Histo-Biochemical Changes and Endogenous Antioxidant Response to Testicular Reperfusion Of 72 Hours Duration in Rabbits with Testicular Torsion For 1 Hour

O.A. Makinde; G.O. David; S.A. Amid; E.O. Sogebi

doi:10.5455/ajvs.64458

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Original Article
Online Published: 10 Feb 2022

AJVS. 2022; 72(2): 64-70

doi: 10.5455/ajvs.64458

Histo-Biochemical Changes and Endogenous Antioxidant Response to Testicular Reperfusion Of 72 Hours Duration in Rabbits with Testicular Torsion For 1 Hour

O.a. Makinde, G.o. David, S.a. Amid, E.o. Sogebi.

Abstract
There is a dearth of evidence regarding detorsion as a surgical management of testicular torsion in studies of experimental testicular damage in rabbits. We investigated histopathological changes, oxidative stress and antioxidant response to testicular ischaemia-reperfusion Injury following torsion. Ten (10) New Zealand male peripubertal rabbits (Mean Age: 4.6 ± 1.2 months; Mean Weight: 4.3 ± 0.6 kg) were randomly hand-picked (with five (5) in each) into two groups-A and B, equally. Group A was the control while Group B underwent left testicular torsion for 1 hour and detorsion for surgical correction. Testicular tissue samples of the affected testicle were analysed for histopathological changes, Malondialdehyde (MDA), Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPx). Oedema and loss of interstitial spaces with coagulative necrosis, lobular segmentation and complete loss of architecture of seminiferous tubules were evident. There was a significant (P < 0.0001) decrease in SOD but a significant increase in MDA and GPx when compared to the control group. Surgical detorsion as correction for testicular torsion did not produce satisfactory outcome.

Key words: Surgical detorsion, ischaemia-reperfusion injury, oxidative stress, anti-oxidant, testicular torsion

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Pubmed Style

Makinde O, David G, Amid S, Sogebi E. Histo-Biochemical Changes and Endogenous Antioxidant Response to Testicular Reperfusion Of 72 Hours Duration in Rabbits with Testicular Torsion For 1 Hour. AJVS. 2022; 72(2): 64-70. doi:10.5455/ajvs.64458

Web Style

Makinde O, David G, Amid S, Sogebi E. Histo-Biochemical Changes and Endogenous Antioxidant Response to Testicular Reperfusion Of 72 Hours Duration in Rabbits with Testicular Torsion For 1 Hour. https://www.alexjvs.com/?mno=64458 [Access: May 03, 2025]. doi:10.5455/ajvs.64458

AMA (American Medical Association) Style

Makinde O, David G, Amid S, Sogebi E. Histo-Biochemical Changes and Endogenous Antioxidant Response to Testicular Reperfusion Of 72 Hours Duration in Rabbits with Testicular Torsion For 1 Hour. AJVS. 2022; 72(2): 64-70. doi:10.5455/ajvs.64458

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Harvard Style

Makinde, O., David, . G., Amid, . S. & Sogebi, . E. (2022) Histo-Biochemical Changes and Endogenous Antioxidant Response to Testicular Reperfusion Of 72 Hours Duration in Rabbits with Testicular Torsion For 1 Hour. AJVS, 72 (2), 64-70. doi:10.5455/ajvs.64458

Turabian Style

Makinde, O.a., G.o. David, S.a. Amid, and E.o. Sogebi. 2022. Histo-Biochemical Changes and Endogenous Antioxidant Response to Testicular Reperfusion Of 72 Hours Duration in Rabbits with Testicular Torsion For 1 Hour. Alexandria Journal of Veterinary Sciences, 72 (2), 64-70. doi:10.5455/ajvs.64458

Chicago Style

Makinde, O.a., G.o. David, S.a. Amid, and E.o. Sogebi. "Histo-Biochemical Changes and Endogenous Antioxidant Response to Testicular Reperfusion Of 72 Hours Duration in Rabbits with Testicular Torsion For 1 Hour." Alexandria Journal of Veterinary Sciences 72 (2022), 64-70. doi:10.5455/ajvs.64458

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