E-ISSN 2536-9520 | ISSN 1110-2047
 
2024, Vol: 83
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Original Article
Online Published: 20 Mar 2023
 


Investigation of Thiol-Disulphide Homeostasis, Total Oxidant-Antioxidant and Ischaemia-Modified Albumin Levels in Dogs with Babesiosis

Mustafa Tarhan, Yeter Deger, Bekir Oguz, Ugur Ozdek.


Abstract
This study was designed to reveal the diagnostic efficiency of total antioxidant capacity (TAC), total oxidant capacity (TOC), oxidative stress index (OSI), thiol/disulphide homeostasis (TDH), albumin (ALB) and ischaemia-modified albumin (IMA) parameters in the assessment of oxidative stress in dogs with babesiosis. While the babesiosis group consisted of a total of 7 dogs with clinical and parasitological (ELISA) diagnoses of babesiosis, the control group consisted of 7 healthy dogs. Blood samples were taken from both groups. While the levels of TAC, TOC and ALB in the blood serums of the groups were measured using a commercial kit, the levels of total thiol (TT), native thiol (NT) and IMA were measured using the method. The OSI and disulphide (Ds) levels were calculated using the formula. When compared with the control group, TAC and ALB levels significantly decreased, whereas the levels of TOC and OSI elevated in the babesiosis group (p<0.05). No difference was found between the groups in terms of NT, TT, Ds, and IMA levels and the ratios of NT/TT, Ds/TT, and Ds/NT (p˃0.05). A negative significant correlation was found between TAC and OSI and between Ds/NT and NT, TT and NT/TT (p<0.05; p<0.001, respectively). A significant positive correlation was found between NT and TT and NT/TT and between TT and NT/TT (p<0.001). The areas under the ROC curve of the variables TAC, TOC, OSI and ALB were found to be 0.918, 0.796, 0.980 and 1, respectively. The results showed that TAC, TOC, OSI and ALB performed diagnostically in the assessment of elevated oxidative stress in dogs with babesiosis.

Key words: Dog, Babesiosis, TOC, TAC, OSI, TDH, IMA, ALB


 
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How to Cite this Article
Pubmed Style

Tarhan M, Deger Y, Oguz B, Ozdek U. Investigation of Thiol-Disulphide Homeostasis, Total Oxidant-Antioxidant and Ischaemia-Modified Albumin Levels in Dogs with Babesiosis. AJVS. 2023; 77(1): 21-29. doi:10.5455/ajvs.145761

Web Style

Tarhan M, Deger Y, Oguz B, Ozdek U. Investigation of Thiol-Disulphide Homeostasis, Total Oxidant-Antioxidant and Ischaemia-Modified Albumin Levels in Dogs with Babesiosis. https://www.alexjvs.com/?mno=145761 [Access: December 02, 2024]. doi:10.5455/ajvs.145761

AMA (American Medical Association) Style

Tarhan M, Deger Y, Oguz B, Ozdek U. Investigation of Thiol-Disulphide Homeostasis, Total Oxidant-Antioxidant and Ischaemia-Modified Albumin Levels in Dogs with Babesiosis. AJVS. 2023; 77(1): 21-29. doi:10.5455/ajvs.145761


Vancouver/ICMJE Style

Tarhan M, Deger Y, Oguz B, Ozdek U. Investigation of Thiol-Disulphide Homeostasis, Total Oxidant-Antioxidant and Ischaemia-Modified Albumin Levels in Dogs with Babesiosis. AJVS. (2023), [cited December 02, 2024]; 77(1): 21-29. doi:10.5455/ajvs.145761


Harvard Style

Tarhan, M., Deger, . Y., Oguz, . B. & Ozdek, . U. (2023) Investigation of Thiol-Disulphide Homeostasis, Total Oxidant-Antioxidant and Ischaemia-Modified Albumin Levels in Dogs with Babesiosis. AJVS, 77 (1), 21-29. doi:10.5455/ajvs.145761


Turabian Style

Tarhan, Mustafa, Yeter Deger, Bekir Oguz, and Ugur Ozdek. 2023. Investigation of Thiol-Disulphide Homeostasis, Total Oxidant-Antioxidant and Ischaemia-Modified Albumin Levels in Dogs with Babesiosis. Alexandria Journal of Veterinary Sciences, 77 (1), 21-29. doi:10.5455/ajvs.145761


Chicago Style

Tarhan, Mustafa, Yeter Deger, Bekir Oguz, and Ugur Ozdek. "Investigation of Thiol-Disulphide Homeostasis, Total Oxidant-Antioxidant and Ischaemia-Modified Albumin Levels in Dogs with Babesiosis." Alexandria Journal of Veterinary Sciences 77 (2023), 21-29. doi:10.5455/ajvs.145761


MLA (The Modern Language Association) Style

Tarhan, Mustafa, Yeter Deger, Bekir Oguz, and Ugur Ozdek. "Investigation of Thiol-Disulphide Homeostasis, Total Oxidant-Antioxidant and Ischaemia-Modified Albumin Levels in Dogs with Babesiosis." Alexandria Journal of Veterinary Sciences 77.1 (2023), 21-29. Print. doi:10.5455/ajvs.145761


APA (American Psychological Association) Style

Tarhan, M., Deger, . Y., Oguz, . B. & Ozdek, . U. (2023) Investigation of Thiol-Disulphide Homeostasis, Total Oxidant-Antioxidant and Ischaemia-Modified Albumin Levels in Dogs with Babesiosis. Alexandria Journal of Veterinary Sciences, 77 (1), 21-29. doi:10.5455/ajvs.145761




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    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



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