E-ISSN 2536-9520 | ISSN 1110-2047
 
2024, Vol: 83
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Original Article 


Pathological Evaluation of Nigella Sativa Oil and Resveratrol Against Fipronil Induced Toxicity In Male Albino Rats

Mona A. Mohamed, El-Sayed E. Mehanna, Samah S. Oda, Hossam G. Tohamy, Asmaa F. Khafaga.


Abstract
Fipronil (FPN) is a broad-spectrum insecticide widely used in agriculture and veterinary applications. FPN repressed the cellular enzymatic and non-enzymatic antioxidants, resulted in oxidative injuries. Both nigella sativa oil (NSO) and resveratrol (RSV) had antioxidant activities. The present study aimed to assess the ameliorative effect of NSO and RSV against FPN induced toxicosis in male albino rats. Rats were divided into six groups. The first group was administered FPN (10 mg/kg); the second received FPN (10 mg/kg) and NSO (1ml/kg); the third group received FPN (10mg/kg) and RSV (20mg/kg); fourth, and fifth were treated with NSO (1ml/kg) and RSV (20mg/kg), respectively. The sixth group was the control. The results showed that FPN significantly increased serum levels of urea, creatinine, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. FPN-intoxicated rats revealed a significant increase in the level of MDA and significant decrease in GSH level in liver and brain tissues. While, kidney tissue revealed a significant decrease in renal GSH concentration and non-significant increase in renal MDA. Furthermore, FPN showed histological changes in liver, kidney, brain and heart tissues. In contrast, administration of NSO and RSV ameliorated the FPN-induced oxidative damage, and histopathological alterations possibly due to their antioxidant properties.

Key words: Fipronil, nigella sativa, resveratrol, histopathology


 
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How to Cite this Article
Pubmed Style

Mohamed MA, Mehanna EE, Oda SS, Tohamy HG, Khafaga AF. Pathological Evaluation of Nigella Sativa Oil and Resveratrol Against Fipronil Induced Toxicity In Male Albino Rats. AJVS. 2021; 70(1): 126-134. doi:10.5455/ajvs.63161

Web Style

Mohamed MA, Mehanna EE, Oda SS, Tohamy HG, Khafaga AF. Pathological Evaluation of Nigella Sativa Oil and Resveratrol Against Fipronil Induced Toxicity In Male Albino Rats. https://www.alexjvs.com/?mno=63161 [Access: September 13, 2024]. doi:10.5455/ajvs.63161

AMA (American Medical Association) Style

Mohamed MA, Mehanna EE, Oda SS, Tohamy HG, Khafaga AF. Pathological Evaluation of Nigella Sativa Oil and Resveratrol Against Fipronil Induced Toxicity In Male Albino Rats. AJVS. 2021; 70(1): 126-134. doi:10.5455/ajvs.63161


Vancouver/ICMJE Style

Mohamed MA, Mehanna EE, Oda SS, Tohamy HG, Khafaga AF. Pathological Evaluation of Nigella Sativa Oil and Resveratrol Against Fipronil Induced Toxicity In Male Albino Rats. AJVS. (2021), [cited September 13, 2024]; 70(1): 126-134. doi:10.5455/ajvs.63161


Harvard Style

Mohamed, M. A., Mehanna, . E. E., Oda, . S. S., Tohamy, . H. G. & Khafaga, . A. F. (2021) Pathological Evaluation of Nigella Sativa Oil and Resveratrol Against Fipronil Induced Toxicity In Male Albino Rats. AJVS, 70 (1), 126-134. doi:10.5455/ajvs.63161


Turabian Style

Mohamed, Mona A., El-Sayed E. Mehanna, Samah S. Oda, Hossam G. Tohamy, and Asmaa F. Khafaga. 2021. Pathological Evaluation of Nigella Sativa Oil and Resveratrol Against Fipronil Induced Toxicity In Male Albino Rats. Alexandria Journal of Veterinary Sciences, 70 (1), 126-134. doi:10.5455/ajvs.63161


Chicago Style

Mohamed, Mona A., El-Sayed E. Mehanna, Samah S. Oda, Hossam G. Tohamy, and Asmaa F. Khafaga. "Pathological Evaluation of Nigella Sativa Oil and Resveratrol Against Fipronil Induced Toxicity In Male Albino Rats." Alexandria Journal of Veterinary Sciences 70 (2021), 126-134. doi:10.5455/ajvs.63161


MLA (The Modern Language Association) Style

Mohamed, Mona A., El-Sayed E. Mehanna, Samah S. Oda, Hossam G. Tohamy, and Asmaa F. Khafaga. "Pathological Evaluation of Nigella Sativa Oil and Resveratrol Against Fipronil Induced Toxicity In Male Albino Rats." Alexandria Journal of Veterinary Sciences 70.1 (2021), 126-134. Print. doi:10.5455/ajvs.63161


APA (American Psychological Association) Style

Mohamed, M. A., Mehanna, . E. E., Oda, . S. S., Tohamy, . H. G. & Khafaga, . A. F. (2021) Pathological Evaluation of Nigella Sativa Oil and Resveratrol Against Fipronil Induced Toxicity In Male Albino Rats. Alexandria Journal of Veterinary Sciences, 70 (1), 126-134. doi:10.5455/ajvs.63161




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    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



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