Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis

Mohammed Elbeskawy; Mohamed El-Adl; Mohamed Hamed; Mayar Ali and Moustafa Al-Araby

doi:10.5455/ajvs.245366

2025, Vol: 86

86Current Volume Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

« Previous Article

Original Article
Online Published: 30 Nov 2016

AJVS. 2016; 51(1): 198-206

doi: 10.5455/ajvs.245366

Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis

Mohammed Elbeskawy, Mohamed El-adl, Mohamed Hamed, Mayar Ali And Moustafa Al-araby.

Abstract
Ovine coenurosis is a disease condition characterized by nervous manifestations that is associated with severe economic losses for sheep farm owners. This study was conducted to investigate the expression of myelin basic protein (MBP) gene in various regions of the brain in affected animals at different ages. We also studied the prevalence of coenurosis in Dakhlia governorate with parasitological and electron microscopic examinations to evaluate the severity of infestation. Ourresults revealed that MBP expression was down regulated in all brain regions at different ages. A hundred-fold reduction in MBP expression wasobserved in the cerebral cortex and a 500-fold decrease was observed in sheep older than one year. However, no differences were observed in MBP expression at different ages or different brain regions. Moreover, the highest prevalence of ovine coenurosis in Dakhlia governorate was in Belqas city in sheep aged more than 12 months with the highest incidence in the cerebral cortex. Electron microscopic examination revealed demyelination in nerve tracts with the existence of gitter cells indicating the severity of coenurosis. From these results, we concluded that MBP is down-regulated in sheep affected with coenurosis and could serve as a novel marker for ovine coenurosis and other demyelinating diseases in sheep.

Key words: Ovine, Coenurosis, parasitic diseases, myelin basic protein

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Mohammed Elbeskawy Articles by Mohamed El-Adl Articles by Mohamed Hamed Articles by Mayar Ali and Moustafa Al-Araby
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Elbeskawy M, El-adl M, Hamed M, Al-araby MAAM. Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis. AJVS. 2016; 51(1): 198-206. doi:10.5455/ajvs.245366

Web Style

Elbeskawy M, El-adl M, Hamed M, Al-araby MAAM. Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis. https://www.alexjvs.com/?mno=250850 [Access: May 04, 2025]. doi:10.5455/ajvs.245366

AMA (American Medical Association) Style

Elbeskawy M, El-adl M, Hamed M, Al-araby MAAM. Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis. AJVS. 2016; 51(1): 198-206. doi:10.5455/ajvs.245366

Vancouver/ICMJE Style

Elbeskawy M, El-adl M, Hamed M, Al-araby MAAM. Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis. AJVS. (2016), [cited May 04, 2025]; 51(1): 198-206. doi:10.5455/ajvs.245366

Harvard Style

Elbeskawy, M., El-adl, . M., Hamed, . M. & Al-araby, . M. A. A. M. (2016) Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis. AJVS, 51 (1), 198-206. doi:10.5455/ajvs.245366

Turabian Style

Elbeskawy, Mohammed, Mohamed El-adl, Mohamed Hamed, and Mayar Ali And Moustafa Al-araby. 2016. Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis. Alexandria Journal of Veterinary Sciences, 51 (1), 198-206. doi:10.5455/ajvs.245366

Chicago Style

Elbeskawy, Mohammed, Mohamed El-adl, Mohamed Hamed, and Mayar Ali And Moustafa Al-araby. "Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis." Alexandria Journal of Veterinary Sciences 51 (2016), 198-206. doi:10.5455/ajvs.245366

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Elbeskawy, M., El-adl, . M., Hamed, . M. & Al-araby, . M. A. A. M. (2016) Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis. Alexandria Journal of Veterinary Sciences, 51 (1), 198-206. doi:10.5455/ajvs.245366

About Alexandria Journal of Veterinary Sciences

Contact Information

How to cite this article