E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


Spatiotemporal Localization Patterns of Different Lectins in Developing Rat Kidney Postnatally

Sahar F. Mahmoud and Ahmed M. Rashwan.

Abstract
Our study was designed to determine the spatiotemporal pattern of different lectins in developing rat kidneys postnatally, which was unprecedented before. We used immunohistochemistry to examine the localization of three different lectins, Concanavalin (Con A), Wheat germ agglutinin (WGA), and Peanut agglutinin (PNA), in rat kidneys of both sexes at neonatal day 1 and postnatal 1, 2, and 8 weeks. The intensity of the Con A lectin decreased with age, from intense at birth to moderate in the proximal convoluted tubules (PCT) and absent in the distal convoluted tubules (DCT) by 8 weeks. Renal corpuscles showed intense reactions to Con A in immature glomeruli at birth and intense reactivity in podocytes at 8 weeks of age in rats. Con A was intense in collecting tubules (CT) and collecting ducts (CD) of all ages. The intensity of the WGA lectin increased with age, from no reaction at birth to moderate reactions in PCT and DCT at 8 weeks. WGA was intense in immature glomeruli at birth, but only in podocytes at 8 weeks. The CT and CD showed mild to moderate reactions to WGA in all ages of rat kidneys. The PNA lectin in PCT decreased in intensity with age, from a moderate reaction at birth to no reaction at 2 and 8 weeks. The PNA lectin in DCT increased in intensity with age, from a moderate reaction at birth to an intense reaction at 8 weeks. The PNA in the renal corpuscle decreased in intensity with age, from a moderate reaction in immature glomeruli at birth to no reaction at other ages. The CT and CD showed an intense reaction to PNA in all ages of rat kidneys. We conclude that there were differences in the lectin distribution and intensity between developing and adult rat kidneys, and this variation may be related to the function of each lectin.

Key words: Rat; Lectins;Con A; WGA; PNA; Kidney


 
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Pubmed Style

Sahar F. Mahmoud and Ahmed M. Rashwan. Spatiotemporal Localization Patterns of Different Lectins in Developing Rat Kidney Postnatally. AJVS. 2022; 75(2): 6-19. doi:10.5455/ajvs.129020


Web Style

Sahar F. Mahmoud and Ahmed M. Rashwan. Spatiotemporal Localization Patterns of Different Lectins in Developing Rat Kidney Postnatally. https://www.alexjvs.com/?mno=129020 [Access: January 29, 2023]. doi:10.5455/ajvs.129020


AMA (American Medical Association) Style

Sahar F. Mahmoud and Ahmed M. Rashwan. Spatiotemporal Localization Patterns of Different Lectins in Developing Rat Kidney Postnatally. AJVS. 2022; 75(2): 6-19. doi:10.5455/ajvs.129020



Vancouver/ICMJE Style

Sahar F. Mahmoud and Ahmed M. Rashwan. Spatiotemporal Localization Patterns of Different Lectins in Developing Rat Kidney Postnatally. AJVS. (2022), [cited January 29, 2023]; 75(2): 6-19. doi:10.5455/ajvs.129020



Harvard Style

Sahar F. Mahmoud and Ahmed M. Rashwan (2022) Spatiotemporal Localization Patterns of Different Lectins in Developing Rat Kidney Postnatally. AJVS, 75 (2), 6-19. doi:10.5455/ajvs.129020



Turabian Style

Sahar F. Mahmoud and Ahmed M. Rashwan. 2022. Spatiotemporal Localization Patterns of Different Lectins in Developing Rat Kidney Postnatally. Alexandria Journal of Veterinary Sciences, 75 (2), 6-19. doi:10.5455/ajvs.129020



Chicago Style

Sahar F. Mahmoud and Ahmed M. Rashwan. "Spatiotemporal Localization Patterns of Different Lectins in Developing Rat Kidney Postnatally." Alexandria Journal of Veterinary Sciences 75 (2022), 6-19. doi:10.5455/ajvs.129020



MLA (The Modern Language Association) Style

Sahar F. Mahmoud and Ahmed M. Rashwan. "Spatiotemporal Localization Patterns of Different Lectins in Developing Rat Kidney Postnatally." Alexandria Journal of Veterinary Sciences 75.2 (2022), 6-19. Print. doi:10.5455/ajvs.129020



APA (American Psychological Association) Style

Sahar F. Mahmoud and Ahmed M. Rashwan (2022) Spatiotemporal Localization Patterns of Different Lectins in Developing Rat Kidney Postnatally. Alexandria Journal of Veterinary Sciences, 75 (2), 6-19. doi:10.5455/ajvs.129020





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