Abstract
Camel pasteurellosis is a bacterial disease affecting respiratory system of camels caused by Pasteurella species. In Egypt, there are no recommended vaccination programs of camel against pasteurellosis. Therefore, evaluation of the efficacy of a polyvalent pasteurella vaccine (Pneumobac® vaccine) in camels is the main target of this research focusing the attention on its immunological and biochemical patterns. The humeral immune responses in two different camel groups (vaccinated and control) were evaluated by indirect haemagglutination test (IHA) and Passive Mouse Protection Test. The biochemical profiles of different camel groups were estimated. In addition to, the assessment of lipid peroxidation and Matrix MetaloProteinase enzymes (MMP2 and MMP9) activity of camels under this vaccination trial. There was a positive humeral response through the significant marked elevation of antibody titers against different pasteurella species reaching its peak (1:64-1:256) around the 3th month post vaccination in comparison with the control. An evident passive mouse protection against the challenge of virulent strains of P. multocida type A, B and D and Mannheimia haemolytica types A & T were also recorded. Biochemically, there were no significant differences in the biochemical profiles, lipid peroxidation and Matrix MetaloProteinase (MMP) enzymes activity between the vaccinated and control group. Camel vaccination with a polyvalent pasteurella vaccine every 6th months is recommended to ensure complete and restricted control measures against pasteurellosis in Egypt.

Key words: camel, pasteurellosis, vaccine, humeral and biochemical