E-ISSN 2536-9520 | ISSN 1110-2047
 
2024, Vol: 80, Issue: 1
80 / 1Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Original Article 


Zinc Oxide Nanoparticles Alleviated Hepatic Oxidative Stress Induced By Cadmium Chloride Toxicity In Rats

Samar M. Elshamaa, Nabil M. Taha, Mohamed A. Lebda, Aml E. Hashem, Mohamed S. Elfeky.

Abstract
Cadmium (Cd) is a ubiquitous contaminant of dietary products and natural surroundings and has been listed as one of the Top 20 Hazardous Substances by ATSDR. Cd is a cumulative toxicant. Once absorbed, it is principally deposited in liver and kidney. Zinc oxide nanoparticles (ZnONPs) are widely incorporated as a food additive in animal diets. In order to optimize the beneficial effects of ZnONPs and minimize any resultant environmental pollution, ZnONPs significantly attenuated cadmium chloride (CdCl2)-induced hepatic toxicity. This work aimed to investigate the protective effect of ZnONPs against hepatic toxicity induced by CdCl2. Twenty male adult rats weighing from 150 ± 20 g were randomly allocated into 4 groups (5rats/each); control, CdCl2, ZnONPs and CdCl2 and ZnONPs treated groups. Results revealed that treatment with ZnONPs showed reduction of oxidative stress caused by CdCl2. However, ZnONPs attenuated previous toxicity through improvement of liver enzymes including LDH, ALP, AST, ALT, antioxidant markers as CAT, GSH, MDA, NRF2 and MT. CdCl2 and ZnONPs treated group is the best group to overcome Cd-induced hepatotoxicity. It could be concluded that co-administration of ZnONPs with CdCl2 has a positive cooperative effect on liver and ZnONPs significantly attenuate CdCl2-induced damage in the liver through the reduction of oxidative stress.

Key words: Zinc oxide nanoparticles, Cadmium chloride, Hepatotoxicity.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Samar M. Elshamaa
Articles by Nabil M. Taha
Articles by Mohamed A. Lebda
Articles by Aml E. Hashem
Articles by Mohamed S. Elfeky
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Elshamaa SM, Taha NM, Lebda MA, Hashem AE, Elfeky MS. Zinc Oxide Nanoparticles Alleviated Hepatic Oxidative Stress Induced By Cadmium Chloride Toxicity In Rats. AJVS. 2022; 73(1): 1-7. doi:10.5455/ajvs.140591

Web Style

Elshamaa SM, Taha NM, Lebda MA, Hashem AE, Elfeky MS. Zinc Oxide Nanoparticles Alleviated Hepatic Oxidative Stress Induced By Cadmium Chloride Toxicity In Rats. https://www.alexjvs.com/?mno=140591 [Access: December 03, 2023]. doi:10.5455/ajvs.140591

AMA (American Medical Association) Style

Elshamaa SM, Taha NM, Lebda MA, Hashem AE, Elfeky MS. Zinc Oxide Nanoparticles Alleviated Hepatic Oxidative Stress Induced By Cadmium Chloride Toxicity In Rats. AJVS. 2022; 73(1): 1-7. doi:10.5455/ajvs.140591


Vancouver/ICMJE Style

Elshamaa SM, Taha NM, Lebda MA, Hashem AE, Elfeky MS. Zinc Oxide Nanoparticles Alleviated Hepatic Oxidative Stress Induced By Cadmium Chloride Toxicity In Rats. AJVS. (2022), [cited December 03, 2023]; 73(1): 1-7. doi:10.5455/ajvs.140591


Harvard Style

Elshamaa, S. M., Taha, . N. M., Lebda, . M. A., Hashem, . A. E. & Elfeky, . M. S. (2022) Zinc Oxide Nanoparticles Alleviated Hepatic Oxidative Stress Induced By Cadmium Chloride Toxicity In Rats. AJVS, 73 (1), 1-7. doi:10.5455/ajvs.140591


