E-ISSN 2536-9520 | ISSN 1110-2047
 
2025, Vol: 85
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Original Article 


Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus

Afrah F. Salama, Ehab M. Tousson, Wafaa M. Ibrahim.


Abstract
Normal brain development requires the presence of thyroid hormones (TH). The present study aimed to declare the effect of hyperthyroidism on oxidative stress parameters in brain tissues (cortex, hypothalamus and hippocampus) and the role of folic acid supplementation in treatment. Thirty adult rats were divided into 5 groups (Group 1, Control; Group 2, Folic acid; Group 3, Hyperthyroid; Group 4, Co-treated hyperthyroid with folic acid; Group 5, Post treated hyperthyroid with folic acid). The current results showed a significant increase in the concentrations of T3 & T4 in hyperthyroid rats when compared with control group. In contrast, TSH showed a significant decrease in hyperthyroid rats when compared with the control group. Calcium was significantly increased in hyperthyroid group when compared with control group. Catalase and MDA were increased, while total protein in brain tissues was decreased in hyperthyroid rats (G3) when compared with control group. Total thiol in brain tissues showed a significant decrease in hyperthyroid group when compared with control group. Treatment with folic acid showed enhancement in oxidative stress parameters in post treated group more than co treated group.

Key words: Hyperthyroid, Oxidative stress, Folic acid, Brain rat tissues.


 
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How to Cite this Article
Pubmed Style

Salama AF, Tousson EM, Ibrahim WM. Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus. AJVS. 2017; 55(1): 210-216. doi:10.5455/ajvs.273835

Web Style

Salama AF, Tousson EM, Ibrahim WM. Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus. https://www.alexjvs.com/?mno=273835 [Access: March 27, 2025]. doi:10.5455/ajvs.273835

AMA (American Medical Association) Style

Salama AF, Tousson EM, Ibrahim WM. Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus. AJVS. 2017; 55(1): 210-216. doi:10.5455/ajvs.273835


Vancouver/ICMJE Style

Salama AF, Tousson EM, Ibrahim WM. Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus. AJVS. (2017), [cited March 27, 2025]; 55(1): 210-216. doi:10.5455/ajvs.273835


Harvard Style

Salama, A. F., Tousson, . E. M. & Ibrahim, . W. M. (2017) Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus. AJVS, 55 (1), 210-216. doi:10.5455/ajvs.273835


Turabian Style

Salama, Afrah F., Ehab M. Tousson, and Wafaa M. Ibrahim. 2017. Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus. Alexandria Journal of Veterinary Sciences, 55 (1), 210-216. doi:10.5455/ajvs.273835


Chicago Style

Salama, Afrah F., Ehab M. Tousson, and Wafaa M. Ibrahim. "Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus." Alexandria Journal of Veterinary Sciences 55 (2017), 210-216. doi:10.5455/ajvs.273835


MLA (The Modern Language Association) Style

Salama, Afrah F., Ehab M. Tousson, and Wafaa M. Ibrahim. "Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus." Alexandria Journal of Veterinary Sciences 55.1 (2017), 210-216. Print. doi:10.5455/ajvs.273835


APA (American Psychological Association) Style

Salama, A. F., Tousson, . E. M. & Ibrahim, . W. M. (2017) Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus. Alexandria Journal of Veterinary Sciences, 55 (1), 210-216. doi:10.5455/ajvs.273835




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    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



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