E-ISSN 2536-9520 | ISSN 1110-2047
 
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Original Article
Online Published: 08 Oct 2014
 


Genetic Polymorphism in Growth hormone receptor Gene and its Relationship with Growth Trait in Pure and Hybrid Rabbit Breeds

Ferial M. Sahwan, Ahmed I. El-Sheik, Mohamed M. Sharaf, Abeer F. El-Nahas.


Abstract
Single Nucleotide polymorphism (SNP) techniques were used for association between exon 1 of growth hormone receptor (GHR1) gene and marketing body weights in three rabbit breeds; New Zealand White rabbit breed (pure breed), V-line (Hybrid breeds from New Zealand and California rabbit), and Alexandria breed (Hybrid from V-Line and black Egyptian Baladi rabbit). DNA from blood samples of each kid of the three rabbit breeds were extracted to amplify 263-bp of the gene encoding GHR1. The purified PCR products were sequenced in those had the highest and lowest body weight in each breed. Sixteen new SNPs were detected in GHR1 gene in New Zeland rabbits. In V-line rabbits, three SNPs were detected. Also two SNPs were found in Alex. breed. All these SNPs were related to high body weight as they were reported in higher body weights in the three breeds, and were non synonymous, which led to amino acids substitution. Restriction analysis of PCR product using MSP1 do not produce restriction fragments. Statistically, the results indicated that there were significant correlation between growth performance and GHR1 gene polymorphisms. The results were effective in selection for rabbits that have high growth performance (marker assisted selection). Also, the analysis of this study confirmed that GHR1 gene could be a candidate gene for application in marker assisted selection (MAS) in rabbits.

Key words: Rabbits, GHR gene, polymorphism, marketing weight


 
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How to Cite this Article
Pubmed Style

Ferial M. Sahwan, Ahmed I. El-Sheik, Mohamed M. Sharaf, Abeer F. El-Nahas. Genetic Polymorphism in Growth hormone receptor Gene and its Relationship with Growth Trait in Pure and Hybrid Rabbit Breeds. AJVS. 2014; 43(1): 45-51. doi:10.5455/ajvs.165197

Web Style

Ferial M. Sahwan, Ahmed I. El-Sheik, Mohamed M. Sharaf, Abeer F. El-Nahas. Genetic Polymorphism in Growth hormone receptor Gene and its Relationship with Growth Trait in Pure and Hybrid Rabbit Breeds. https://www.alexjvs.com/?mno=165197 [Access: December 02, 2024]. doi:10.5455/ajvs.165197

AMA (American Medical Association) Style

Ferial M. Sahwan, Ahmed I. El-Sheik, Mohamed M. Sharaf, Abeer F. El-Nahas. Genetic Polymorphism in Growth hormone receptor Gene and its Relationship with Growth Trait in Pure and Hybrid Rabbit Breeds. AJVS. 2014; 43(1): 45-51. doi:10.5455/ajvs.165197


Vancouver/ICMJE Style

Ferial M. Sahwan, Ahmed I. El-Sheik, Mohamed M. Sharaf, Abeer F. El-Nahas. Genetic Polymorphism in Growth hormone receptor Gene and its Relationship with Growth Trait in Pure and Hybrid Rabbit Breeds. AJVS. (2014), [cited December 02, 2024]; 43(1): 45-51. doi:10.5455/ajvs.165197


Harvard Style

Ferial M. Sahwan, Ahmed I. El-Sheik, Mohamed M. Sharaf, Abeer F. El-Nahas (2014) Genetic Polymorphism in Growth hormone receptor Gene and its Relationship with Growth Trait in Pure and Hybrid Rabbit Breeds. AJVS, 43 (1), 45-51. doi:10.5455/ajvs.165197


Turabian Style

Ferial M. Sahwan, Ahmed I. El-Sheik, Mohamed M. Sharaf, Abeer F. El-Nahas. 2014. Genetic Polymorphism in Growth hormone receptor Gene and its Relationship with Growth Trait in Pure and Hybrid Rabbit Breeds. Alexandria Journal of Veterinary Sciences, 43 (1), 45-51. doi:10.5455/ajvs.165197


Chicago Style

Ferial M. Sahwan, Ahmed I. El-Sheik, Mohamed M. Sharaf, Abeer F. El-Nahas. "Genetic Polymorphism in Growth hormone receptor Gene and its Relationship with Growth Trait in Pure and Hybrid Rabbit Breeds." Alexandria Journal of Veterinary Sciences 43 (2014), 45-51. doi:10.5455/ajvs.165197


MLA (The Modern Language Association) Style

Ferial M. Sahwan, Ahmed I. El-Sheik, Mohamed M. Sharaf, Abeer F. El-Nahas. "Genetic Polymorphism in Growth hormone receptor Gene and its Relationship with Growth Trait in Pure and Hybrid Rabbit Breeds." Alexandria Journal of Veterinary Sciences 43.1 (2014), 45-51. Print. doi:10.5455/ajvs.165197


APA (American Psychological Association) Style

Ferial M. Sahwan, Ahmed I. El-Sheik, Mohamed M. Sharaf, Abeer F. El-Nahas (2014) Genetic Polymorphism in Growth hormone receptor Gene and its Relationship with Growth Trait in Pure and Hybrid Rabbit Breeds. Alexandria Journal of Veterinary Sciences, 43 (1), 45-51. doi:10.5455/ajvs.165197




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    About Alexandria Journal of Veterinary Sciences

    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



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    Egypt.

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