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Original Research (Original Article) Open Access


Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus

Afrah F. Salama, Ehab M. Tousson, Wafaa M. Ibrahim.

Abstract
Normal brain development requires the presence of thyroid hormones (TH). The present study aimed to declare the effect of hyperthyroidism on oxidative stress parameters in brain tissues (cortex, hypothalamus and hippocampus) and the role of folic acid supplementation in treatment. Thirty adult rats were divided into 5 groups (Group 1, Control; Group 2, Folic acid; Group 3, Hyperthyroid; Group 4, Co-treated hyperthyroid with folic acid; Group 5, Post treated hyperthyroid with folic acid). The current results showed a significant increase in the concentrations of T3 & T4 in hyperthyroid rats when compared with control group. In contrast, TSH showed a significant decrease in hyperthyroid rats when compared with the control group. Calcium was significantly increased in hyperthyroid group when compared with control group. Catalase and MDA were increased, while total protein in brain tissues was decreased in hyperthyroid rats (G3) when compared with control group. Total thiol in brain tissues showed a significant decrease in hyperthyroid group when compared with control group. Treatment with folic acid showed enhancement in oxidative stress parameters in post treated group more than co treated group.

Key words: Hyperthyroid, Oxidative stress, Folic acid, Brain rat tissues.


 
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How to Cite this Article
Pubmed Style

Salama AF, Tousson EM, Ibrahim WM. Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus. AJVS. 2017; 55(1): 210-216. doi:10.5455/ajvs.273835


Web Style

Salama AF, Tousson EM, Ibrahim WM. Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus. http://www.alexjvs.com//?mno=273835 [Access: December 18, 2017]. doi:10.5455/ajvs.273835


AMA (American Medical Association) Style

Salama AF, Tousson EM, Ibrahim WM. Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus. AJVS. 2017; 55(1): 210-216. doi:10.5455/ajvs.273835



Vancouver/ICMJE Style

Salama AF, Tousson EM, Ibrahim WM. Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus. AJVS. (2017), [cited December 18, 2017]; 55(1): 210-216. doi:10.5455/ajvs.273835



Harvard Style

Salama, A. F., Tousson, E. M. & Ibrahim, W. M. (2017) Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus. AJVS, 55 (1), 210-216. doi:10.5455/ajvs.273835



Turabian Style

Salama, Afrah F., Ehab M. Tousson, and Wafaa M. Ibrahim. 2017. Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus. Alexandria Journal of Veterinary Sciences, 55 (1), 210-216. doi:10.5455/ajvs.273835



Chicago Style

Salama, Afrah F., Ehab M. Tousson, and Wafaa M. Ibrahim. "Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus." Alexandria Journal of Veterinary Sciences 55 (2017), 210-216. doi:10.5455/ajvs.273835



MLA (The Modern Language Association) Style

Salama, Afrah F., Ehab M. Tousson, and Wafaa M. Ibrahim. "Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus." Alexandria Journal of Veterinary Sciences 55.1 (2017), 210-216. Print. doi:10.5455/ajvs.273835



APA (American Psychological Association) Style

Salama, A. F., Tousson, E. M. & Ibrahim, W. M. (2017) Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus. Alexandria Journal of Veterinary Sciences, 55 (1), 210-216. doi:10.5455/ajvs.273835





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