E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Research (Original Article) 


Potential Protective Effect of Curcumin on Paracetamol Model of Liver Injury in Rats

Rania A. Sedky, Nabil M. Taha, Abd El-Wahab Mandour, Mohamed A. Lebda, Aml E. Hashem.

Abstract
Abstract
Objective
The objective of the this study is to investigate the protective effect of curcumin on paracetamol induced hepatotoxicity in rats through determination of, serum protein concentration, ammonia, bilirubin, liver enzymes activities, liver lipid peroxidation and antioxidants. The study was carried on 70 male rats weighing 140 10 divided into equal 7 groups as following: GI: control, GII: control corn, GIII: curcumin (200mg/kgb.wt/gavage), GIV: curcumin (400mg/kgb.wt/gavage), GV: paracetamol (500mg/kgb.wt/gavage), GVI: Curcumin (200mg/kgb.wt/gavage) + paracetamol (500mg/kgb.wt/gavage) and GVII: curcumin (400mg/kgb.wt/ gavage)+ paracetamol (500mg/kgb.wt/ gavage). After 30 days, blood was collected for biochemical examination.
Results:
Paracetamol at dose (500 mg/kg b.wt) caused marked liver damage as there was pronounced increase in bilirubin, ammonia and MDA levels along with marked elevation in liver enzyme activities while levels of serum proteins, GSH and Catalase activity markedly decreased. Interestingly, curcumin was able to ameliorate hepatic deterioration caused by paracetamol via restoring depleted glutathione, rebalanced antioxidants and improved damage as curcumin (200 mg/ kg b.wt) successfully decreased degree of hepatic vacuolation with best improvent via curcumin (400 mg/ kg b.wt).
Conclusion:
Curcumin showed protective effect on paracetamol induced hepatotoxicity as it successfully improved the altered hepatic parameters and through its powerful antioxidant properties.

Key words: Keywords: Hepatotoxicity, paracetamol, curcumin, antioxidant.


 
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How to Cite this Article
Pubmed Style

Sedky RA, Taha NM, Mandour AE, Lebda MA, Hashem AE. Potential Protective Effect of Curcumin on Paracetamol Model of Liver Injury in Rats. AJVS. 2019; 63(1): 77-84. doi:10.5455/ajvs.63350


Web Style

Sedky RA, Taha NM, Mandour AE, Lebda MA, Hashem AE. Potential Protective Effect of Curcumin on Paracetamol Model of Liver Injury in Rats. http://www.alexjvs.com/?mno=63350 [Access: February 08, 2020]. doi:10.5455/ajvs.63350


AMA (American Medical Association) Style

Sedky RA, Taha NM, Mandour AE, Lebda MA, Hashem AE. Potential Protective Effect of Curcumin on Paracetamol Model of Liver Injury in Rats. AJVS. 2019; 63(1): 77-84. doi:10.5455/ajvs.63350



Vancouver/ICMJE Style

Sedky RA, Taha NM, Mandour AE, Lebda MA, Hashem AE. Potential Protective Effect of Curcumin on Paracetamol Model of Liver Injury in Rats. AJVS. (2019), [cited February 08, 2020]; 63(1): 77-84. doi:10.5455/ajvs.63350



Harvard Style

Sedky, R. A., Taha, . N. M., Mandour, . A. E., Lebda, . M. A. & Hashem, . A. E. (2019) Potential Protective Effect of Curcumin on Paracetamol Model of Liver Injury in Rats. AJVS, 63 (1), 77-84. doi:10.5455/ajvs.63350



Turabian Style

Sedky, Rania A., Nabil M. Taha, Abd El-Wahab Mandour, Mohamed A. Lebda, and Aml E. Hashem. 2019. Potential Protective Effect of Curcumin on Paracetamol Model of Liver Injury in Rats. Alexandria Journal of Veterinary Sciences, 63 (1), 77-84. doi:10.5455/ajvs.63350



Chicago Style

Sedky, Rania A., Nabil M. Taha, Abd El-Wahab Mandour, Mohamed A. Lebda, and Aml E. Hashem. "Potential Protective Effect of Curcumin on Paracetamol Model of Liver Injury in Rats." Alexandria Journal of Veterinary Sciences 63 (2019), 77-84. doi:10.5455/ajvs.63350



MLA (The Modern Language Association) Style

Sedky, Rania A., Nabil M. Taha, Abd El-Wahab Mandour, Mohamed A. Lebda, and Aml E. Hashem. "Potential Protective Effect of Curcumin on Paracetamol Model of Liver Injury in Rats." Alexandria Journal of Veterinary Sciences 63.1 (2019), 77-84. Print. doi:10.5455/ajvs.63350



APA (American Psychological Association) Style

Sedky, R. A., Taha, . N. M., Mandour, . A. E., Lebda, . M. A. & Hashem, . A. E. (2019) Potential Protective Effect of Curcumin on Paracetamol Model of Liver Injury in Rats. Alexandria Journal of Veterinary Sciences, 63 (1), 77-84. doi:10.5455/ajvs.63350





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