E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain

Aymen Mabrouk, Amina Sakly, Feiza Mnasria, Lobna Ezzi.

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  • Abstract
    Lead (Pb) is a pervasive industrial and environmental pollutant that seriously impairs the central nervous system, primarily by disrupting the redox balance. The current research was conducted to explore the possible beneficial action of thymoquinone (TQ), the main active component in Nigella sativa seed volatile oil, against brain oxidative stress and DNA damage caused by Pb. Wistar adult male rats were treated with TQ (5 mg/kg/day, per os) and/or Pb (2000 ppm of Pb acetate in drinking water) for five weeks. Results showed that Pb exposure significantly increased metal content, malondialdehyde concentration and DNA damage (assessed by comet assay), but significantly decreased the level of reduced glutathione and the activities of catalase, glutathione peroxidase, and superoxide dismutase in the brain tissue. These detrimental effects Pb-induced, except tissue metal accumulation, were significantly improved by TQ supplementation. In conclusion, our findings suggested that TQ might be a promising therapeutic alternative in Pb neurotoxicity.

    Key words: Thymoquinone, lead, genotoxicity, oxidative stress, brain, rat.


     
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    How to Cite this Article
    Pubmed Style

    Mabrouk A, Sakly A, Mnasria F, Ezzi L. Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. AJVS. 2021; 69(2): 113-118. doi:10.5455/ajvs.51335


    Web Style

    Mabrouk A, Sakly A, Mnasria F, Ezzi L. Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. http://www.alexjvs.com/?mno=51335 [Access: August 17, 2021]. doi:10.5455/ajvs.51335


    AMA (American Medical Association) Style

    Mabrouk A, Sakly A, Mnasria F, Ezzi L. Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. AJVS. 2021; 69(2): 113-118. doi:10.5455/ajvs.51335



    Vancouver/ICMJE Style

    Mabrouk A, Sakly A, Mnasria F, Ezzi L. Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. AJVS. (2021), [cited August 17, 2021]; 69(2): 113-118. doi:10.5455/ajvs.51335



    Harvard Style

    Mabrouk, A., Sakly, . A., Mnasria, . F. & Ezzi, . L. (2021) Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. AJVS, 69 (2), 113-118. doi:10.5455/ajvs.51335



    Turabian Style

    Mabrouk, Aymen, Amina Sakly, Feiza Mnasria, and Lobna Ezzi. 2021. Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. Alexandria Journal of Veterinary Sciences, 69 (2), 113-118. doi:10.5455/ajvs.51335



    Chicago Style

    Mabrouk, Aymen, Amina Sakly, Feiza Mnasria, and Lobna Ezzi. "Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain." Alexandria Journal of Veterinary Sciences 69 (2021), 113-118. doi:10.5455/ajvs.51335



    MLA (The Modern Language Association) Style

    Mabrouk, Aymen, Amina Sakly, Feiza Mnasria, and Lobna Ezzi. "Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain." Alexandria Journal of Veterinary Sciences 69.2 (2021), 113-118. Print. doi:10.5455/ajvs.51335



    APA (American Psychological Association) Style

    Mabrouk, A., Sakly, . A., Mnasria, . F. & Ezzi, . L. (2021) Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. Alexandria Journal of Veterinary Sciences, 69 (2), 113-118. doi:10.5455/ajvs.51335





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