E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Research (Original Article) 


Curcumin A Potential Antagonist Against Paracetamol Induced Nephrotoxicity in Rats

Manal R. Ibrahim, Nabil M. Taha, Abd El-Wahab Mandour, Mohamed A. Lebda, Aml E. Hashem.

Abstract
Paracetamol can cause a life threating renal damage and there is no specific treatment for it. Therefore, the current study aims to investigate the nepheroprotective effect of curcumin against paracetamol nephrotoxicity in rats through determination of kidney function parameters, minerals concentration, kidney lipid peroxidation and antioxidants. To achieve this aim, seventy adult male albino rats were divided into equal seven groups as following, Group I served as control,Group II (corn oil treated group), Group III (curcumin200 mg/kg b.wt/orally), Group IV (Curcumin 400 mg/kg b.wt/orally), Group V served as positive control (Paracetamol 500 mg/kg b.wt/orally), Group VI (Curcumin 200 mg/kg b.wt and paracetamol 500 mg/kg b.wt/orally), and Group VII (Curcumin 400 mg/kg b.w and paracetamol 500 mg/kg b.w/orally). At the end of experiment (after 30 days), blood and tissue samples were collected for biochemical, and histopathological analysis.

Key words: Renal toxicity, Curcumin, Paracetamol,Rats.


 
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How to Cite this Article
Pubmed Style

Ibrahim MR, Taha NM, Mandour AE, Lebda MA, Hashem AE. Curcumin A Potential Antagonist Against Paracetamol Induced Nephrotoxicity in Rats. AJVS. 2019; 62(2): 37-44. doi:10.5455/ajvs.58645


Web Style

Ibrahim MR, Taha NM, Mandour AE, Lebda MA, Hashem AE. Curcumin A Potential Antagonist Against Paracetamol Induced Nephrotoxicity in Rats. http://www.alexjvs.com/?mno=58645 [Access: February 09, 2020]. doi:10.5455/ajvs.58645


AMA (American Medical Association) Style

Ibrahim MR, Taha NM, Mandour AE, Lebda MA, Hashem AE. Curcumin A Potential Antagonist Against Paracetamol Induced Nephrotoxicity in Rats. AJVS. 2019; 62(2): 37-44. doi:10.5455/ajvs.58645



Vancouver/ICMJE Style

Ibrahim MR, Taha NM, Mandour AE, Lebda MA, Hashem AE. Curcumin A Potential Antagonist Against Paracetamol Induced Nephrotoxicity in Rats. AJVS. (2019), [cited February 09, 2020]; 62(2): 37-44. doi:10.5455/ajvs.58645



Harvard Style

Ibrahim, M. R., Taha, . N. M., Mandour, . A. E., Lebda, . M. A. & Hashem, . A. E. (2019) Curcumin A Potential Antagonist Against Paracetamol Induced Nephrotoxicity in Rats. AJVS, 62 (2), 37-44. doi:10.5455/ajvs.58645



Turabian Style

Ibrahim, Manal R., Nabil M. Taha, Abd El-Wahab Mandour, Mohamed A. Lebda, and Aml E. Hashem. 2019. Curcumin A Potential Antagonist Against Paracetamol Induced Nephrotoxicity in Rats. Alexandria Journal of Veterinary Sciences, 62 (2), 37-44. doi:10.5455/ajvs.58645



Chicago Style

Ibrahim, Manal R., Nabil M. Taha, Abd El-Wahab Mandour, Mohamed A. Lebda, and Aml E. Hashem. "Curcumin A Potential Antagonist Against Paracetamol Induced Nephrotoxicity in Rats." Alexandria Journal of Veterinary Sciences 62 (2019), 37-44. doi:10.5455/ajvs.58645



MLA (The Modern Language Association) Style

Ibrahim, Manal R., Nabil M. Taha, Abd El-Wahab Mandour, Mohamed A. Lebda, and Aml E. Hashem. "Curcumin A Potential Antagonist Against Paracetamol Induced Nephrotoxicity in Rats." Alexandria Journal of Veterinary Sciences 62.2 (2019), 37-44. Print. doi:10.5455/ajvs.58645



APA (American Psychological Association) Style

Ibrahim, M. R., Taha, . N. M., Mandour, . A. E., Lebda, . M. A. & Hashem, . A. E. (2019) Curcumin A Potential Antagonist Against Paracetamol Induced Nephrotoxicity in Rats. Alexandria Journal of Veterinary Sciences, 62 (2), 37-44. doi:10.5455/ajvs.58645





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