E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


Garlic Enhances Cellular Immune Response Via Increased Secretion of IFN-y- in Chickens

Adetolase A. Bakre, Omolade A. Oladele, Oluwaseun O. Esan.

Abstract
Garlic (Allium sativum), has proven to be an effective growth promoter and immunostimulant in poultry. It`s ability to enhance cellular immune response was investigated using interferon gamma assay. A total of 100-day-old chicks were divided into 4 groups of 20 each in groups A, B, C and 40 in group D which was further sub-divided into subgroups D1 and D2. Feeds served were supplemented with varying levels of garlic meal i.e. Group A- 0.125%, Group B- 0.25%, Group C -0.5%. Group D- 0% (i.e. D1 and D2). Chicks in all groups were administered Newcastle disease vaccine HB1 strain at day-old, Lasota strain at 3-week-old. At 5-week-old, they were all challenged with the Newcastle Disease Virus Komarov strain except subgroup D2. Twelve chicks were selected randomly from each group (A, B and C as well as subgroup D1), Eight chicks were selected from subgroup D2 and were all bled at 6 week-old, sera were obtained for the assessment of interferon-gamma level and data obtained were subjected to statistical analysis using Analysis of variance and Turkey multiple comparison test (Graph Pad Prism) at p<0.05.
Mean interferon-gamma concentrations showed no significant difference (p>0.05) between groups A (151.16±0.46 pg/ml), B (151.30±0.33 pg/ml) and C (152.36±0.26pg/ml) but these values were significantly higher (p<0.05) than those of subgroups D1 (142.33±1.9pg/ml) and D2 (127.13±2.2pg/ml). Also, mean concentration in subgroup D1 was significantly (p<0.05) higher than that of subgroup D2.
The study showed that Garlic has an immunomodulatory effect in commercial chickens via an increased secretion of interferon-gamma, which could be responsible for the reported improvement in vaccinal immune response and its general antibiotic activity.
Key words: Interferon-gamma, Garlic, Cockerels, Cellular Immune Response, Newcastle disease vacci

Key words: Interferon Gamma, Garlic, Cockerels, Cellular Immune Response, Newcastle Disease Vaccines.


 
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Pubmed Style

Bakre AA, Oladele OA, Esan OO. Garlic Enhances Cellular Immune Response Via Increased Secretion of IFN-y- in Chickens. AJVS. 2020; 66(2): 74-77. doi:10.5455/ajvs.96795


Web Style

Bakre AA, Oladele OA, Esan OO. Garlic Enhances Cellular Immune Response Via Increased Secretion of IFN-y- in Chickens. https://www.alexjvs.com/?mno=96795 [Access: December 16, 2023]. doi:10.5455/ajvs.96795


AMA (American Medical Association) Style

Bakre AA, Oladele OA, Esan OO. Garlic Enhances Cellular Immune Response Via Increased Secretion of IFN-y- in Chickens. AJVS. 2020; 66(2): 74-77. doi:10.5455/ajvs.96795



Vancouver/ICMJE Style

Bakre AA, Oladele OA, Esan OO. Garlic Enhances Cellular Immune Response Via Increased Secretion of IFN-y- in Chickens. AJVS. (2020), [cited December 16, 2023]; 66(2): 74-77. doi:10.5455/ajvs.96795



Harvard Style

Bakre, A. A., Oladele, . O. A. & Esan, . O. O. (2020) Garlic Enhances Cellular Immune Response Via Increased Secretion of IFN-y- in Chickens. AJVS, 66 (2), 74-77. doi:10.5455/ajvs.96795



Turabian Style

Bakre, Adetolase A., Omolade A. Oladele, and Oluwaseun O. Esan. 2020. Garlic Enhances Cellular Immune Response Via Increased Secretion of IFN-y- in Chickens. Alexandria Journal of Veterinary Sciences, 66 (2), 74-77. doi:10.5455/ajvs.96795



Chicago Style

Bakre, Adetolase A., Omolade A. Oladele, and Oluwaseun O. Esan. "Garlic Enhances Cellular Immune Response Via Increased Secretion of IFN-y- in Chickens." Alexandria Journal of Veterinary Sciences 66 (2020), 74-77. doi:10.5455/ajvs.96795



MLA (The Modern Language Association) Style

Bakre, Adetolase A., Omolade A. Oladele, and Oluwaseun O. Esan. "Garlic Enhances Cellular Immune Response Via Increased Secretion of IFN-y- in Chickens." Alexandria Journal of Veterinary Sciences 66.2 (2020), 74-77. Print. doi:10.5455/ajvs.96795



APA (American Psychological Association) Style

Bakre, A. A., Oladele, . O. A. & Esan, . O. O. (2020) Garlic Enhances Cellular Immune Response Via Increased Secretion of IFN-y- in Chickens. Alexandria Journal of Veterinary Sciences, 66 (2), 74-77. doi:10.5455/ajvs.96795





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