal of Veterinary Sciences, 63 (2), 113-120. doi:10.5455/ajvs.73879



Chicago Style

AboSaleh, Sherin, Mohamed F. Salama, El-Said El-Sherbini, and Maha Z. Hassan. "The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken." Alexandria Journal of Veterinary Sciences 63 (2019), 113-120. doi:10.5455/ajvs.73879



MLA (The Modern Language Association) Style

AboSaleh, Sherin, Mohamed F. Salama, El-Said El-Sherbini, and Maha Z. Hassan. "The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken." Alexandria Journal of Veterinary Sciences 63.2 (2019), 113-120. Print. doi:10.5455/ajvs.73879



APA (American Psychological Association) Style

AboSaleh, S., Salama, . M. F., El-Sherbini, . E. & Hassan, . M. Z. (2019) The Possible Ameliorative Effect of Nigella Sativa on Aflatoxin-induced Liver Damage in Chicken. Alexandria Journal of Veterinary Sciences, 63 (2), 113-120. doi:10.5455/ajvs.73879





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