E-ISSN 2536-9520 | ISSN 1110-2047
 
2024, Vol: 83
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Original Article
Online Published: 29 May 2016
 


Complement Component C3 is a Critical Point in Aged Choroidal Vessels in the Complement Factor H knock Out Model of Retinal Degeneration.

Asmaa S. Aboelnour, Mohamed A. Elnasharty, Ahmed S. Ahmed and Glen Jeffery.


Abstract
Deposition of extra cellular material is a feature of retinal ageing resulting in reduced outer retinal perfusion that can be associated with disease. This has been documented for Bruch’s membrane (BM) and is elevated in mice that are complement factor H knock outs (Cfh-/-) and proposed as a model for macular degeneration. Here we ask if aged deposition occurs to the outer retinal blood supply before transmission across BM in 12 month old C57Bl and Cfh-/- mice and if differences exist at this level between these mice. We show arterial deposition of age related proteins complement component C3 with immunostaining and Western blot. Results showed deposition of C3 in all internal lamina of choroid blood vessels and three fragments were revealed from western blot which decrease significantly in Cfh-/- mice choroid.

Key words: Choroid, Complement component C3, Immunostaining, Western blot


 
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How to Cite this Article
Pubmed Style

Asmaa S. Aboelnour, Mohamed A. Elnasharty, Ahmed S. Ahmed and Glen Jeffery. Complement Component C3 is a Critical Point in Aged Choroidal Vessels in the Complement Factor H knock Out Model of Retinal Degeneration. . AJVS. 2016; 49(2): 184-188. doi:10.5455/ajvs.225699

Web Style

Asmaa S. Aboelnour, Mohamed A. Elnasharty, Ahmed S. Ahmed and Glen Jeffery. Complement Component C3 is a Critical Point in Aged Choroidal Vessels in the Complement Factor H knock Out Model of Retinal Degeneration. . https://www.alexjvs.com/?mno=230583 [Access: September 12, 2024]. doi:10.5455/ajvs.225699

AMA (American Medical Association) Style

Asmaa S. Aboelnour, Mohamed A. Elnasharty, Ahmed S. Ahmed and Glen Jeffery. Complement Component C3 is a Critical Point in Aged Choroidal Vessels in the Complement Factor H knock Out Model of Retinal Degeneration. . AJVS. 2016; 49(2): 184-188. doi:10.5455/ajvs.225699


Vancouver/ICMJE Style

Asmaa S. Aboelnour, Mohamed A. Elnasharty, Ahmed S. Ahmed and Glen Jeffery. Complement Component C3 is a Critical Point in Aged Choroidal Vessels in the Complement Factor H knock Out Model of Retinal Degeneration. . AJVS. (2016), [cited September 12, 2024]; 49(2): 184-188. doi:10.5455/ajvs.225699


Harvard Style

Asmaa S. Aboelnour, Mohamed A. Elnasharty, Ahmed S. Ahmed and Glen Jeffery (2016) Complement Component C3 is a Critical Point in Aged Choroidal Vessels in the Complement Factor H knock Out Model of Retinal Degeneration. . AJVS, 49 (2), 184-188. doi:10.5455/ajvs.225699


Turabian Style

Asmaa S. Aboelnour, Mohamed A. Elnasharty, Ahmed S. Ahmed and Glen Jeffery. 2016. Complement Component C3 is a Critical Point in Aged Choroidal Vessels in the Complement Factor H knock Out Model of Retinal Degeneration. . Alexandria Journal of Veterinary Sciences, 49 (2), 184-188. doi:10.5455/ajvs.225699


Chicago Style

Asmaa S. Aboelnour, Mohamed A. Elnasharty, Ahmed S. Ahmed and Glen Jeffery. "Complement Component C3 is a Critical Point in Aged Choroidal Vessels in the Complement Factor H knock Out Model of Retinal Degeneration. ." Alexandria Journal of Veterinary Sciences 49 (2016), 184-188. doi:10.5455/ajvs.225699


MLA (The Modern Language Association) Style

Asmaa S. Aboelnour, Mohamed A. Elnasharty, Ahmed S. Ahmed and Glen Jeffery. "Complement Component C3 is a Critical Point in Aged Choroidal Vessels in the Complement Factor H knock Out Model of Retinal Degeneration. ." Alexandria Journal of Veterinary Sciences 49.2 (2016), 184-188. Print. doi:10.5455/ajvs.225699


APA (American Psychological Association) Style

Asmaa S. Aboelnour, Mohamed A. Elnasharty, Ahmed S. Ahmed and Glen Jeffery (2016) Complement Component C3 is a Critical Point in Aged Choroidal Vessels in the Complement Factor H knock Out Model of Retinal Degeneration. . Alexandria Journal of Veterinary Sciences, 49 (2), 184-188. doi:10.5455/ajvs.225699




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    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



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