E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Research (Original Article) 


Anti-Mullerian Hormone Gene Expression and Serum Protein Concentration in Females Suffered from Diabetes Mellitus: An Animal Study

Sanaa Hafez, Mohammed El-Adl, El-Said El-Sherbini.

Abstract
This study aimed to evaluate the effect of diabetes on fertility on diabetic women especially. Sixty adult female patients aged (18 – 40) years are divided equally into three groups; G1; control healthy group, G2; type one diabetic women, G3; non fertile women. Blood samples of all individuals were analyzed for measurement of glucose, estradiol, progestrone, anti-müllerian hormone (AMH), Follicle stimulating hormone (FSH), Luteinizing hormone (LH), superoxide dismutase (SOD) and nitric oxide (NO), serum insulin and glycated hemoglobin (HbA1c) showed a significant increase in diabetic fertile group. Also plasma level of FSH, LH and SOD activity were significantly lowered in diabetic infertile group than healthy group and diabetic fertile group. NO was higher in diabetic fertile group. In AMH mRNA expression in ovarian tissues, 40 adult female Sprague-Dawley rats were divided equally into four groups; G1; normal rats, G2; diabetic 30 days group rat, G3; diabetic 45 days group rat, G4; diabetic 60 days group rat. the expression of AMH in ovaries was significantly increased in diabetic rats at day 30 compared to healthy rats and significantly decreased at days 45 and 60 compared to healthy rats. In conclusion, diabetes mellitus can affect the health status and fertility markers in females that was also observed in expression of AMH in ovarian tissues in rats

Key words: Diabetic Mellitus, AMH, SOD, NO


 
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How to Cite this Article
Pubmed Style

Hafez S, El-Adl M, El-Sherbini E. Anti-Mullerian Hormone Gene Expression and Serum Protein Concentration in Females Suffered from Diabetes Mellitus: An Animal Study. AJVS. 2020; 64(2): 1-8. doi:10.5455/ajvs.79649


Web Style

Hafez S, El-Adl M, El-Sherbini E. Anti-Mullerian Hormone Gene Expression and Serum Protein Concentration in Females Suffered from Diabetes Mellitus: An Animal Study. http://www.alexjvs.com/?mno=79649 [Access: March 15, 2020]. doi:10.5455/ajvs.79649


AMA (American Medical Association) Style

Hafez S, El-Adl M, El-Sherbini E. Anti-Mullerian Hormone Gene Expression and Serum Protein Concentration in Females Suffered from Diabetes Mellitus: An Animal Study. AJVS. 2020; 64(2): 1-8. doi:10.5455/ajvs.79649



Vancouver/ICMJE Style

Hafez S, El-Adl M, El-Sherbini E. Anti-Mullerian Hormone Gene Expression and Serum Protein Concentration in Females Suffered from Diabetes Mellitus: An Animal Study. AJVS. (2020), [cited March 15, 2020]; 64(2): 1-8. doi:10.5455/ajvs.79649



Harvard Style

Hafez, S., El-Adl, . M. & El-Sherbini, . E. (2020) Anti-Mullerian Hormone Gene Expression and Serum Protein Concentration in Females Suffered from Diabetes Mellitus: An Animal Study. AJVS, 64 (2), 1-8. doi:10.5455/ajvs.79649



Turabian Style

Hafez, Sanaa, Mohammed El-Adl, and El-Said El-Sherbini. 2020. Anti-Mullerian Hormone Gene Expression and Serum Protein Concentration in Females Suffered from Diabetes Mellitus: An Animal Study. Alexandria Journal of Veterinary Sciences, 64 (2), 1-8. doi:10.5455/ajvs.79649



Chicago Style

Hafez, Sanaa, Mohammed El-Adl, and El-Said El-Sherbini. "Anti-Mullerian Hormone Gene Expression and Serum Protein Concentration in Females Suffered from Diabetes Mellitus: An Animal Study." Alexandria Journal of Veterinary Sciences 64 (2020), 1-8. doi:10.5455/ajvs.79649



MLA (The Modern Language Association) Style

Hafez, Sanaa, Mohammed El-Adl, and El-Said El-Sherbini. "Anti-Mullerian Hormone Gene Expression and Serum Protein Concentration in Females Suffered from Diabetes Mellitus: An Animal Study." Alexandria Journal of Veterinary Sciences 64.2 (2020), 1-8. Print. doi:10.5455/ajvs.79649



APA (American Psychological Association) Style

Hafez, S., El-Adl, . M. & El-Sherbini, . E. (2020) Anti-Mullerian Hormone Gene Expression and Serum Protein Concentration in Females Suffered from Diabetes Mellitus: An Animal Study. Alexandria Journal of Veterinary Sciences, 64 (2), 1-8. doi:10.5455/ajvs.79649





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