E-ISSN 2536-9520 | ISSN 1110-2047
 
2026, Vol: 89
89Current Volume Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Original Article
Online Published: 17 May 2021
 


Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain

Aymen Mabrouk, Amina Sakly, Feiza Mnasria, Lobna Ezzi.

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    • Abstract
    Lead (Pb) is a pervasive industrial and environmental pollutant that seriously impairs the central nervous system, primarily by disrupting the redox balance. The current research was conducted to explore the possible beneficial action of thymoquinone (TQ), the main active component in Nigella sativa seed volatile oil, against brain oxidative stress and DNA damage caused by Pb. Wistar adult male rats were treated with TQ (5 mg/kg/day, per os) and/or Pb (2000 ppm of Pb acetate in drinking water) for five weeks. Results showed that Pb exposure significantly increased metal content, malondialdehyde concentration and DNA damage (assessed by comet assay), but significantly decreased the level of reduced glutathione and the activities of catalase, glutathione peroxidase, and superoxide dismutase in the brain tissue. These detrimental effects Pb-induced, except tissue metal accumulation, were significantly improved by TQ supplementation. In conclusion, our findings suggested that TQ might be a promising therapeutic alternative in Pb neurotoxicity.

    Key words: Thymoquinone, lead, genotoxicity, oxidative stress, brain, rat.


    		 
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    How to Cite this Article
    Pubmed Style

    Mabrouk A, Sakly A, Mnasria F, Ezzi L. Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. AJVS. 2021; 69(2): 113-119. doi:10.5455/ajvs.51335

    Web Style

    Mabrouk A, Sakly A, Mnasria F, Ezzi L. Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. https://www.alexjvs.com/?mno=51335 [Access: June 28, 2026]. doi:10.5455/ajvs.51335

    AMA (American Medical Association) Style

    Mabrouk A, Sakly A, Mnasria F, Ezzi L. Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. AJVS. 2021; 69(2): 113-119. doi:10.5455/ajvs.51335


    Vancouver/ICMJE Style

    Mabrouk A, Sakly A, Mnasria F, Ezzi L. Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. AJVS. (2021), [cited June 28, 2026]; 69(2): 113-119. doi:10.5455/ajvs.51335


    Harvard Style

    Mabrouk, A., Sakly, . A., Mnasria, . F. & Ezzi, . L. (2021) Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. AJVS, 69 (2), 113-119. doi:10.5455/ajvs.51335


    Turabian Style

    Mabrouk, Aymen, Amina Sakly, Feiza Mnasria, and Lobna Ezzi. 2021. Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. Alexandria Journal of Veterinary Sciences, 69 (2), 113-119. doi:10.5455/ajvs.51335


    Chicago Style

    Mabrouk, Aymen, Amina Sakly, Feiza Mnasria, and Lobna Ezzi. "Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain." Alexandria Journal of Veterinary Sciences 69 (2021), 113-119. doi:10.5455/ajvs.51335


    MLA (The Modern Language Association) Style

    Mabrouk, Aymen, Amina Sakly, Feiza Mnasria, and Lobna Ezzi. "Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain." Alexandria Journal of Veterinary Sciences 69.2 (2021), 113-119. Print. doi:10.5455/ajvs.51335


    APA (American Psychological Association) Style

    Mabrouk, A., Sakly, . A., Mnasria, . F. & Ezzi, . L. (2021) Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. Alexandria Journal of Veterinary Sciences, 69 (2), 113-119. doi:10.5455/ajvs.51335




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    About Alexandria Journal of Veterinary Sciences

    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110-204 ... Read more.



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    Egypt.

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