E-ISSN 2536-9520 | ISSN 1110-2047
 
2024, Vol: 83
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Original Article 


Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats

Asmaa M. Khamis, Samah S. Oda, Asmaa F. Khafaga, Mohamed A. Hashem.


Abstract
The toxicity of hydroxyurea (HU), a treatment for specific neoplasms, sickle-cell disease, polycythemia vera and thrombocytosis was assessed in rats. Forty rats were divided equally into four groups. The first group was kept as control and received only purified water, the second group (HU250) orally administered hydroxyurea 250 mg/kg b.wt/day, the third group (HU500) administered hydroxyurea 500 mg/kg b.wt/day and the fourth group (HU750) administered hydroxyurea 750 mg/kg b.wt/day. The treatment was continued for 20 days. The evaluated parameters were assessed after 10 and 20 days of the experiment. Results revealed decrease in body weight in all treated groups. In addition, decreased circulating leukocytes, erythrocytes and platelets with decreased bone marrow cellularity were evident in all treated groups with different degree of severity. Moreover, aplastic anemia associated with marked severe hypocellularity of bone marrow was detected in HU500 and HU750 groups on the second period of the experiment. It could be concluded that hydroxyurea administration induced hematopoietic and bone marrow toxicity in rats.

Key words: hydroxyurea, bone marrow, aplastic anemia, hematology.


 
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How to Cite this Article
Pubmed Style

Asmaa M. Khamis, Samah S. Oda, Asmaa F. Khafaga, Mohamed A. Hashem. Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats. AJVS. 2017; 55(2): 77-82. doi:10.5455/ajvs.267052

Web Style

Asmaa M. Khamis, Samah S. Oda, Asmaa F. Khafaga, Mohamed A. Hashem. Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats. https://www.alexjvs.com/?mno=267052 [Access: December 01, 2024]. doi:10.5455/ajvs.267052

AMA (American Medical Association) Style

Asmaa M. Khamis, Samah S. Oda, Asmaa F. Khafaga, Mohamed A. Hashem. Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats. AJVS. 2017; 55(2): 77-82. doi:10.5455/ajvs.267052


Vancouver/ICMJE Style

Asmaa M. Khamis, Samah S. Oda, Asmaa F. Khafaga, Mohamed A. Hashem. Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats. AJVS. (2017), [cited December 01, 2024]; 55(2): 77-82. doi:10.5455/ajvs.267052


Harvard Style

Asmaa M. Khamis, Samah S. Oda, Asmaa F. Khafaga, Mohamed A. Hashem (2017) Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats. AJVS, 55 (2), 77-82. doi:10.5455/ajvs.267052


Turabian Style

Asmaa M. Khamis, Samah S. Oda, Asmaa F. Khafaga, Mohamed A. Hashem. 2017. Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats. Alexandria Journal of Veterinary Sciences, 55 (2), 77-82. doi:10.5455/ajvs.267052


Chicago Style

Asmaa M. Khamis, Samah S. Oda, Asmaa F. Khafaga, Mohamed A. Hashem. "Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats." Alexandria Journal of Veterinary Sciences 55 (2017), 77-82. doi:10.5455/ajvs.267052


MLA (The Modern Language Association) Style

Asmaa M. Khamis, Samah S. Oda, Asmaa F. Khafaga, Mohamed A. Hashem. "Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats." Alexandria Journal of Veterinary Sciences 55.2 (2017), 77-82. Print. doi:10.5455/ajvs.267052


APA (American Psychological Association) Style

Asmaa M. Khamis, Samah S. Oda, Asmaa F. Khafaga, Mohamed A. Hashem (2017) Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats. Alexandria Journal of Veterinary Sciences, 55 (2), 77-82. doi:10.5455/ajvs.267052




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    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



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