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Original Research (Original Article) Open Access


Effect of Dietary Vitamin C and Β-Glucan to Alleviate the Toxic Effect of Copper Sulphate in Tilapia Fish

Abeer M.S. El-Keredy, Abeer M. El-Shenway, Amany M. Diab, Gehan I.E. Ali, Walied S. Kotb.

Abstract
This study was designed to investigate the possibility of copper (Cu) to induce oxidative stress and biochemical perturbations in Nile tilapia liver, spleen, gills, kidney, intestine and muscle and the role of Vitamin C (Vit. C) and/or β-glucan in alleviating its toxic effects.Nile tilapia fish were randomly allotted into five groups of twenty-five each, group one served as control without any treatment, group two exposed to Cu (100g/liter water), group three to five exposed to Cu plus Vit. C (500 mg/Kg diet), β-glucan (100mg/Kg diet) or combination of Vit. C and β-glucan respectively. Fish exposed to copper significantly (P≤0.05) reduced final weight, total gain, weight gain%, RGR and significantly deteriorate FCR and PER compared to control, while, Vitamin C and/or β-glucan supplementation markedly improved the mentioned parameters. Copper exposure reduce blood serum total protein, triglycerides and total cholesterol concentrations, while significantly increased serum uric acid, urea and concentrations compared with control. Moreover, copper exposure increased serum GOT, GPT, CAT and SOD enzymes activitiesand significantly reduced phagocytic index and activity compared to control. Vitamin C and/or β-glucan supplementation with copper exposure maintained the previous parameters near the normal and modulated antioxidant enzymes. Also, Vit. C or β-glucan reduce Cu residue in Nile tilapia muscle. Cu exposure leading to various pathological changes in liver (necrosis and mild vacuolation), kidney (tubular vacuolation), spleen (lymphoid depletion), gills (lamella fusion), intestine (enteritis) and muscles (Zenkers necrosis), while dietary Vit.C and/or β-glucan supplementation reduce the pathological lesions induced by copper exposure.The present study could concluded thatdietary supplementation of 500 mg/Kg coated vitamin C plus 100 mg/Kg β-glucan reduced the harmful effects of Cu on Nile tilapia.

Key words: Nile tilapia Copper toxicity Vitamin C β-glucanGrowth performance Histopathological changes.


 
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Pubmed Style

El-Keredy AM, El-Shenway AM, Diab AM, Ali GI, Kotb WS. Effect of Dietary Vitamin C and Β-Glucan to Alleviate the Toxic Effect of Copper Sulphate in Tilapia Fish. AJVS. 2017; 55(1): 36-49. doi:10.5455/ajvs.276295


Web Style

El-Keredy AM, El-Shenway AM, Diab AM, Ali GI, Kotb WS. Effect of Dietary Vitamin C and Β-Glucan to Alleviate the Toxic Effect of Copper Sulphate in Tilapia Fish. http://www.alexjvs.com//?mno=276295 [Access: December 18, 2017]. doi:10.5455/ajvs.276295


AMA (American Medical Association) Style

El-Keredy AM, El-Shenway AM, Diab AM, Ali GI, Kotb WS. Effect of Dietary Vitamin C and Β-Glucan to Alleviate the Toxic Effect of Copper Sulphate in Tilapia Fish. AJVS. 2017; 55(1): 36-49. doi:10.5455/ajvs.276295



Vancouver/ICMJE Style

El-Keredy AM, El-Shenway AM, Diab AM, Ali GI, Kotb WS. Effect of Dietary Vitamin C and Β-Glucan to Alleviate the Toxic Effect of Copper Sulphate in Tilapia Fish. AJVS. (2017), [cited December 18, 2017]; 55(1): 36-49. doi:10.5455/ajvs.276295



Harvard Style

El-Keredy, A. M., El-Shenway, A. M., Diab, A. M., Ali, G. I. & Kotb, W. S. (2017) Effect of Dietary Vitamin C and Β-Glucan to Alleviate the Toxic Effect of Copper Sulphate in Tilapia Fish. AJVS, 55 (1), 36-49. doi:10.5455/ajvs.276295



Turabian Style

El-Keredy, Abeer M.S., Abeer M. El-Shenway, Amany M. Diab, Gehan I.E. Ali, and Walied S. Kotb. 2017. Effect of Dietary Vitamin C and Β-Glucan to Alleviate the Toxic Effect of Copper Sulphate in Tilapia Fish. Alexandria Journal of Veterinary Sciences, 55 (1), 36-49. doi:10.5455/ajvs.276295



Chicago Style

El-Keredy, Abeer M.S., Abeer M. El-Shenway, Amany M. Diab, Gehan I.E. Ali, and Walied S. Kotb. "Effect of Dietary Vitamin C and Β-Glucan to Alleviate the Toxic Effect of Copper Sulphate in Tilapia Fish." Alexandria Journal of Veterinary Sciences 55 (2017), 36-49. doi:10.5455/ajvs.276295



MLA (The Modern Language Association) Style

El-Keredy, Abeer M.S., Abeer M. El-Shenway, Amany M. Diab, Gehan I.E. Ali, and Walied S. Kotb. "Effect of Dietary Vitamin C and Β-Glucan to Alleviate the Toxic Effect of Copper Sulphate in Tilapia Fish." Alexandria Journal of Veterinary Sciences 55.1 (2017), 36-49. Print. doi:10.5455/ajvs.276295



APA (American Psychological Association) Style

El-Keredy, A. M., El-Shenway, A. M., Diab, A. M., Ali, G. I. & Kotb, W. S. (2017) Effect of Dietary Vitamin C and Β-Glucan to Alleviate the Toxic Effect of Copper Sulphate in Tilapia Fish. Alexandria Journal of Veterinary Sciences, 55 (1), 36-49. doi:10.5455/ajvs.276295





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