E-ISSN 2536-9520 | ISSN 1110-2047
 
2024, Vol: 83
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Original Article
Online Published: 16 Jan 2021
 


Effect of Constant Rate Infusion of Tramadol-Xylazine and Pentazocine Xylazine on Acute Pain Response in Xylazine-Pentobarbitone Anaesthetized Dogs Undergoing Digital Amputation

Ijeoma R. Udegbunam, Frank U. Ogbodo, Chukwudum A. Onuba, Nnamdi H. Okereke, Toochukwu H. Ezeobialu, Sunday O. Udegbunam.


Abstract
The study evaluated the effect of constant rate infusion of tramadol-xylazine and pentazocine-xylazine on pain in dogs undergoing digital amputation. Twelve mongrel used for the study were randomly assigned to four groups (n=3). Group 1 received loading dose (LD) Xylazine (1mg/kg IV) and Pentobarbitone sodium (Na) (30mg/kg IV) [LD-XP] prior to digital amputation (DA).Group 2 received LD-XP andXylazine (1mg/kg/hr) by constant rate infusion (CRI IV) prior to DA. Group 3 received LD Xylazine (1mg/kg IV), Pentobarbitone Na (30mg/kg IV), CRI Xylazine (1mg/kg/hr) and Tramadol (1mg/kg/hr) prior to DA. Group 4 received LD-XP, CRI Xylazine (1mg/kg/hr) and CRI Pentazocine (1mg/kg/hr) prior to DA. Results of the pain score evaluation showed that at 1, 3, 6 and 24 hours post-surgery (PS), group 4 had the lowest (p<0.05) pain score followed by group 3. Group 4 animals had a significantly (p<0.05) higher heart rate and pulse rate values at 3 and 120 hours. The respiratory rate of group 4 was significantly higher (p<0.05) when compared with the other groups at 3 and 24 hours. It was concluded that CRI pentazocine-xylazine provided better analgesia in the dog DA model.

Key words: pain, tramadol, analgesia, multi-modal, pentazocine, xylazine


 
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How to Cite this Article
Pubmed Style

Udegbunam IR, Ogbodo FU, Onuba CA, Okereke NH, Ezeobialu TH, Udegbunam SO. Effect of Constant Rate Infusion of Tramadol-Xylazine and Pentazocine Xylazine on Acute Pain Response in Xylazine-Pentobarbitone Anaesthetized Dogs Undergoing Digital Amputation. AJVS. 2021; 70(1): 140-150. doi:10.5455/ajvs.28363

Web Style

Udegbunam IR, Ogbodo FU, Onuba CA, Okereke NH, Ezeobialu TH, Udegbunam SO. Effect of Constant Rate Infusion of Tramadol-Xylazine and Pentazocine Xylazine on Acute Pain Response in Xylazine-Pentobarbitone Anaesthetized Dogs Undergoing Digital Amputation. https://www.alexjvs.com/?mno=28363 [Access: September 13, 2024]. doi:10.5455/ajvs.28363

AMA (American Medical Association) Style

Udegbunam IR, Ogbodo FU, Onuba CA, Okereke NH, Ezeobialu TH, Udegbunam SO. Effect of Constant Rate Infusion of Tramadol-Xylazine and Pentazocine Xylazine on Acute Pain Response in Xylazine-Pentobarbitone Anaesthetized Dogs Undergoing Digital Amputation. AJVS. 2021; 70(1): 140-150. doi:10.5455/ajvs.28363


Vancouver/ICMJE Style

Udegbunam IR, Ogbodo FU, Onuba CA, Okereke NH, Ezeobialu TH, Udegbunam SO. Effect of Constant Rate Infusion of Tramadol-Xylazine and Pentazocine Xylazine on Acute Pain Response in Xylazine-Pentobarbitone Anaesthetized Dogs Undergoing Digital Amputation. AJVS. (2021), [cited September 13, 2024]; 70(1): 140-150. doi:10.5455/ajvs.28363


Harvard Style

Udegbunam, I. R., Ogbodo, . F. U., Onuba, . C. A., Okereke, . N. H., Ezeobialu, . T. H. & Udegbunam, . S. O. (2021) Effect of Constant Rate Infusion of Tramadol-Xylazine and Pentazocine Xylazine on Acute Pain Response in Xylazine-Pentobarbitone Anaesthetized Dogs Undergoing Digital Amputation. AJVS, 70 (1), 140-150. doi:10.5455/ajvs.28363


Turabian Style

Udegbunam, Ijeoma R., Frank U. Ogbodo, Chukwudum A. Onuba, Nnamdi H. Okereke, Toochukwu H. Ezeobialu, and Sunday O. Udegbunam. 2021. Effect of Constant Rate Infusion of Tramadol-Xylazine and Pentazocine Xylazine on Acute Pain Response in Xylazine-Pentobarbitone Anaesthetized Dogs Undergoing Digital Amputation. Alexandria Journal of Veterinary Sciences, 70 (1), 140-150. doi:10.5455/ajvs.28363


Chicago Style

Udegbunam, Ijeoma R., Frank U. Ogbodo, Chukwudum A. Onuba, Nnamdi H. Okereke, Toochukwu H. Ezeobialu, and Sunday O. Udegbunam. "Effect of Constant Rate Infusion of Tramadol-Xylazine and Pentazocine Xylazine on Acute Pain Response in Xylazine-Pentobarbitone Anaesthetized Dogs Undergoing Digital Amputation." Alexandria Journal of Veterinary Sciences 70 (2021), 140-150. doi:10.5455/ajvs.28363


MLA (The Modern Language Association) Style

Udegbunam, Ijeoma R., Frank U. Ogbodo, Chukwudum A. Onuba, Nnamdi H. Okereke, Toochukwu H. Ezeobialu, and Sunday O. Udegbunam. "Effect of Constant Rate Infusion of Tramadol-Xylazine and Pentazocine Xylazine on Acute Pain Response in Xylazine-Pentobarbitone Anaesthetized Dogs Undergoing Digital Amputation." Alexandria Journal of Veterinary Sciences 70.1 (2021), 140-150. Print. doi:10.5455/ajvs.28363


APA (American Psychological Association) Style

Udegbunam, I. R., Ogbodo, . F. U., Onuba, . C. A., Okereke, . N. H., Ezeobialu, . T. H. & Udegbunam, . S. O. (2021) Effect of Constant Rate Infusion of Tramadol-Xylazine and Pentazocine Xylazine on Acute Pain Response in Xylazine-Pentobarbitone Anaesthetized Dogs Undergoing Digital Amputation. Alexandria Journal of Veterinary Sciences, 70 (1), 140-150. doi:10.5455/ajvs.28363




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