E-ISSN 2536-9520 | ISSN 1110-2047
 
2024, Vol: 80, Issue: 1
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Original Article 


Pattern of Antibody Response to Trypanosoma evansi Infection: A step for production of high affinity antibodies

El-Awad M. El Hassan, Omar A. Al-Jabr, Sabry M. El-Bahr.

Abstract
TThe aim of this study is to determine the pattern of immune response during Trypanosoma evansi infection as a preliminary step for production of high affinity antibodies for use in immunoassays. Antibody response to Typanosoma evansi infection in mice was monitored during a short and a long immunization protocols. Both protocols yielded immunoglobulin M (IgM) and immunoglobulin G (IgG) responses. Observed initial antibody response was of an IgM type and later replaced by an IgG response. The IgM response was similar in both immunization protocols. It first detected on day 4, reached a peak level on day 6 and declined thereafter until it disappeared on day 37-post infection. The IgG response in the short protocol was first detected on day 17-post infection, reached a peak level on day 23 and maintained a high level up to the end of the experiment on day 45 post-infection. The IgG response in the long protocol was first detected on day 10-post infection, reached a peak level on day 42 and maintained this level to the end of the experiment. The current study suggests for the first time the pattern of immune response during Trypanosoma evansi infection as a preliminary step for production of high affinity antibodies.

Key words: Trypanosoma evansi, immunization, IgM, IgG, high affinity antibodies, immunoassays.


 
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How to Cite this Article
Pubmed Style

Hassan EME, Al-Jabr OA, El-Bahr SM. Pattern of Antibody Response to Trypanosoma evansi Infection: A step for production of high affinity antibodies. AJVS. 2021; 70(1): 1-6. doi:10.5455/ajvs.87098

Web Style

Hassan EME, Al-Jabr OA, El-Bahr SM. Pattern of Antibody Response to Trypanosoma evansi Infection: A step for production of high affinity antibodies. https://www.alexjvs.com/?mno=87098 [Access: December 03, 2023]. doi:10.5455/ajvs.87098

AMA (American Medical Association) Style

Hassan EME, Al-Jabr OA, El-Bahr SM. Pattern of Antibody Response to Trypanosoma evansi Infection: A step for production of high affinity antibodies. AJVS. 2021; 70(1): 1-6. doi:10.5455/ajvs.87098


Vancouver/ICMJE Style

Hassan EME, Al-Jabr OA, El-Bahr SM. Pattern of Antibody Response to Trypanosoma evansi Infection: A step for production of high affinity antibodies. AJVS. (2021), [cited December 03, 2023]; 70(1): 1-6. doi:10.5455/ajvs.87098


Harvard Style

Hassan, E. M. E., Al-Jabr, . O. A. & El-Bahr, . S. M. (2021) Pattern of Antibody Response to Trypanosoma evansi Infection: A step for production of high affinity antibodies. AJVS, 70 (1), 1-6. doi:10.5455/ajvs.87098


Turabian Style

Hassan, El-Awad M. El, Omar A. Al-Jabr, and Sabry M. El-Bahr. 2021. Pattern of Antibody Response to Trypanosoma evansi Infection: A step for production of high affinity antibodies. Alexandria Journal of Veterinary Sciences, 70 (1), 1-6. doi:10.5455/ajvs.87098


Chicago Style

Hassan, El-Awad M. El, Omar A. Al-Jabr, and Sabry M. El-Bahr. "Pattern of Antibody Response to Trypanosoma evansi Infection: A step for production of high affinity antibodies." Alexandria Journal of Veterinary Sciences 70 (2021), 1-6. doi:10.5455/ajvs.87098


MLA (The Modern Language Association) Style

Hassan, El-Awad M. El, Omar A. Al-Jabr, and Sabry M. El-Bahr. "Pattern of Antibody Response to Trypanosoma evansi Infection: A step for production of high affinity antibodies." Alexandria Journal of Veterinary Sciences 70.1 (2021), 1-6. Print. doi:10.5455/ajvs.87098


APA (American Psychological Association) Style

Hassan, E. M. E., Al-Jabr, . O. A. & El-Bahr, . S. M. (2021) Pattern of Antibody Response to Trypanosoma evansi Infection: A step for production of high affinity antibodies. Alexandria Journal of Veterinary Sciences, 70 (1), 1-6. doi:10.5455/ajvs.87098




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    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



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