Turabian Style

Elshamaa, Samar M., Nabil M. Taha, Mohamed A. Lebda, Aml E. Hashem, and Mohamed S. Elfeky. 2022. Zinc Oxide Nanoparticles Alleviated Hepatic Oxidative Stress Induced By Cadmium Chloride Toxicity In Rats. Alexandria Journal of Veterinary Sciences, 73 (1), 1-7. doi:10.5455/ajvs.140591


Chicago Style

Elshamaa, Samar M., Nabil M. Taha, Mohamed A. Lebda, Aml E. Hashem, and Mohamed S. Elfeky. "Zinc Oxide Nanoparticles Alleviated Hepatic Oxidative Stress Induced By Cadmium Chloride Toxicity In Rats." Alexandria Journal of Veterinary Sciences 73 (2022), 1-7. doi:10.5455/ajvs.140591


MLA (The Modern Language Association) Style

Elshamaa, Samar M., Nabil M. Taha, Mohamed A. Lebda, Aml E. Hashem, and Mohamed S. Elfeky. "Zinc Oxide Nanoparticles Alleviated Hepatic Oxidative Stress Induced By Cadmium Chloride Toxicity In Rats." Alexandria Journal of Veterinary Sciences 73.1 (2022), 1-7. Print. doi:10.5455/ajvs.140591


APA (American Psychological Association) Style

Elshamaa, S. M., Taha, . N. M., Lebda, . M. A., Hashem, . A. E. & Elfeky, . M. S. (2022) Zinc Oxide Nanoparticles Alleviated Hepatic Oxidative Stress Induced By Cadmium Chloride Toxicity In Rats. Alexandria Journal of Veterinary Sciences, 73 (1), 1-7. doi:10.5455/ajvs.140591




Most Viewed Articles
Most Accessed Articles

  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract » doi: 10.5455/ajvs.154650

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract » doi: 10.5455/ajvs.45443

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

    •
    Most Downloaded
    Top Downloaded Articles

  • Comparative Study of Cellular and Humoral Immune Response to BHV-1 Vaccines in Cattle and Buffalo Calves
    Fayrouz S. Naim; Samy A. Khalil and Helmy A. Torky
    AJVS. 2016; 51(2): 367-373
    » Abstract

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

  • Effect of Excess Fluoride on Reproductive Potentials in Farm Animals (Ovine)
    Ghada H. Abdel-Rahman, Hanaa A. El-Hallawany, Dohreig RA.
    AJVS. 2018; 57(2): 41-57
    » Abstract » doi: 10.5455/ajvs.296364

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Using of Polypropylene Mesh for Hernioplasty in Calves
    Mostafa M. kassam, Mahmoud H. Elkammer, Ahmed S. Korittum, Ali A. Abdel-Wahed
    AJVS. 2014; 40(1): 112-117
    » Abstract » doi: 10.5455/ajvs.47290

    •
    Most Cited Articles
    Most Cited Articles

    About Alexandria Journal of Veterinary Sciences

    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



    For best results, please use Internet Explorer or Google Chrome.

    Contact Information

    Faculty of Veterinary Medicine, Alexandria University
    Edfina, Behaira, Egypt.
    PO.Box: 22758
    Telefax: +20 45 2963526
    POLICIES & JOURNAL LINKS
    Author Login
    Reviewer Login
    About Publisher
    Advertising Policy
    Author's Rights and Obligations
    Conflict of Interest Policy
    Copyright Information
    Digital Archiving & Preservation Policies
    Editorial Policies
    Peer Review Policy
    Editorial & Peer Review Process
    License Information
    Open Access Policy
    Plagiarism Policy
    Privacy Policy
    Protection of Research Participants (Statement On Human And Animal Rights)
    Publication Ethics and Publication Malpractice Statement
    Corrections, Retractions & Expressions of Concern
    Self-Archiving Policies
    Statement of Informed Consent
    Terms of Use