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2025, Vol: 84
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Original Article
Online Published: 14 Mar 2025
 


Antidiabetic effects of ethanolic extract of cocos nucifera husk in streptozotocin-induced diabetic rats.

Adeniran Adekunle Sanmi, Ibukun Oluwafunmilayo Akinbola, Emmanuel Bukoye Oyewo, Ifeoluwa Abraham Akinbola, Mofoluwaso Funmilayo Adisa.


Abstract
The management of blood glucose level is critical in the treatment of diabetes and this had been offered by α-amylase and α-glucosidase inhibitors. Hence, the antidiabetic effects of ethanolic extract of Cocos nucifera husk (CoCoH) was investigated by evaluating the ameliorating effect on glucose concentration as well as its inihibitory properties towards carbohydrate hydrolyzing enzymes. Type 2 diabetes was induced into 100 female Wistar rats by the intraperitoneal administration of streptozotocin (40mg/kg) following 8 weeks of high fat diet (HFD) feeding. The ethanolic extract of CoCoH at doses of 125, 250, 500, 750 and 1000mg/kg body weight was administered to the diabetic-induced rats at a single dose per day for 21 days. The ethanolic extract inhibited the activities of α-amylase and α-glucosidase in vitro and in vivo. The results also revealed that the extract reduced (p≤0.05) blood glucose levels similar to that of the reference drug, metformin. Consequently, the extract showed inhibitory activity on glucose-6-phosphatase at all concentrations except at 1000mg/kg. Hence, inhibitions of α-amylase, α-glucosidase and glucose-6-phosphatase activities may be some of the mechanisms by which ethanolic extract of CoCoH exerts antihyperglycemic activity and thus indicates that CoCoH can be considered for the management of type 2 diabetes.

Key words: Diabetes, Disaccharidases, glucose, hyperglycemia, obesity


 
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How to Cite this Article
Pubmed Style

Sanmi AA, Akinbola IO, Oyewo EB, Akinbola IA, Adisa MF. Antidiabetic effects of ethanolic extract of cocos nucifera husk in streptozotocin-induced diabetic rats.. AJVS. Online First: 14 Mar, 2025. doi:10.5455/ajvs.230062

Web Style

Sanmi AA, Akinbola IO, Oyewo EB, Akinbola IA, Adisa MF. Antidiabetic effects of ethanolic extract of cocos nucifera husk in streptozotocin-induced diabetic rats.. https://www.alexjvs.com/?mno=230062 [Access: March 26, 2025]. doi:10.5455/ajvs.230062

AMA (American Medical Association) Style

Sanmi AA, Akinbola IO, Oyewo EB, Akinbola IA, Adisa MF. Antidiabetic effects of ethanolic extract of cocos nucifera husk in streptozotocin-induced diabetic rats.. AJVS. Online First: 14 Mar, 2025. doi:10.5455/ajvs.230062


Vancouver/ICMJE Style

Sanmi AA, Akinbola IO, Oyewo EB, Akinbola IA, Adisa MF. Antidiabetic effects of ethanolic extract of cocos nucifera husk in streptozotocin-induced diabetic rats.. AJVS, [cited March 26, 2025]; Online First: 14 Mar, 2025. doi:10.5455/ajvs.230062


Harvard Style

Sanmi, A. A., Akinbola, . I. O., Oyewo, . E. B., Akinbola, . I. A. & Adisa, . M. F. (0) Antidiabetic effects of ethanolic extract of cocos nucifera husk in streptozotocin-induced diabetic rats.. AJVS, Online First: 14 Mar, 2025. doi:10.5455/ajvs.230062


Turabian Style

Sanmi, Adeniran Adekunle, Ibukun Oluwafunmilayo Akinbola, Emmanuel Bukoye Oyewo, Ifeoluwa Abraham Akinbola, and Mofoluwaso Funmilayo Adisa. 0. Antidiabetic effects of ethanolic extract of cocos nucifera husk in streptozotocin-induced diabetic rats.. Alexandria Journal of Veterinary Sciences, Online First: 14 Mar, 2025. doi:10.5455/ajvs.230062


Chicago Style

Sanmi, Adeniran Adekunle, Ibukun Oluwafunmilayo Akinbola, Emmanuel Bukoye Oyewo, Ifeoluwa Abraham Akinbola, and Mofoluwaso Funmilayo Adisa. "Antidiabetic effects of ethanolic extract of cocos nucifera husk in streptozotocin-induced diabetic rats.." Alexandria Journal of Veterinary Sciences Online First: 14 Mar, 2025. doi:10.5455/ajvs.230062


MLA (The Modern Language Association) Style

Sanmi, Adeniran Adekunle, Ibukun Oluwafunmilayo Akinbola, Emmanuel Bukoye Oyewo, Ifeoluwa Abraham Akinbola, and Mofoluwaso Funmilayo Adisa. "Antidiabetic effects of ethanolic extract of cocos nucifera husk in streptozotocin-induced diabetic rats.." Alexandria Journal of Veterinary Sciences Online First: 14 Mar, 2025. Web. 26 Mar 2025 doi:10.5455/ajvs.230062


APA (American Psychological Association) Style

Sanmi, A. A., Akinbola, . I. O., Oyewo, . E. B., Akinbola, . I. A. & Adisa, . M. F. (0) Antidiabetic effects of ethanolic extract of cocos nucifera husk in streptozotocin-induced diabetic rats.. Alexandria Journal of Veterinary Sciences, Online First: 14 Mar, 2025. doi:10.5455/ajvs.230062




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