Impact of the Neonicotinoid Insecticide, Thiamethoxam, on Some Reproductive Parameters in Adult Male Rabbits

Ahmed R. El-Sawasany; Osama S. El Okle; Omnia I. El Euony; Ashraf M. Nazem

doi:10.5455/ajvs.245115

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Original Article
Online Published: 03 Feb 2017

AJVS. 2016; 51(2): 386-392

doi: 10.5455/ajvs.245115

Impact of the Neonicotinoid Insecticide, Thiamethoxam, on Some Reproductive Parameters in Adult Male Rabbits

Ahmed R. El-sawasany, Osama S. El Okle, Omnia I. El Euony, Ashraf M. Nazem.

Abstract
Thiamethoxam (TMX) is one of new class neonicotinoid insecticides currently available in the Egyptian pesticide markets. The current study was designed to investigate the toxic effect of TMX on reproductive system in adult male rabbits. For this purpose, sixteen adult male Chinchilla rabbits were divided into two equal groups. Animals in the first group were treated orally with TMX at dose of 250 mg/kg b.wt for 90 days. The second group was served as control. Hormonal analysis revealed that, TMX induced a significant elevation in the serum testosterone level, while the concentrations of FSH and LH hormones did not exhibit any alterations between treated and control groups. Obtained results also showed that TMX treatment did not cause significant sperm DNA fragmentation, but caused marked alteration in sperm parameters (e.g. concentration, motility and morphology). Degeneration and necrosis of the spermatogenic cells in addition to intertubular edema and vacuolations were the major observed histopathological lesions in the testis of intoxicated animals. In conclusion, administration of TMX for 90 days in male rabbits induced a noticeable adverse effect on the testicular function and structure without the impairment of gonadotropins secretion.

Key words: Gonadotropins; Rabbits; Sperm DNA; Sperm parameters; Testis; Thiamethoxam

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Pubmed Style

El-sawasany AR, Okle OSE, Euony OIE, Nazem AM. Impact of the Neonicotinoid Insecticide, Thiamethoxam, on Some Reproductive Parameters in Adult Male Rabbits. AJVS. 2016; 51(2): 386-392. doi:10.5455/ajvs.245115

Web Style

El-sawasany AR, Okle OSE, Euony OIE, Nazem AM. Impact of the Neonicotinoid Insecticide, Thiamethoxam, on Some Reproductive Parameters in Adult Male Rabbits. https://www.alexjvs.com/?mno=257651 [Access: May 04, 2025]. doi:10.5455/ajvs.245115

AMA (American Medical Association) Style

El-sawasany AR, Okle OSE, Euony OIE, Nazem AM. Impact of the Neonicotinoid Insecticide, Thiamethoxam, on Some Reproductive Parameters in Adult Male Rabbits. AJVS. 2016; 51(2): 386-392. doi:10.5455/ajvs.245115

Vancouver/ICMJE Style

El-sawasany AR, Okle OSE, Euony OIE, Nazem AM. Impact of the Neonicotinoid Insecticide, Thiamethoxam, on Some Reproductive Parameters in Adult Male Rabbits. AJVS. (2016), [cited May 04, 2025]; 51(2): 386-392. doi:10.5455/ajvs.245115

Harvard Style

El-sawasany, A. R., Okle, . O. S. E., Euony, . O. I. E. & Nazem, . A. M. (2016) Impact of the Neonicotinoid Insecticide, Thiamethoxam, on Some Reproductive Parameters in Adult Male Rabbits. AJVS, 51 (2), 386-392. doi:10.5455/ajvs.245115

Turabian Style

El-sawasany, Ahmed R., Osama S. El Okle, Omnia I. El Euony, and Ashraf M. Nazem. 2016. Impact of the Neonicotinoid Insecticide, Thiamethoxam, on Some Reproductive Parameters in Adult Male Rabbits. Alexandria Journal of Veterinary Sciences, 51 (2), 386-392. doi:10.5455/ajvs.245115

Chicago Style

El-sawasany, Ahmed R., Osama S. El Okle, Omnia I. El Euony, and Ashraf M. Nazem. "Impact of the Neonicotinoid Insecticide, Thiamethoxam, on Some Reproductive Parameters in Adult Male Rabbits." Alexandria Journal of Veterinary Sciences 51 (2016), 386-392. doi:10.5455/ajvs.245115

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APA (American Psychological Association) Style

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